Patents Represented by Attorney, Agent or Law Firm Peter Butch
  • Patent number: 6376472
    Abstract: A compound of the formula wherein K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methylallyl, 2-butenyl, or cycloalkyl where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen, alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, or substituted heterocyclylalkyl; and n and p are independently 0, 1, 2, or 3, provided that n+p is at least 1; T is hydrogen, alkyl, alkylcarbonyl, alkylthiocarbonyl, halo, carboxyl, A and B are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR′; or a pharmaceutically acceptable salt thereof, a pharmaceutic-ally acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: April 23, 2002
    Assignee: Aventis Pharmaceuticals, Inc.
    Inventors: Michael R. Myers, Martin P. Maguire, Alfred P. Spada, William R. Ewing, Henry W. Pauls, Yong Mi Choi-Sledeski
  • Patent number: 6245760
    Abstract: This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: June 12, 2001
    Assignee: Aventis Pharmaceuticals Products, Inc
    Inventors: Wei He, Michael R. Myers, Alfred P. Spada
  • Patent number: 6159978
    Abstract: This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: December 12, 2000
    Assignee: Aventis Pharmaceuticals Product, Inc.
    Inventors: Michael R. Myers, Alfred P. Spada, Paul E. Persons, Martin P. Maguire
  • Patent number: 6140504
    Abstract: Compounds of the formula: ##STR1##
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: October 31, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Scott I. Klein, Kevin R. Guertin, Alfred P. Spada
  • Patent number: 6127515
    Abstract: This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR.sup.1 ; and R.sup.1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: October 3, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Franco Manfre, Benoit J. Vanasse, Richard F. Labaudiniere, George C. Morton
  • Patent number: 5284674
    Abstract: Powdered dairy creamer compositions are disclosed, formed by drying an emulsion containing from about 5% to about 45% by weight of an edible fat component, including one or more edible fats, from about 5% to about 75% by weight of nonfat dry milk solids, from about 0.1% to about 1.0% by weight of a hydrophilic emulsifier and from about 0.05% to about 0.5% by weight of a lipophilic emulsifier, wherein the hydrophilic emulsifier and the lipophilic emulsifier are present in a ratio of about 2:1, and one or more emulsion stabilizers present in an amount effective to stabilize the emulsion without the presence of the stabilizer being perceptible with respect to the organoleptic properties of the composition. Methods of forming the powdered dairy creamer compositions are also disclosed.
    Type: Grant
    Filed: May 11, 1992
    Date of Patent: February 8, 1994
    Inventor: Susan C. Fazio