Abstract: A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-&agr;-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5′-sulfonated ring-closed intermediate also allows for synthesis of 5′-amino- and thio-LNAs.

Abstract: The present invention relates to a polyethoxylated retinamide derivative represented by formula (I), which is useful as an agent for inhibiting skin aging; in R represents hydrogen or C1-6 lower alkyl and n denotes the number of 2 to 100, and the process for preparing the compound of formula (I) as an effective component.

Abstract: A fragrant ink is provided. The fragrant ink comprises an alcohol component, an imaging component, a fragrant agent component, and a deionized water component. In certain embodiments, the fragrant ink further comprises an ethanol component. The imaging component includes at least one of a soluble dye or pigment materials. The fragrant agent preferably includes a phenolic compound. The fragrant ink causes the paper on which it is printed to emit a pleasant scent.

Abstract: A foam break device and a system for use of the device. The system comprises an outlet tube for a filling machine using an air gap proportioner. The device has a plurality of vanes and beveled edges for positioning in the bottom of the outlet tube of the filling machine. The device reduces the amount of foam discharged from the system.