Patents Represented by Attorney, Agent or Law Firm Peter G. Carroll
  • Methods for treatment of enzyme preparations
    Patent number: 5532145
    Abstract: Method useful for solving the problem of contamination of protein with nucleic acid. Rendering amplifiable contaminating nucleic acid in enzyme preparations substantially unamplifiable prior to use of the enzyme.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: July 2, 1996
    Assignee: Steritech, Inc.
    Inventors: John W. Tessman, George D. Cimino, Stephen T. Isaacs, John E. Hearst
  • Synthetic media compositions and methods for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
    Patent number: 5482828
    Abstract: Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Compositions of synthetic media are described which optimize conditions for inactivation of contaminants in blood cell preparations, using 8-methoxypsoralen, prior to long term storage and transfusion.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: January 9, 1996
    Assignee: Steritech, Inc.
    Inventors: Lily Lin, Lawrence Corash, Stephen Isaacs, George Cimino
  • Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
    Patent number: 5459030
    Abstract: Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets using 8-methoxypsoralen.
    Type: Grant
    Filed: June 2, 1993
    Date of Patent: October 17, 1995
    Assignee: Steritech, Inc.
    Inventors: Lily Lin, Laurence Corash
  • Compounds for the photodecontamination of pathogens in blood
    Patent number: 5399719
    Abstract: Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: March 21, 1995
    Assignee: Steritech, Inc.
    Inventors: Susan Wollowitz, Stephen T. Isaacs, Henry Rapoport, Hans P. Spielmann
  • Methods for measuring the inactivation of pathogens
    Patent number: 5372929
    Abstract: Methods for measuring pathogen inactivation, and in particular, methods for measuring pathogen inactivation in blood and blood products after photochemical decontamination. The methods involve measuring the inhibition of template-dependent enzymatic synthesis of nucleic acid following the addition of compounds that add covalently to nucleic acid.
    Type: Grant
    Filed: January 27, 1992
    Date of Patent: December 13, 1994
    Inventors: George D. Cimino, Lily Lin
  • Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen
    Patent number: 5288605
    Abstract: Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated using 8-methoxypsoralen prior to long term storage and transfusion.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: February 22, 1994
    Assignee: Steritech, Inc.
    Inventors: Lily Lin, Lawrence Corash, Stephen T. Isaacs, Carl V. Hanson, George D. Cimino