Abstract: A medical instrument driving member and end effector connection of the type having on the distal end of the instrument drive wire a hemispherical or knob-like terminus (38) which is seated so as to rotate freely in the countersunk bore (22) of the end effector tang (20), considerably reducing operating friction and permitting smooth and reliable opening and closing of the instrument end effectors (18), and rendering the entire device of a simpler construction and reliable in operation, while concurrently making it considerably less expensive to produce.