Patents Represented by Attorney, Agent or Law Firm Peter J. Dehlinger
  • Patent number: 7024408
    Abstract: Disclosed are a computer-readable code, system and method for classifying a target document in the form of a digitally encoded natural-language text as belonging to one or more of two or more different classes. For each of a plurality of non-generic words and/or words groups characterizing the target document, there is determined a selectivity value calculated as the frequency of occurrence of that term in a library of texts in one field, relative to the frequency of occurrence of the same term in one or more other libraries of texts in one or more other fields, respectively, and the document is represented as a vector of terms, where the coefficient assigned to each term is a function of the selectivity value determined for that term. There is then determined, for each of the plurality of sample texts having associated classification identifiers, a match score related to the number of descriptive terms present in or derived from that text that match those in the target text.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: April 4, 2006
    Assignee: Word Data Corp.
    Inventors: Peter J. Dehlinger, Shao Chin
  • Patent number: 6828105
    Abstract: The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: December 7, 2004
    Assignee: AVI BioPharma, Inc.
    Inventors: David A. Stein, Douglas E. Skilling, Patrick L. Iversen, Alvin W. Smith
  • Patent number: 6821778
    Abstract: This invention relates to methods of using human dendritic cells to present antigens for the induction of antigen-specific T cell-mediated immune responses. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to antigens, co-culturing the antigen-pulsed dendritic cells with &ggr;&dgr;-T cell receptor-positive-T cells (&ggr;&dgr;-TCR+ T cells) obtained from unprimed or weakly primed individuals for the stimulation of antigen-specific T cell proliferative and cytotoxic activities. The dendritic cell antigen presentation system described herein has a wide range of applications, including but not limited to, activation and expansion of large numbers of antigen-specific major histocompatibility complex-unrestricted T cells for use in adoptive cellular immunotherapy against infectious diseases and cancer.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: November 23, 2004
    Assignee: The Board of Trustees of Leland Stanford Junior University
    Inventors: Edgar G. Engleman, Anita Mehta, Masaru Takamizawa, Francesco Fagnoni, Sergiusz Markowicz
  • Patent number: 6818113
    Abstract: A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having upstream and downstream channel portions and first, second, and third side channels that intersect the electrolyte channel between the two channel portions at first, second, and third ports, respectively. In the method, a sample is moved electrokinetically into the electrolyte channel, to form a defined sample volume therein. By simultaneously controlling the voltage applied to the three side channels, and at least one of the upstream and downstream channel end portions, the sample volume element can be shaped to have a desired leading- and trailing-edge shape and/or distribution of sample components within the volume elements.
    Type: Grant
    Filed: February 10, 2001
    Date of Patent: November 16, 2004
    Assignee: Aclara Biosciences, Inc.
    Inventors: Stephen J. Williams, Hong Dong Tan, Hung Pin Kao, Wyatt N. Vreeland
  • Patent number: 6770070
    Abstract: A method and apparatus for obtaining a lung biopsy with an apparatus capable of sealing tears within the lung and pleural space to reduce the risk of pneumothorax or pulmonary hemorrhage. The apparatus includes an RF ablation apparatus having a lung biopsy device an energy delivery device including at least one electrode designed to be deployed into target lung tissue, and a sensor. A closure device is operatively coupled to the elongated member to produce an immediate tight seal and promote healing at the tissue interface. A feedback control device is operatively coupled to the sensor and a RF source for controlling energy delivered to the electrodes.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: August 3, 2004
    Assignee: R. ITA Medical Systems, Inc.
    Inventor: Daniel J. Balbierz
  • Patent number: 6759202
    Abstract: Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In one embodiment of the invention, a plurality of different-sequence probe pairs are added to a target polynucleotide, where each probe pair includes two polynucleotide probe elements which are complementary in sequence to adjacent portions of a selected one of the target sequences in the target polynucleotide. In each probe pair, one of the probe elements contains a non-polynucleotide polymer chain which imparts a distinctive mobility to the associated probe pair, when the elements in the pair are ligated. The other element in the pair contains a detectable reporter label. After the probe pairs have been allowed to hybridize with the target polynucleotide, the hybridized polynucleotides are treated under conditions effective to ligate the end subunits of target-bound probe elements when their end subunits are base-paired with adjacent target bases.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: July 6, 2004
    Assignee: Applera Corporation
    Inventors: Paul David Grossman, Steven Fung, Steven Michael Menchen, Sam Lee Woo, Emily Susan Winn-Deen
  • Patent number: 6756204
    Abstract: Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify those probes which are bound to the target polynucleotide in a base-specific manner. The resulting labeled probes include a polymer chain which imparts to each different-sequence probe, a distinctive ratio of charge/translational frictional drag, and a detectable label. The labeled probes are fractionated by electrophoresis in a non-sieving matrix, and the presence of one or more selected sequences in the target polynucleotide are detected according to the observed electrophoretic migration rates of the labeled probes in a non-sieving medium.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: June 29, 2004
    Assignee: Applera Corporation
    Inventors: Paul David Grossman, Steven Fung, Steven Michael Menchen, Sam Lee Woo, Emily Susan Winn-Deen
  • Patent number: 6730202
    Abstract: In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CRE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electrolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. The supply and drain channels each are inclined to the electrolyte channel. Means are provided for electrokinetically injecting the sample into the sample volume.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: May 4, 2004
    Assignee: Zeptosens AG
    Inventors: Andreas Manz, D. Jed Harrison, Carlo S. Effenhauser
  • Patent number: 6730206
    Abstract: An improved microfluidics device and system for sample loading and injection are disclosed. The device includes three main channels—a separation channel, supply channel, and drain channel—for use in loading and injecting a sample from the supply channel. Pairs of peripheral channels connecting the supply channel with upstream and downstream regions of the separation channel, and connecting supply and drain channels to a downstream region of the separation channel promote fluid flow and/or ion in the channel network to effect (i) sample shaping in the separation channel, when an electrokinetic or pneumatic force is applied between the supply and drain channels, and (ii) sample pullback in the supply and drain channels, when an electrokinetic or pneumatic force is applied between opposite ends of the separation channel. The system incorporates the device, electrodes that interact with reservoirs in the device, and a control unit.
    Type: Grant
    Filed: March 17, 2001
    Date of Patent: May 4, 2004
    Assignee: Aclara Biosciences, Inc.
    Inventors: Antonio J. Ricco, Travis D. Boone
  • Patent number: 6716593
    Abstract: Disclosed is a method for measuring a level of pyridinoline and/or deoxypyridinoline in a sample. In the method, a non-hydrolyzed sample containing one or more peptide-bound collagen pyridinium crosslinks selected from the group consisting of pyridinoline, deoxypyridinoline, or both, is contacted with a protease reagent under conditions effective for the protease reagent to cleave the crosslinks from attached collagen amino acids and peptides, so that peptide-bound forms are converted to native, peptide-free pyridinoline and deoxypyridinoline. After proteolysis, the level(s) of native, peptide-free pyridinoline and/or deoxypyridinoline are measured. Preferably, proteolysis is effective to ensure that at least 80% of total pyridinium crosslinks are present as the native, peptide-free forms. The method is particularly useful in screening or monitoring collagen degradation activity. Kits and reagents for use in the method are also disclosed.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: April 6, 2004
    Assignee: Quidel Corporation
    Inventors: Simon P. Robins, Jeffrey D. Brady
  • Patent number: 6706164
    Abstract: In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electrolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. The supply and drain channels each are inclined to the electrolyte channel. Means are provided for electrokinetically injecting the sample into the sample volume.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: March 16, 2004
    Assignee: Zeptosens AG
    Inventors: Andreas Manz, D. Jed Harrison, Carlo S. Effenhauser
  • Patent number: 6699377
    Abstract: In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. The supply and drain channels each are inclined to the electrolyte channel. Means are provided for electrokinetically injecting the sample into the sample volume.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: March 2, 2004
    Assignee: Zeptosens AG
    Inventors: Andreas Manz, D. Jed Harrison, Carlo S. Effenhauser
  • Patent number: 6699378
    Abstract: In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electrolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. The supply and drain channels each are inclined to the electrolyte channel. Means are provided for electrokinetically injecting the sample into the sample volume.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: March 2, 2004
    Assignee: Zeptosens AG
    Inventors: Andreas Manz, D. Jed Harrison, Carlo S. Effenhauser
  • Patent number: 6689127
    Abstract: An ablation apparatus includes an ablation energy source producing an electromagnetic energy output. A monopolar multiple antenna device is included and has a primary antenna with a longitudinal axis, a central lumen and a distal end, and a secondary antenna with a distal end. The secondary antenna is deployed from the primary antenna central lumen in a lateral direction relative to the longitudinal axis. The primary antenna and secondary antennas are each electromagnetically coupled to the electromagnetic energy source.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: February 10, 2004
    Assignee: Rita Medical Systems
    Inventors: Edward J. Gough, Alan A. Stein
  • Patent number: 6663624
    Abstract: An RF treatment apparatus includes a catheter with a catheter lumen. A removable needle electrode is positioned in the catheter lumen in a fixed relationship to the catheter. The needle electrode includes a needle lumen and a needle electrode distal end. A removable introducer is slidably positioned in the needle lumen. The introducer includes an introducer distal end. A first sensor is positioned on a surface of the needle electrode or the insulator. An RF power source is coupled to the needle electrode and a return electrode. An insulator sleeve is slidably positioned around the electrode and includes a second sensor. Resources are associated with the electrodes, sensors as well as the RF power source for maintaining a selected power at the electrode independent of changes in current or voltage.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: December 16, 2003
    Assignee: Rita Medical Systems, Inc.
    Inventors: Stuart D. Edwards, James Baker, Bruno Strul, Ronald G. Lax
  • Patent number: 6660002
    Abstract: An RF treatment apparatus includes a catheter with a catheter lumen. A removable needle electrode is positioned in the catheter lumen in a fixed relationship to the catheter. The needle electrode includes a needle lumen and a needle electrode distal end. A removable introducer is slidably positioned in the needle lumen. The introducer includes an introducer distal end. A first sensor is positioned on a surface of the needle electrode or the insulator. An RF power source is coupled to the needle electrode and a return electrode. An insulator sleeve is slidably positioned around the electrode and includes a second sensor. Resources are associated with the electrodes, sensors as well as the RF power source for maintaining a selected power at the electrode independent of changes in current or voltage.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: December 9, 2003
    Assignee: Rita Medical Systems, Inc.
    Inventors: Stuart D. Edwards, James Baker, Bruno Strul, Ronald G. Lax
  • Patent number: 6660846
    Abstract: Disclosed are invertebrate and vertebrate synaptic vesicle amino acid transporter compositions which define a novel family of transporter proteins, recombinant vectors and cells comprising nucleic acid sequences encoding vertebrate synaptic vesicle amino acid transporter proteins and antibodies directed against such proteins. Also disclosed are methods for utilizing such compositions in screening assays and treatment regimens.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: December 9, 2003
    Assignees: The Regents of the University of CA, University of Utah Research Foundation
    Inventors: Robert H. Edwards, Richard J. Reimer, Steven L. McIntire, Erik M. Jorgensen, Kim Schuske
  • Patent number: 6652516
    Abstract: A cell necrosis apparatus has a flexible introducer including a lumen and a distal end sufficiently sharp to penetrate tissue. An energy delivery device is positionable in the introducer as the introducer is advanced through tissue. The energy delivery device includes a first RF electrode with a tissue piercing distal portion and a second RF electrode with a tissue piercing distal portion. The first and second RF electrodes are deployable with curvature from the introducer at a selected tissue site in a lateral direction away from the periphery of the introducer.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: November 25, 2003
    Assignee: Rita Medical Systems, Inc.
    Inventor: Edward J. Gough
  • Patent number: 6653077
    Abstract: Method and materials are provided for screening for genetic polymorphism in a test population of DNA fragments. Heteroduplexes are formed between members of a test DNA population and their corresponding complements from a reference DNA population. Perfectly matched heteroduplexes are destroyed or separated from those containing mismatched sequences. Preferably, perfectly matched heteroduplexes are digested by a single stranded exonuclease which requires double stranded DNA as a substrate, such as E. coli exonuclease III. Amplicons are formed from mismatched heteroduplexes, preferably by extending the partially digested duplexes after treatment with exonuclease III followed by PCR amplification. The resulting amplicons are inserted into a cloning vector which is used to transform a bacterial host. After host cells are plated and allowed to form colonies, clones are picked and sequenced to identify DNA fragments containing polymorphic sequences.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: November 25, 2003
    Assignee: Lynx Therapeutics, Inc.
    Inventor: Sydney Brenner
  • Patent number: 6649071
    Abstract: A treatment effective for removing or substantially reducing the amount of Cr+6 present in drinking water or wastewater is described. The method includes adding a stannous salt of a non-carbon acid, in an amount effective to reduce most or substantially all of the chromic ion in the water.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: November 18, 2003
    Assignee: A. S. Incorporated
    Inventor: William E. Stapp