Abstract: A method of making a pressure sensitive matrix patch for transdermal delivery of a drug is disclosed. The method includes the steps of dissolving a hydrophilic salt form of the drug in the water phase of an aqueous dispersion of a hydrophobic pressure sensitive adhesive, casting the resulting mixture as a thin film, and evaporating the water. The physical stability of the drug in the film is excellent, and crystallization of the drug is inhibited. A method of increasing the transdermal flux of an acidic drug is also disclosed.

Abstract: A method of tying neckties is presented whereby users can avoid the common frustration of repeated tying to achieve the desired lengths of the two ends of the tie to ultimately position the tie at a desired distance from neck down. The method includes tying the tie initially to the wearer's satisfaction, then marking the desired lengths, first on the wide end by removing the wide end from the knot while holding the narrow end in place against the wearer's neck, and then on the narrow end after retying by reinserting the wide end through the knot. A preferred embodiment of the invention includes markers made of commercially available flexible double-sided adhesive to hold the two ends of the tie together thereby providing the additional benefit of preventing flapping.