Abstract: The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1—R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.
Type:
Grant
Filed:
July 13, 2006
Date of Patent:
June 30, 2009
Assignee:
Pfizer, Inc.
Inventors:
Yves A. Chantigny, Edward F. Kleinman, Ralph P. Robinson
Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
Abstract: A motion transmitting device having an input shaft and a concentric output shaft assembly, and an eccentrically rotated gear driven by the input shaft to provide an eccentric output. The gear has teeth which engage and subsequently disengage with independently movable meshing elements, such as pins. A pair of datum members have round holes to individually guide and limit movement of the meshing elements within predetermined limits of orbital motion relative to the datum members. The eccentric output drive of the gear is converted to rotary motion of the output shaft assembly. The input shaft and the output shaft assembly are rotatable about a common axis.
Type:
Grant
Filed:
July 16, 1984
Date of Patent:
February 4, 1986
Assignee:
Emerson Electric Company
Inventors:
Roger P. Butterfield, Charles M. Allaben, Jr.