Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.

Abstract: The device comprises filtration means and pumping means each housed in a compact unit mounted with the panels of a swimming pool basin. The unit includes a compartment (A) housing the filtration means in communication with the water of the basin, and a compartment (B) out of the water which contains the pumping means. The unit includes in the filtration compartment an assembly having first and second 90° elbows for intaking water from the basin. One of the elbows has arrangements for coupling to the bottom of the member containing the filtration means, while the other elbow has arrangements for coupling with a straight element. The unit also includes in the pumping compartment third and fourth 90° elbows for the intake of water. One of the third and fourth elbows is coupled to a straight element, and the other elbow of the third and fourth elbows is connected to a delivery side of the pumping means. Also included in the pumping compartment are fourth and fifth elbows for delivering water to the basin.

Abstract: This invention relates to a process for manufacturing a ski, or like board for gliding over snow, which comprises, on the surface, embedded elements constituted by elements of additional protecting and decorative layers, these elements being flush with the surface of the ski. According to the invention, the protecting and decorative sheet is laid flat, before being placed in the mould, and the thin elements to be embedded are added thereon by bonding. The assembly of the ski elements is then moulded conventionally, with the result that the inner, uniformly smooth surface of the lid of the mould presses on the additional elements and consequently embeds them in the protecting and decorative sheet.

Abstract: A mechanism for the treatment of materials by pressurized water jets includes a body (1) for supplying water under pressure which includes a feeding chamber (2) extending over the whole length of the body, and wherein water under pressure is fed to the feeding chamber through a filter (4). The body also includes a distributing zone for distributing water under pressure over a whole treatment length against a plate (7) provided with micro-perforations which define water needles (8) directed against the surface (S) of the material to be treated. The material is supported by a carriage element subjected to a suction source eliminating the treatment water.

Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.

Abstract: A process for sputter deposition wherein high aspect ratio apertures are coated with conductive films exhibiting low bulk resistivity, low impurity concentrations, and regular morphologies. A collimator is used having an aspect ratio that approximates the aspect ratio of the apertures.

Abstract: An apparatus for imparting a controlled relative displacement of two parallel surfaces along a single axis or along two orthogonal axes is disclosed. Controlled displacement along any axes, orthogonal or otherwise, may be obtained by stacking appropriately oriented single-axis units. The apparatus uses a force-generating means and connecting beams acting in concert to produce a relative displacement of two rigid parallel frames. An imaging means is mounted on one rigid frame and a photosensitive matrix on the other to provide an electro-optical detector system in which the image field may be periodically displaced along a closed trajectory to cover the interstices between the detector elements of the photosensitive matrix. A method for the use of the apparatus to generate electronic picture information is also disclosed.

Abstract: Novel 2,5-benzodiazocines of formulas II and IV, pharmaceutical compositions containing them, processes for preparing them and methods of treating cardiac arrhythmias in mammals utilizing them.

Abstract: 6-Alkyl-5-(6, or 7-quinolinyl)-3-(substituted)-2(1H)-pyridinones useful as cardiotonics are synthesized by reaction of trialkylquinolinylstannanes with 6-alky-5-halo-3-(substituted)-2(1H)-pyridinones. Compositions containing these pyridinones and methods of using them to treat congestive heart failure are provided.

Abstract: Conjugates of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with p-aminophenylsaccharides, with aminoalkyl-derivatized dextrans and with polylysines and polyornithines are prepared by condensation using diimides. Methods and compositions for the use of such conjugates to protect mammals from reperfusion injury are also disclosed.

Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

Abstract: The combination of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with a superoxide dismutase optionally containing a catalase and ascorbic acid provides enhanced protection from oxidant injury.Administration of 6-hydroxy-2,5,7,8-tetramethyl chroman-2-carboxylic acid, SOD, and optionally CAT and/or ascorbic acid prior to or simultaneously with resuming normal blood supply to mammalian tissue following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion. Administration of Vitamin E, SOD, and CAT similarly provide protection from oxidant injury.

Abstract: A process for spray-coating tablets and the like utilizing only an acrylate enteric polymer and plasticizer in water is disclosed. The process can be practiced on a commercial scale and requires no antiadherent in the coating formulation. The process comprises providing inlet air having a dew point below about 10.degree. C. and a temperature between 35.degree. and 60.degree. C.

Abstract: 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4-or 3-pyridinyl, or N-oxides thereof, or phenyl or substituted phenyl.

Abstract: N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

Abstract: An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.

Abstract: Novel 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4- or 3-pyridinyl, or phenyl or substituted phenyl.

Abstract: N-[(alkylamino)alkyl]-4,5-diaryl-1H-imidazole-1-acetamides useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of a diaryl imidazole-1-acetic acid with an appropriate diamine.

Abstract: N-[(alkylamino)alkyl]-4,5-diaryl-1H-pyrazole-1-acetamides, wherein at least one of the aryl substituents is a pyridine, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.

Abstract: N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.