Patents Represented by Attorney Philippe L. Derette

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  • Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
    Patent number: 7754745
    Abstract: Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: July 13, 2010
    Assignee: Merck Frosst Canada Ltd.
    Inventors: Chun Sing Li, Yeeman K. Ramtohul