Patents Represented by Attorney Phillipe L. Durette

Find this attorney in the Justia Lawyer Directory

  • 11-?-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
    Patent number: 7329683
    Abstract: Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof: are selective inhibitors of the 11?-HSD1 enzyme. They inhibit the 11?-HSD1-mediated conversion of cortisone and other 11-keto-glucocorticoids to cortisol and other 11?-hydroxy-glucocorticoids. The 11?-HSD1 inhibitors therefore decrease the amount of cortisol in target tissues, thereby modulating the effects of cortisol.
    Type: Grant
    Filed: January 28, 2003
    Date of Patent: February 12, 2008
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Rolf Thieringer, Steven S. Mundt, Anne Hermanowski-Vosatka, Donald W. Graham, Gool F. Patel, Susan D. Aster, Sherman T. Waddell, Steven H. Olson, Milana Maletic