Patents Represented by Attorney Pierce Atwood LLP
  • Patent number: 8349559
    Abstract: The present invention relates to the generation of a population of Epo-responsive marrow derived cells that express Epo-responsive genes and gene products. The present invention also relates to the detection of Epo-responsive genes and gene products as well as to the detection of the administration of Epo, Epo-derivatives and Epo-mimetics in subjects.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: January 8, 2013
    Assignee: Maine Medical Center
    Inventor: Don Wojchowski
  • Patent number: 8348853
    Abstract: A system and method for aiding in the diagnosis of a respiratory dysfunction is described. More particularly, a system and method for aiding in the diagnosis of one or more pulmonary embolisms is described. The system and method described herein include a plurality of sensors, a thermal control system, and a controller means coupled to the plurality of sensors and the thermal control system for aiding in the diagnosis of a respiratory dysfunction.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: January 8, 2013
    Assignee: DEKA Products Limited Partnership
    Inventors: David E. Altobelli, Benjamin W. Jones, Jr., Derek G. Kane, Gregory R. Lanier, Jr., Paul R. Marquis, Eric M. Soederberg
  • Patent number: 8344942
    Abstract: Range and Doppler ambiguities are common in radar, lidar, and acoustic systems. Resolving these ambiguities is important to achieve desirable geolocation and image quality performance in these systems. A new method is described to iteratively resolve the ambiguities. For Doppler ambiguity applications, a first PRF value and an initial Doppler frequency search window are selected. A new PRF is determined based on the ratio of the initial search window to the first PRF. The radar data of the first pair of PRF's is used to determine two modulo Doppler estimates. The modulo Doppler estimates are used to determine a new Doppler estimate with a confidence interval smaller than the first search window. The ratio of the new Doppler search window to the first PRF, is used to determine the next PRF. This process is iterated until the new Doppler search window is less than the first PRF.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: January 1, 2013
    Assignee: Raytheon Company
    Inventors: Michael Yih-Hwa Jin, Chi-Yung Chang
  • Patent number: 8343042
    Abstract: An endoscopic coupler by which the rotary and/or linear motion of an external ring is transferred via magnetic interaction of specially configured continuous plastic magnets to a lens resident in a hermetically sealed housing to effect focusing and/or zooming action of the lens without mechanically breaching the integrity of the hermetic seal thereby making the coupler particularly suitable for withstanding the rigors of autoclaving.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: January 1, 2013
    Assignee: Lighthouse Imaging Corporation
    Inventors: Dennis C. Leiner, Michael Bush
  • Patent number: 8343939
    Abstract: The present inventors discovered that PKC? is necessary for VEGF signaling through PI3K/Akt-dependent pathways and is involved in MAPK-dependent pathways, thus regulating eNOS activity and DNA synthesis, respectively. Thus differential manipulation of PKC? activity can be used to modify VEGF effects in conditions in which modulation of angiogenesis is desirable (e.g., for treatment of diabetic proliferative retinopathy or to enhance angiogenesis for treatment of peripheral and myocardial ischemia).
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: January 1, 2013
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Christian Rask Madsen, George Liang King
  • Patent number: 8329643
    Abstract: The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administration of the peptide of the present invention. Furthermore, the present invention relates to the modulation of the expression of cytokines effected as part of an inflammatory response by administration of the peptide of the present invention.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: December 11, 2012
    Assignee: Trustees of Boston University
    Inventors: Salomon Amar, Xiaoren Tang
  • Patent number: 8323901
    Abstract: This invention relates to novel nucleic acid-based probes and methods for detecting Plasmodium parasites in biological samples as well as detecting different Plasmodium parasites selectively from one another.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: December 4, 2012
    Assignee: ID-Fish Technology, Inc.
    Inventors: Jyotsna S. Shah, Danuta Wronska, Helena Weltman, Nick Harris, Suzanne Scherini-Ward, Olivia Mark
  • Patent number: 8323967
    Abstract: This invention relates to methods and compositions for enhancing hematopoietic stem cell mobilization by inhibiting early growth response-1 (egr1) activity.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: December 4, 2012
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Amy Wagers, Irene Min
  • Patent number: 8324103
    Abstract: The invention relates to a method of providing a planar substrate with electrical through connections (vias). The method comprises providing a hole in said substrate and a treatment to render the substrate surface exhibiting a lower wettability than the walls inside the hole. The planar substrate is exposed to a molten material with low resistivity, whereby the molten material is drawn into the hole(s). It also relates to a semiconductor wafer as a starting substrate for electronic packaging applications, comprising low resistivity wafer through connections having closely spaced vias.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: December 4, 2012
    Assignee: Silex Microsystems AB
    Inventor: Tomas Bauer
  • Patent number: 8323749
    Abstract: The invention relates to a process for applying a liquid UV-curable primer sealant to natural stone tiles and related articles followed immediately by the exposure to a requisite amount of low intensity UVA-type UV radiation to partially cure the primer sealant. The partial curing, or pre-setting, of the primer sealant enables control of the ultimate depth of penetration of the primer sealer into the natural stone tiles and natural stone articles of which many examples are quite porous. Because the low level UV irradiation is instantaneous after the primer sealant application the level of primer sealant penetration into the natural stone surface is regulated. The pre-curing of the primer sealant is conducted to intentionally solidify or immobilize the sealant that has actually penetrated into the natural stone surface. The uppermost layers of the primer sealant are left in a semi-liquid or uncured state to allow for wetting and intermingling by the top sealant once it is applied.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: December 4, 2012
    Assignee: Questech Corporation
    Inventors: Roger Questel, Larry Wasowski, Dorian C. Guptill, David Pelletier
  • Patent number: 8319452
    Abstract: In some examples, a dimming protocol detection technology includes methods and apparatuses. In other examples, the technology includes a dimmer configured to transmit a dimming input signal. The dimming input signal is in a dimming protocol. The technology further includes a light fixture. The light fixture includes a plurality of lights and a dimming protocol detection module configured to detect the dimming protocol received in the dimming input signal. The dimming protocol is detected from a plurality of dimming protocols. The light fixture further includes a light dimming control module configured to control the plurality of lights based on the detected dimming protocol.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 27, 2012
    Assignee: Lumenpulse Lighting, Inc.
    Inventors: Yvan Hamel, Gregory Campbell
  • Patent number: 8313915
    Abstract: The present invention relates, in one aspect, to the detection of Lyme disease in canines by detecting the peptide or antibodies to an infection specific peptide after challenge with B. burgdorferi. The 20 kDa peptide is not detectable in human sera samples after challenge or infection with B. burgdorferi and, as such, appears to be specific for canines and suitable for the consistent detection of Lyme disease in canines at time points earlier that possible with prior art methods.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: November 20, 2012
    Assignee: Gundersen Lutheran Medical Foundation, Inc.
    Inventor: Steven M. Callister
  • Patent number: 8315472
    Abstract: A method for reducing dimensionality of hyperspectral images may include receiving a hyperspectral image having a plurality of pixels. A basis vector set including a number of members may then be established, wherein each of the members comprises a basis vector. For each of the plurality of pixels, a spectral vector for the pixel may be read and decomposed with the members of the basis vector set to derive a residual vector for the pixel. A basis vector for the pixel may then be added to the members of the basis vector set if the residual vector for the pixel has a magnitude exceeding a predetermined threshold, and the basis vector set may then be optimized to eliminate one of the members of the basis vector set, whereby the optimized basis vector set includes the number of members. A system configured to perform the method may also be provided.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: November 20, 2012
    Assignee: Raytheon Company
    Inventors: Ian S. Robinson, Anthony M. Sommese
  • Patent number: 8314506
    Abstract: An apparatus and method for converting wave energy using the relative rotational movement between two interconnected float assemblies and the relative rotational movement between each of the float assemblies and a spar which extends from a connection with the float assemblies at the water surface into the water.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: November 20, 2012
    Assignee: Columbia Power Technologies, Inc.
    Inventors: Kenneth Edward Rhinefrank, Bradford Storrs Lamb, Joseph Horan Prudell, Alphonse Aloysius Schacher
  • Patent number: 8309302
    Abstract: Methods and processing reagents for improving washing and aging a biological sample in an assay are disclosed. The processing reagents comprise an aqueous base reagent and a low vapor pressure composition in sufficient amount to raise the boiling point of the base reagent. The methods comprise applying the base reagent and low vapor pressure composition to the biological sample for use at an elevated temperature.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: November 13, 2012
    Assignee: Abbott Laboratories
    Inventors: Robert W. Jaekel, Anna O'hare, Larry E. Morrison
  • Patent number: 8308960
    Abstract: The invention relates in a general aspect to a method of making vertically protruding elements on a substrate, said elements having a tip comprising at least one inclined surface and an elongated body portion extending between said substrate and said tip. The method comprises an anisotropic, crystal plane dependent etch forming said inclined surface(s); and an anisotropic, non crystal plane dependent etch forming said elongated body portion; combined with suitable patterning processes defining said protruding elements to have a predetermined base geometry.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: November 13, 2012
    Assignee: Silex Microsystems AB
    Inventors: Edvard Kälvesten, Thorbjörn Ebefors, Thierry Corman
  • Patent number: 8306063
    Abstract: A system and method for identifying UDP packets on an IP network as candidates for characterization as packets of a RTP stream. UDP packets are identified at a point on the IP network, and for each identified UDP packet 1) it is determined if a version number in a RTP header field in the payload of the UDP packet equals a predetermined value, 2) determined if a packet length associated with the UDP packet is within a predetermined range, 3) determined if a payload type RTP header field within the payload of the UDP packet is within a predetermined range. If all the criteria are satisfied, then the identified UDP packet is characterized as a candidate RTP packet. It is then determined if the candidate RTP packet belongs to a previously detected RTP stream, or to a newly encountered RTP stream. A stream data store is then updated using the information in the RTP header of the candidate RTP packet.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: November 6, 2012
    Assignee: EXFO Services Assurance, Inc.
    Inventors: Muhammet Erdal, Kaynam Hedayat
  • Patent number: 8306213
    Abstract: Described are computer-based methods and apparatuses, including computer program products, for skill and level assignment. In some examples, the method includes providing for display of a graphical user interface (GUI) with one or more sets of graphical objects. Each set of graphical objects corresponds to a decision factor and each graphical object in each set of graphical objects corresponds to a level of the decision factor. The method further includes receiving an assignment configuration for a contact routing device. The assignment configuration is generated based on the one or more sets of graphical objects and associated one or more agents. The method further includes routing the contact to the selected one or more contact agents based on the assignment configuration.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: November 6, 2012
    Assignee: Google Inc.
    Inventors: Juan Vasquez, Steve Osborn, Ivo Daniel Carreira de Abreu
  • Patent number: 8306613
    Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: November 6, 2012
    Assignee: EyeGate Pharma S.A.S.
    Inventor: Pierre Roy
  • Patent number: 8300276
    Abstract: In certain embodiments, compensating for misalignment comprises receiving, at a detector array, electromagnetic (E-M) radiation from a target object. The detector array comprises time delay and integration (TDI) detectors organized into segments. Each segment comprises one or more rows of detectors perpendicular to a designed scan axis, and comprises columns of detectors parallel to the designed scan axis. The detector array moves in a relative scan direction relative to the target object. The following is performed for each segment and for each column of each segment. If there is misalignment at a segment, a signal is passed to a correcting next column of a next segment in the direction of the misalignment, where the signal accumulates scan data of a portion of the target object. Otherwise, the signal is passed to a designed next column of the next segment in the direction of the designed scan axis.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: October 30, 2012
    Assignee: Raytheon Company
    Inventor: John L. Vampola