Abstract: Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope. In addition, the nucleic acid molecule comprises a second expressible nucleic acid sequence encoding an antigen presentation enhancing hybrid polypeptide.

Abstract: An extrusion nozzle including an outlet port having a single opening with a first region, second region, and a pinched region between the two. The pinched region reduces the dimensions of the extrudate in relation to the dimensions associated with the first and second regions. In that way, the extrudate is joined together but may be easily separated into two separate pieces with dimensions related to the dimensions of the first and second region.

Abstract: The present invention is a tool for scribing tile, including a base member that defines a substantially planar surface, preferably rectangular in design, and more preferably with a small cutout in one end for particular applications. The base member preferably approximates the size of a tile to be laid. The base member is slidably coupled to a series of edge members and center members that are movable with respect to each other as well as the base member. The edge and center members are slidably fastened to the base member, thus permitting the tool to mimic a number of shapes and sizes depending upon the shape and size of tile to be cut.

Abstract: It has now been discovered that certain mutant forms of pro-urokinase (“pro-UK”), such as so-called pro-UK mutant “M5” (Lys300?His), perform in the manner of pro-UK in lysing “bad” blood clots (those clots that occlude blood vessels), while sparing hemostatic fibrin in the so-called “good” blood clots (those clots that seal wounds, e.g., after surgery or other tissue injury). Thus, these pro-UK mutants are excellent and safe thrombolytic agents. These advantages allow them to be used in a variety of new methods, devices, and compositions useful for thrombolysis and treating various cardiovascular disorders in clinical situations where administration of other known thrombolytic agents has been too risky or even contraindicated.

Abstract: An air processing cylinder useful in drying, curing, thermal bonding, cooling, and web transferring materials such as fabrics, papers, and the like. Air is exhausted out of the cylinder surface through a plurality of conduits equipped with distribution means for profiling the flow of air. The drying cylinder further includes a duct network on its outer shell for exhausting air out of one axial area only or, alternatively, the drying cylinder may contain multiple duct networks for exhausting air out of several axial areas, each having its own flow characteristics.

Abstract: Disclosed is a removable template for recording custom settings on an audio amplification system, or components thereof. The template comprises a template blank shaped for accommodation by an amplifier control panel, the template blank having cut-outs or bores facilitating the application of the template to the amplifier control panel, and the subsequent operation of said control panel. The template blank further comprises a surface for marking control settings and related indicia.

Abstract: Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent application aperture; a sample collection matrix disposed between the rear panel and the front panel, the sample collection matrix being in communication with the sample and solvent application apertures of the front and rear panels; and at least one insertable test strip containing a reagent enabling detection of the analyte of interest.

Abstract: A portable breakwater system for use in a body of water includes first and second support members adapted to be positioned on the floor of the body of water and a curtain attached between the first and second support members. The first and second support members allow the curtain to freely rise in response to a wave in the body of water so as to attenuate the wave. Each support member includes a base plate and a frame assembly extending upwardly from the base plate. The base plates can be anchored to the water floor with one or more weights. The frame assemblies include pivoting or telescoping sections that permit the curtain to rise in response to a wave. Alternatively, the curtain can be attached to pre-existing underwater structure, such as the support members of a dock located in the body of water. In this case, the curtain is attached to the support members via attachment sleeves that are slidingly mounted on the support members.

Abstract: An apparatus for drying a travelling wet fibrous web is provided which comprises a rotating air-permeable drum. The drum is at least partially surrounded by a hood which has an interior space for receiving a flow of air and directing the flow of air through a permeable inner wall towards the outer surface of the drum. At least a portion of the hood is divided into individual sections in a cross-machine direction. Apparatus is provided for supplying a flow of drying air at a first temperature to the hood, and for supplying profiling air at a selected different temperature different from the first temperature to at least one of the individual sections.

Abstract: A faucet clamp for retaining a faucet to a sink has first and second jaws that are pivoted together by a hinge. The jaws have internal clamping surfaces which include a thread-engaging surface, for example a compliant liner. The thread-engaging surface engages the threads of a faucet pipe extending from the faucet base and clamps the faucet to the sink. The jaws of the faucet clamp pivot to an open position for installation or removal over the faucet pipe.

Abstract: Disclosed are modified red blood cells which function as deployment platforms for important biomolecules. Such modified red blood cells can confer, for example, in vivo protection against exposure to an otherwise lethal nerve agent.

Abstract: Provided herein are methods for the biosequestration and organic assimilation of a gas that contributes to the greenhouse effect. In these methods, a gas that contributes to the greenhouse effect is introduced into a peat bog where it is thereafter sequestered and organically assimilated. A capture method may be employed in conjunction with the present invention to enable transport of the gas from an industrial site to a processing facility located at or near a peat bog. Once transported to a relevant processing facility, the captured gas may be regenerated and thereafter introduced into the peat bog for its biosequestration and organic assimilation. In the context of the present invention, the gas may be a greenhouse gas (GHG), sulfur oxide (SOx) gas, and/or volatile organic compound (VOC).

Abstract: An extended release analgesic for controlling pain comprised of an opioid or non-opioid analgesic drug ionically bound to hyaluronic acid, poly-?-glutamic acid or other ionic polymers, and injected into a body either subcutaneously, intramuscularly or intraperitoneally, utilizing counter-ions of different valences to control the rate of release into the body.

Abstract: An arrangement for the detection of relative movements of two objects with four measuring cells as vertical measuring device for the detection of a relative movement perpendicular to an imaginary plane, with the measuring cells being arranged in such a manner that their vertical projections onto the plane are arranged at an identical angular distance from each other about a centre. Further, a force and/or moment sensor with a first board and a second board which are elastically connected with each other and movable relative to one another.

Abstract: A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease.

Abstract: A fastener, such as a nail or staple, includes a fastener body having an impact surface and a plug of filler material joined to the impact surface. The plug of filler material fills the hole made by the fastener body when the fastener is driven into a workpiece. Many types of fasteners can be used, such as nails and staples. In the case of a nail, the plug of filler material would be joined to the nail head. In the case of a U-shaped staple, the plug of filler material would be joined to the cross member joining the staple legs. The filler material can be a wide variety of materials such as wood putty, acrylic sealant, fiberglass resin fillers, epoxy adhesives, and plastic.

Abstract: Disclosed is a fishing gear recovery device and methods of use. The fishing gear recovery device of the present invention includes a recovery line housing, which is preferably produced from flexible tubular plastic stock. Attachments points are provided in the recovery line housing for the attachment of a recovery line, and biodegradable connectors. Additionally, the recovery device includes a buoyancy providing element.

Abstract: Disclosed are bispecific antibodies comprising a first antibody binding specificity which confers the ability of the bispecific antibody to cross the blood-brain barrier, and a second antibody specificity conferring the ability of the bispecific antibody to bind to a ?-amyloid epitope. Also disclosed are methods for inhibiting the formation of ?-amyloid plaques in the brain of a human, of promoting the disaggregation of a preformed ?-amyloid plaque. Such methods recite the administration of a bispecific antibody.

Abstract: The invention relates to a digital information system (10) for displaying information on at least one display means with the aid of at least one projector (22). The exposures are presented at places accessible to and frequented by a general public. The information system (10) includes external information mediators (24) and information is controlled dynamically through the medium of a communication interface (26) and through the medium of an exposure handler in a central computer (28). The inventive system also include a communication interface (14) against an elective number of station computers (34) having connected projector computers (38) which control projectors (22) for displaying pictures or exposures. The station computers (34) and peripheral equipment are situated at mutually distanced places.