Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.

Abstract: The hydrocarbon light-off time in engine exhaust is reduced by employing a hydrogen oxidation catalyst, a CO oxidation catalyst of light-off temperature for CO and/or hydrogen below ambient temperature, and sufficient oxygen and sufficient CO and/or hydrogen in the exhaust that the exothermic reaction of the oxygen with the CO and/or hydrogen over the CO oxidation catalyst generates enough heat to raise the temperature of the CO oxidation catalyst to at least the light-off temperature of the hydrocarbon oxidation catalyst.

Abstract: The invention relates to a process for the preparation of a polymer from ethylene, an .alpha.-olefine and optionally a diene, according to which these monomers are polymerized under the influence of a metallocene catalyst, the polymerization taking place in the presence of a catalyst comprising a specific 2-indenyl metallocene, resulting in a bimodal, elastomeric polymer with a molecular weight distribution of more than 3.5, under such reaction conditions that the amount of water in the polymerization medium is smaller than 0.5 ppm.The invention also relates to polymers with a specific branching index.

Abstract: A tobacco smoke filter material comprises a fibrillated cellulose ester fiber with an average fiber diameter of 15 to 250 .mu.m and a BET specific surface area of 0.5 to 4.5 m.sup.2 /g. The fibrous cellulose ester content of the material may for example be not less than 20 weight %. The cellulose ester fiber is provided by, for example, extruding a cellulose ester solution from a nozzle into a precipitating agent for the particular cellulose ester and subjecting the extrudate to a shear force. This filter material can be used in the form of, for example, a filament, web or sheet to provide a tobacco smoke filter which assures good smoking qualities and excellent wet disintegratability.

Abstract: The present invention is related to a composite microporous polyolefin membrane having a high separation, a high flux and a high strength, comprising a microporous layer, b-layer, providing a reinforcing function, the b-layer being stacked on at least one surface of a microporous layer, a-layer, providing a separate function, wherein micropores in a-layer and b-layer are mutually interconnected inside of the layer and also between layers, thereby forming micropores connected from one surface of the membrane to the other surface thereof, and the ratio of the mean distance Da between microfibril bundles of micropores existing in a-layer to the mean distance Db between microfibril bundles of micropores existing in b-layer is in the range of 1.3.ltoreq.Db/Da.ltoreq.15, and furthermore all of the inner and the outer surfaces of the composite membrane and the surface inside of micropores are coated by a thin film of a hydrophilic copolymer.

Abstract: A propylene random copolymer and a film laminate thereof is described having excellent blocking resistance and transparency and substantially maintaining favorable low-temperature heat-sealing properties after corona discharge treatment. The propylene random copolymer of the invention includes a propylene component and an .alpha.-olefin component having 4 to 10 carbon atoms, wherein the content of the .alpha.-olefin component is in the range of about 6% to about 40% by weight, the intrinsic viscosity ?.eta.! measured in tetralin at 135.degree. C. is not lower than about 0.45 dl/g and not higher than about 5.0 dl/g, and the melting point (Tm) measured by a differential scanning calorimeter and the content of 20.degree. C. xylene soluble fraction (CSX) fulfill a relationship ofTm.ltoreq.140-35.693 log.sub.10 (CXS).

Abstract: A method wherein a number of cylinders (2, 3; 1, 4) are grouped on a same exhaust gas manifold (8, 10) such that the pressure in the exhaust pipe (1e . . . 4e) undergoes time-dependent fluctuations of substantial amplitudes, and the exhaust valve (6) of a cylinder (1) is opened during induction or filling thereof (i.e. adjacent to the bottom dead center) so that, in a given engine speed range, a phase (28) of low instantaneous exhaust pressure prevailing in the exhaust pipe enables the inlet pipe (1a)/cylinder (1)/exhaust pipe (1e) to be scavenged while the inlet valve (5) and the exhaust valve (6) are simultaneously open. The phase (29) of high instantaneous exhaust pressure, caused by another cylinder, after the inlet valve (5) has closed and while the exhaust valve (6) is still open, is used for post-charging the cylinder (1) with air (A) previously stored in the exhaust pipe (1e).

Abstract: A supporting assembly for a mixing bowl is provided including a support having first and second opposing edges and at least one open end defining an interior space. First and second holding members are provided, each holding member covering at least a portion of an associated edge of the support. The holding members are constructed and arranged such that when the supporting assembly is disposed with the first holding member in contact with a planar surface and a mixing bowl is at least partially disposed in the interior space with the second holding member contacting a peripheral surface of the mixing bowl, friction between the mixing bowl and the second holding member and between the planar surface and the first holding member holds the bowl stationary with respect to the planar surface when contents of the mixing bowl are mixed.

Abstract: Process for the preparation of 3-phenylpropanal in which cinnamaldehyde is hydrogenated with the aid of a Pd-containing catalyst in the presence of a small amount of water. A high yield and a high selectivity are obtained in a commercially attractive process. The reaction mixture obtained can without intermediate further processing be subjected to an oxidation in which the cinnamaldehyde is oxidized to 3-phenylpropionic acid with a high degree of conversion and a high selectivity. The combination of the two process steps constitutes a simple, commercially attractive process for the preparation of 3-phenylpropionic acid using cinnamaldehyde as a starting material. The resulting 3-phenyl-propionic acid product may serve as an intermediate reagent in the synthesis of anti-viral pharmaceuticals, particularly HIV protease inhibitors.

Abstract: A composition comprises a cellulose acetate or other cellulose ester, and an anatase-type titanium oxide having (1) a specific surface area of not less than 30 m.sup.2 /g, (2) a primary particle size of 0.001 to 0.07 .mu.m, or (3) a specific surface area of not less than 30 m.sup.2 /g and a primary particle size of 0.001 to 0.07 .mu.m. For improving the photodegradability and the dispersibility, the surface of the titanium oxide may be treated with a phosphoric acid salt or other phosphorus compound, a polyhydric alcohol, an amino acid or others. Use of a low-substituted cellulose ester with an average substitution degree not exceeding 2.15 insures high biodegradability. The composition may further contain a plasticizer and/or an aliphatic polyester, a biodegradation accelerator (e.g. organic acids or esters thereof). The degradable cellulose ester composition is highly photodegradable and moldable and hence useful for the manufacture of various articles.

Abstract: The invention relates to a powder paint binder composition. The binder composition comprises a hydroxyl functional polymer and a crosslinker containing blocked isocyanate groups. The crosslinker includes (i) a crystalline compound containing blocked isocyanate groups and ii) an amorphous compound containing blocked isocyanate groups. Preferably the crosslinker is a mixture of blocked hexamethylene diisocyanate trimer and blocked 1,6-hexamethylene diisocyanate.

Abstract: A polymeric composition in which (D) a phenol antioxidant having a specific skeleton 5-t-butyl-3-methyl-4-hydroxyphenyl, (C) a hindered amine photostabilizer having a molecular weight of not less than 400, and (D) a specific phosphorus compound dihydrooxaphosphaphenanthrene are included in (A) a polymeric compound. This polymeric composition is excellent in thermal oxidation degradation resistance and discoloration of coloring resistance in contacting with a combustion gas or the like.

Abstract: A liquid curable resin composition for optical fibers comprising a polymer (a) having a number average molecular weight of 5,000 or more and derived from at least two types of recurring ethylenic units, of which one type has a substituent group containing an ethylenically unsaturated group and the second type is substituted by a group --COOR.sup.3 (wherein R.sup.3 is a hydrogen atom or a hydrocarbon group having 1-30 carbon atoms), an aryl group, a cyano group, an alkyl group having 1-10 carbon atoms or by one or more halogen atoms.

Abstract: A family of high performance, large launch vehicle, solid propellants based on polyglycidyl nitrate elastomer binders. A clean, large launch vehicle, solid propellant based on a polyglycidyl nitrate elastomer binder, ammonium nitrate oxidizer and aluminum or magnesium fuel optimizes at low solids levels and produces essentially no HCl or chloride ion in the exhaust.

Abstract: A family of high performance, space motor, solid propellants based on polyglycidyl nitrate elastomer binder, ammonium perchlorate oxidizer and beryllium or beryllium hydride fuel which do not require the presence of plasticizers. A high performance, space motor, solid propellant based on a polyglycidyl nitrate elastomer binder, ammonium perchlorate or hydroxy ammonium perchlorate and beryllium or beryllium hydride optimizes performance at low solids levels.

Abstract: A process for producing a fiber-reinforced thermoplastic resin molded article including: (a) projecting a sheet-holding member from a cavity face of a lower mold towards a cavity face of an upper mold, (b) placing a heated fiber-reinforced thermoplastic resin sheet on the sheet-holding member, (c) closing the upper and lower molds, (d) in the step of closing the upper and lower molds, putting the sheet-holding member into the lower mold before the cavity face of the upper mold contacts with the resin sheet, (e) maintaining the upper and lower molds in a closed state, and (f) opening the upper and lower molds and removing the molded article. A fiber-reinforced thermoplastic resin molded article which has a good surface appearance and, if any, whose protrusions such as ribs and bosses are sufficiently filled with thermoplastic resin and reinforcing fibers, can be produced, without using an additional thermoplastic resin sheet and without repeating the molding process.

Abstract: A water-in-oil (W/O) emulsion ink for stencil printing having an oil phase and a water phase is provided, in which a pearlescent pigment is contained in said oil phase and/or said water phase in an amount of 1 to 20% by weight of the total weight of said emulsion ink. The pearlescent pigment has an average particle size of 1 to 30 .mu.m. The pearlescent pigment preferably has a hiding power of 1,000 cm.sup.2 /g or lower. A colorant may be contained in at least one of said oil phase and said water phase. The oil phase preferably contains a non-volatile solvent, a volatile solvent, and an emulsifier, and optionally a resin. The water phase preferably contains an oil-in-water (O/W) emulsion of resin and/or a water soluble resin. The emulsion ink provides glossy printed images regardless of types of paper, and is quick in drying.

Abstract: A process for producing granules from a liquid composition which includes the steps of applying the liquid composition onto solid particles of the same composition circulating in the granulation zone of a granulator, thereby causing particles to grow, discharging a stream of grown particles from the granulation zone, cooling this stream in a cooler, and dividing the stream exiting the cooler, in a size-sorting apparatus, into three streams of grown particles based on size. The stream of desired-sized particles is withdrawn for future use or processing, the stream of undersized particles is returned to the granulation zone and the stream of oversized particles is sent to a size-reducing apparatus for crushing, with the resulting crushed particles recycled back to the cooler located downstream of the granulator and upstream of the size-sorting apparatus.