Abstract: A method and apparatus for significantly increasing the solubility and dispersibility of consumer products such as food products, botanicals, cosmetic ingredients and medical products is disclosed. The method involves applying a continuous stream of oxygen-containing, i.e., OX gas to a material in a sealed chamber. The continuous stream of OX gas is prepared in an OX generation cell, which contains a means for generating the OX gas at a pressure less than 20 lbs/in2 using, for example, one or more of the following: corona discharge, high frequency electrical discharge, ultraviolet light, x-ray, radioactive isotope and electric beam. The apparatus contains: (a) a chamber; (b) a vacuum pump coupled to the chamber; (c) an OX generation cell, wherein the OX generation cell contains an OX generator capable of generating OX at a pressure less than 20 lbs/in2.

Abstract: A self-propelled rotary excavator having a plurality of booms forming a boom assembly attached to a chassis, with a rotary cutting device attached to the end of the boom assembly. The boom assembly positions the rotary cutting device at a desired position in regard to the chassis or moving portion of the self-propelled rotary excavator. The position of the rotary cutting device is maintainable (preferably controlled by lasers) so as to provide a ditch which has a constant grade regardless of the undulations of the land upon which the self-propelled rotary excavator traverses. An operator of the self-propelled rotary excavator can also independently control both the depth of the cut produced by the rotary cutting device and the distance in a direction perpendicular to the depth of the cut produced by the rotary cutting device.

Abstract: A gaseous blend of Ox and a method for significantly reducing the biological load on consumer products such as food products, botanicals and cosmetic ingredients is disclosed. The gaseous blend of Ox consists at least in part of O3. The method involves applying a continuous stream of oxygen-containing, i. e., Ox, gas to a material at a predetermined temperature, pressure and relative humidity. The continuous stream of Ox gas is prepared in an Ox generation cell, which contains a means for generating the Ox gas at a pressure less than 20 lbs/in2 using, for example, one or more of the following: corona discharge, high frequency electrical discharge, ultraviolet light, x-ray, radioactive isotope and electric beam.

Abstract: An easily installable signal enhancement addition for a satellite dish, and method for using an installed dish as a reference that allows installation of the enhancement without re-acquiring the satellite signal or re-aiming the dish. In one variation, the enhancement includes a reflector addition fitted with fasteners that locate the reflector against the existing dish, and use of the original feed horn, which is relocated using a support extension. This variation avoids the “shadow” of the feed horn and its support arm, and minimizes the reflective surface area at the lower end of the dish, which reduces collection of such interfering material as snow, rain, and debris. In variations using increased reflector size, the enhancement reduces loss of signal during inclement weather or in other situations in which the satellite signal is partially blocked. In one variation, the added reflector is a standard parabolic reflector superimposed over the original reflector, or replacing it on its mount.

Abstract: An attenuated, avirulent recombinant vaccine providing challenged protection against channel catfish virus comprises deletion of gene 50. Gene 50 encodes a secreted glycoprotein. Removal of gene 50, or replacement of gene 50 with foreign genetic material, provides a vaccine with which induces virus specific immunity against CCV disease.

Abstract: A kit for detecting a first substance in a sample including a stabilized 1,2-dioxetane bearing an enzyme-labile substituent, which is destabilized and caused to decompose by contacting the 1,2-dioxetane with an enzyme under conditions which cause the enzyme to cleave the enzyme-labile group from the dioxetane, thereby yielding a negatively charged oxygen anion bonded to the 1,2-dioxetane, which causes the 1,2-dioxetane to decompose without input from an external excitation energy source, the decomposition being accompanied by chemiluminescence; and a second component selected from the group consisting of a specific affinity substance (e.g., an antigen, an antibody or a nucleic acid probe) and an enzyme which destabilizes said 1,2-dioxetane.

Abstract: There is disclosed a complex and a combination of the glycosylated polypeptide fetuin and a therapeutically active small molecule compound having a net positive charge at physiological pH. The presence of fetuin as a drug complex or in combination with the therapeutically active small molecule compound enhances therapeutic activity of the small molecule compound. The present invention further provides a means for screening for therapeutically active small molecule compounds by means of binding to fetuin.

Abstract: A probe for measuring the viscosity and/or temperature of high temperature liquids, such as molten metals, glass and similar materials comprises a rod which is an acoustical waveguide through which a transducer emits an ultrasonic signal through one end of the probe, and which is reflected from (a) a notch or slit or an interface between two materials of the probe and (b) from the other end of the probe which is in contact with the hot liquid or hot melt, and is detected by the same transducer at the signal emission end. To avoid the harmful effects of introducing a thermally conductive heat sink into the melt, the probe is made of relatively thermally insulative (non-heat-conductive) refractory material. The time between signal emission and reflection, and the amplitude of reflections, are compared against calibration curves to obtain temperature and viscosity values.

Abstract: The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

Abstract: A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclosed is a kit for conducting a bioassay for the presence or concentration of a biopolymer comprising a) an enzyme complex; b) a 1,2-dioxetane; and c) AttoPhos™.

Abstract: A method and apparatus for significantly reducing the biological load on consumer products such as food products, botanicals, cosmetic ingredients and medical products is disclosed. The method involves applying a continuous stream of oxygen-containing, i.e., Ox, gas to a material in a sealed biological burden reduction chamber.

Abstract: A radiation-sensitive resin composition comprising (a) a resin represented by a copolymer of p-hydroxystyrene and t-butyl (meth)acrylate and a copolymer of p-hydroxystyrene and p-t-butoxystyrene, (b) a photoacid generator, and (c) a quaternary ammonium salt compound represented by tetramethylammonium adamantanecarboxylate, tetramethylammonium oxalate, tetraethylammonium pyruvate. The radiation-sensitive resin composition is capable of producing a rectangular resist pattern while preventing the top edge of the pattern from rounding, which is a big problem in microprocessing of design dimensions of about 0.20 &mgr;m with a thin film. The radiation-sensitive resin composition is highly sensitive to deep ultraviolet radiation, X-rays, and charged particle rays and exhibits excellent sensitivity, resolution, and the like.

Abstract: A water-tight fiberglass septic tank is strong enough to withstand live loads. The fiberglass septic tank is preferably designed with integral ribs to for structural strength. In one preferred embodiment, the tank is made in two unequal halves. The lower half comprises the major portion of the tank and includes a bottom, two endwalls and two sidewalls. The upper half comprises a cover. This arrangement allows the horizontal seam to be placed above the internal waterline, thereby protecting the seam from exposure to sewage. At least one of the endwalls includes a raised top portion that allows a pipe to be located near the top of the lower portion without passing through the seam between the upper and lower portions of the tank. The endwalls are also curved to allow for angled inlet and outlet pipe connections. The ribs are preferably internal and hollow. The lower portion of the tank is also preferably flat bottomed. A provision has been made for a self-locating baffle if required.

Abstract: A method of populating multiple data marts in a single operation from a set of transactional data held in a database in a single aggregation process, in which aggregate values are calculated only once, a determination is made as to which output data marts required the aggregate value, and the aggregate values are output to the appropriate data marts. Dimension data associated with the output aggregate records is also output to the appropriate data marts.

Abstract: A method for binding tumor emboli circulating in the blood of mammals is provided by oral or intravenous administration of a modified alginate, prepared from alginic acid by thermal degradation/hydrolysis or enzymatic degradation. The modified alginate has a molecular weight of no more than 40,000 daltons, and is water soluble.

Abstract: A radiation-sensitive resin composition comprising a solution of an alkali-soluble resin and a radiation-sensitive compound in a solvent comprising a monooxymonocarboxylic acid ester. This composition has a high storage stability (i.e., a very small amount of fine particles are formed during storage) and is suited for use as a resist for making integrated circuits.

Abstract: Provided are cyclized peptides with a constrained region(s) having an &agr;-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.

Abstract: There is disclosed a cancer malignancy diagnostic assay comprising obtaining a sample of a body fluid or tissue, performing a sequence identity assay to look for the presence of iPFK-2 specific sequences; an anticancer pharmaceutical composition comprising a specific antisense oligonucleotide to the inventive isolated iPFK-2 sequence and a pharmaceutically acceptable oligonucleotide carrier; and a method for finding therapeutically active anti-cancer compounds comprising screening compounds for activity to inhibit iPFK-2, preferably kinase activity.

Abstract: There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present pharmaceutical compositions are able to inhibit the inhibitory effect of spermine upon macrophage function, and thus prevent spermine-induced immunosuppression.