Abstract: In this application is described the characterization Borrelia burgdorferi lipoprotein BBK07, an in vivo expressed and surface-exposed immunogen. BBK07 expression in the infected hose can be detected at the RNA and protein level as early as the first week of infection. Therefore, described is the use of BBK07 antigen and immunogenic epitopes as well as bbk07 nucleotides in methods and kits for the diagnosis of Lyme disease.
Type:
Grant
Filed:
February 17, 2010
Date of Patent:
December 25, 2012
Assignee:
University of Maryland, College Park Office of Technology Commercialization
Abstract: In this application is described the identification of genetic variants that contribute to susceptibility to drug-induced vestibular dysfunction, more particularly, GM-induced vestibular dysfunction. Methods, compositions and kits for determining whether an individual has susceptibility for drug-induced vestibular dysfunction are disclosed.
Type:
Grant
Filed:
March 28, 2008
Date of Patent:
May 3, 2011
Assignee:
University of Maryland College Park
Inventors:
Stephen M. Roth, John J. Jeka, Scott M. Williams
Abstract: The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into the genome of different hosts. Methods of using the vectors and transformed hosts are described.
Type:
Grant
Filed:
September 14, 2007
Date of Patent:
February 22, 2011
Assignee:
University of Maryland, Baltimore
Inventors:
Diana M. Oram, Mark Oram, Joelle Woolston