Abstract: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.
Type:
Grant
Filed:
August 24, 2007
Date of Patent:
February 22, 2011
Assignees:
Van Andel Research Institute, Fred Hutchinson Cancer Research Center
Inventors:
Boliang Cao (Brian), George F. Vande Woude, Beatrice S. Knudsen
Abstract: A conversion kit for converting a snowmobile into a wheeled road vehicle, includes first and second front wheel assemblies. First and second spindle plates have a mount bracket, a strut bracket, a torsion bar bracket, and first and second kingpin assemblies. The kingpin assemblies on the first and second spindle plates connect with the first and second front wheel assemblies. A trailing arm is integrally connected with the spindle plate and extends rearwardly therefrom. A rear wheel assembly is rotatably connected with the snowmobile and has a rear wheel sprocket fixedly connected thereto. A drive shaft is connected to a power source on the snowmobile and a drive belt connects the drive shaft to the rear wheel sprocket.
Abstract: A method for carrying a plurality of food containers that includes an insulated housing having a closed bottom, a closed top located substantially vertically above the bottom, and at least one side wall having a first opening proximate the top of the housing and a second opening proximate the bottom of the housing, the first opening being sized to receive at least one meal container therethrough, the second opening being sized to allow removal of at least one meal container from within the housing as received within the housing from the first opening and to preclude simultaneous removal of all of the meal containers from within the housing, thereby limiting heat transfer from within the housing.
Type:
Grant
Filed:
July 15, 2010
Date of Patent:
February 22, 2011
Assignee:
Oliver Packaging and Equipment Company
Inventors:
Paul T. Dege, Jim C. Nensewitz, Edward W. Burmeister, Brian E. Ainsworth
Abstract: A lip closure device (105) for use with human remains includes a shaft (201) having a first end (205) that is substantially pointed and a second end (213) that is substantially blunt. One or more hooking notches (207, 215) are used for engaging with tissue inside the mouth of the human remains in order to maintain the lips into a substantially closed position.
Type:
Grant
Filed:
March 7, 2006
Date of Patent:
February 22, 2011
Inventors:
Darryl William Harper, Robert Selvy Harper, Jr.
Abstract: A magnetic electron exciter includes a rotor adapted to be rotated within a preselected range of rotational speeds, and having a plurality of magnets mounted therein preselected distances from the rotational axis of the rotor. A plurality of coils are positioned adjacent to the rotor, whereby rotation of the rotor creates an electrical current in the coils. First and second electrodes are spaced apart a predetermined distance, and are electrically connected with the coils to create an arc between the electrodes when the rotor is rotated relative to the coils.
Abstract: A scraper truck includes a main scraper mounted to a wheeled vehicle and side scrapers pivoted to the main scraper at its ends. The side scrapers are pivotally movable between extended lateral positions where the side scrapers extend outboard of the opposite ends for collecting debris located outboard of the vehicle's width, and a retracted position where the side scrapers are in overlapped juxtaposed storage positions close to and in front of the main scraper. The main scraper has a front face that is concavely shaped. The scraper mount defines a vertical pivot axis and the scraper assembly is rotatable about the vertical pivot axis upon striking an object toward an end of the scraper. A biasing mechanism is provided for biasing the scraper toward a centered forwardly-facing position, and a shear pin is configured to break prior to damage to the scraper or vehicle frame.
Abstract: An adhesive device used as a wound dressing, ingredient delivery device or IV hold-down in which inadvertent edge release of these devices along the periphery of the polymeric film layer is minimized when the handling layer, which is adhered to the polymeric film layer, is removed after application of the polymeric film layer to the patient.
Type:
Grant
Filed:
July 2, 2004
Date of Patent:
February 15, 2011
Assignee:
Corium International, Inc.
Inventors:
Michael G. Marcoux, David R. Johnson, Steven R. Klemm
Abstract: An automatic guided vehicle (AGV) and method has at least one AGV with a drive assembly, a rechargeable power source on-board the AGV configured to supply power to the drive assembly, and a controller on-board the AGV. The controller on-board the AGV is configured to substantially continuously monitor at least two conditions including an operating condition of the AGV, a state of charge of the power source, and an electrical power supplied for recharging the rechargeable power source, wherein the controller determines when the rechargeable power source of the AGV is to be recharged, and controls a recharging process of the power source based upon at least one of the monitored conditions.
Type:
Grant
Filed:
December 1, 2008
Date of Patent:
February 15, 2011
Assignee:
Savant Automation, Inc.
Inventors:
Jerry L. Redmann, Jr., Matthew L. Werner, Garry A. Koff
Abstract: A simultaneous movement system for a vehicle door includes a vehicle door having a door inner panel, first and second outboard members, first and second inboard members, first and second guide tracks, a third curved guide track, first and second points on the second outboard member, and first and second slide members. The first and second guide tracks are operatively mounted to the vehicle door. The third curved guide track may be operatively mounted to the vehicle door and is configured to receive a second point on the second outboard hinge arm. The first point on the second outboard hinge arm may be pivotally mounted on a second slide member.
Type:
Grant
Filed:
November 21, 2008
Date of Patent:
February 15, 2011
Assignee:
Ford Global Technologies, LLC
Inventors:
Adrian Nicholas Alexander Elliott, Jason Falenski, Dave Michael Lechkun, Craig Blust
Abstract: A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial/transient processing module, and a spectra processing module. The initial/transient processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The transient processing module may contiguously sample the ion detection signals at a rate of at least 1.5 GHz. The spectra processing module may generate spectra from the transients at a rate of at least 50 spectra per second. The initial processing module may be configured to have a sensitivity that is sufficient to detect a single ion received within one of over at least 100 transients and to detect and quantify a number of ions simultaneously striking said ion detector up to at least 10 simultaneously striking ions.
Type:
Grant
Filed:
December 11, 2008
Date of Patent:
February 8, 2011
Assignee:
Leco Corporation
Inventors:
Peter M. Willis, Michael C. Mason, Mark A. Wheeler, Viatcheslav B. Artaev, Julie R. Pitz
Abstract: A conformable pad (100) for use under an orthopedic brace includes an upper edge (101) having a straight dimension and a lower edge (108) having an uneven dimension with at least one wide section (101) and at least one narrow section (115). The pad (100) further includes a first edge (117) having a straight dimension and positioned adjacent to the at least one wide section (101) and a second edge (119) also having a straight dimension and positioned adjacent to the at least one narrow section (115) such that the first edge (117) is longer than the second edge (119). The invention is advantageous for use with orthopedic braces in order to prevent friction and irritation created by the brace against the user's skin.
Abstract: A computer controlled roll-forming apparatus is adapted to provide a repeating pattern of different longitudinal shapes to a continuous beam “on the fly” during the roll-forming process. A sweep station of the apparatus includes a primary bending roller tangentially engaging the continuous beam along the line level and an armature for biasing the continuous beam against the primary bending roller for a distance partially around a downstream side of the primary bending roller to form a sweep. Actuators adjustably move the armature partially around the downstream side of the primary bending roller between multiple positions for imparting a series of different longitudinal shapes. Internal and external mandrels control wall stability to allow even sharper sweeps. In one form, the apparatus also includes a coordinated cut-off, so that when separated into bumper beam segments, the ends of the individual beam segments have a greater sweep than their center sections.
Type:
Grant
Filed:
March 21, 2007
Date of Patent:
February 8, 2011
Assignee:
Shape Corp.
Inventors:
Bruce W. Lyons, Bryan E. Gould, James H. Dodd, Richard D. Heinz
Abstract: Circuits for correcting base line shift of the detector coupling circuit of a TOFMS provide gain and impedance characteristics that compensate for the AC coupling effect of the detector. In one circuit, base line correction is achieved by injecting a current equal to that which flows due to the buildup charge in the detectors AC coupling network. In another circuit, the current source drives an integrator which is coupled to the signal path to reduce the detector AC coupling effects. In another circuit, a low noise amplifier utilizes a feedback network that reduces the detector AC coupling effects. In yet another circuit, an operational amplifier is employed to reduce the detector AC coupling effects.
Abstract: The IT and FT values for coal and coke samples can be accurately predicted by applying equations to determine ST and HT temperatures. For reducing atmospheres, the equations are IT=C1×ST?C2×HT+C3 and FT=C4×HT?C5×ST+C6. For oxidizing atmospheres, the equations are IT=C7×ST?C8×HT+C9 and FT=C10×HT?C11×ST+C12. IT is the initial deformation temperature. ST is the softening temperature. HT is the hemispherical temperature. FT is the fluid temperature. C1-C12 are constants determined by multi-linear regression coefficient analytical techniques on a collection of data.
Abstract: A vehicle bed assembly includes a vehicle bed having a floor and first and second side walls, wherein the first and second side walls include a top portion with a cavity. At least one compartment is disposed below the floor of the vehicle bed. First and second rails are extendably received in the cavity of each of the first and second side walls, wherein the first and second rails are mounted in vertical tracks that provide for linear translation of the first and second rails between an extended position and a retracted position.
Abstract: A method of removing paint from a plastic substrate at least partially coated with a paint coating by: providing at least one plastic substrate at least partially coated with a paint coating; providing a kit for a user to utilize to remove paint from the plastic substrate, which is at least partially coated with a paint coating; immersing the at least partially coated plastic substrate into first mix of components by the end user wherein the first mix of components further comprises water when the at least partially coated plastic substrates are immersed into the first mix of components; and rinsing the plastic substrate with water. The immersing and rinsing steps remove the paint coating from the plastic substrate.
Abstract: A device and related method for counting objects, such as eggs or the like includes a plurality of first detectors, each of which has a locally delimited detection area, which can detect electromagnetic radiation, in particular light in the visible or infrared range, from the detection area, and which are arranged next to one another in a first line. An evaluation unit is coupled to the first detectors and is designed or configured to process the signals of the detectors and on the basis of the signals, to establish the presence of an object in the detection area.
Abstract: The fifth wheel hitch lube plate of the present invention comprises a perforated support member having a plurality of perforations and a lubricious material molded around the perforated support member such that the lubricious material covers both the top and bottom surfaces of the perforated support member and extends through the perforations formed in the perforated support member. Preferably, the support member is a perforated metal plate and the lubricious material is nylon, graphite, or an ultra-high molecular weight (UHMW) polyethylene material. The problems associated with utilizing nylon (or similar materials) and bonding it to a support plate are overcome by forming the plurality of apertures in the support plate so that a mechanical cohesive bond is formed between the upper and lower surfaces of the support plate, thereby substantially increasing the lube plate strength, and shear strength, while decreasing the likelihood that the lube plate may buckle.
Abstract: A method of exercising includes steps of providing a rod and weights configured for self-attachment to the rod, assembling at least one weight onto each end of the rod, and securing the weights to the ends by rotating the weights on the rod from a first rotational orientation to an interlocking second rotational orientation. The weights have a hub defining a hole, an undulating outer surface for gripping, and inwardly-extending curved fingers with a slot around the fingers allowing the fingers to flex for frictionally engaging the rod when the weights are rotated on the rod.