Patents Represented by Attorney R. A. McDonald

Find this attorney in the Justia Lawyer Directory

  • Synthesis for the preparation of 4-amino-4,5-dihydro-2-furancarboxylic acid
    Patent number: 4824974
    Abstract: This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C.sub.1-6 lower alkyl esters thereof. These compounds are .gamma.-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.
    Type: Grant
    Filed: October 15, 1987
    Date of Patent: April 25, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Joseph P. Burkhart, Gene W. Holbert
  • 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants
    Patent number: 4775688
    Abstract: This invention relates to novel 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones, to the intermediates and processes for their preparation, and to their use as antidepressants.
    Type: Grant
    Filed: May 15, 1987
    Date of Patent: October 4, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 5-(naphthyl)-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants
    Patent number: 4775689
    Abstract: This invention relates to novel 5-(naphthyl)-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and to their use as antidepressants.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: October 4, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 5-(Substituted benzyl)-6-oxo-2-piperazine carboxylic acids and esters
    Patent number: 4435571
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein R' is hydrogen, straight or branched chain lower alkyl having from 1 to 4 carbon atoms or benzyl, Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms, Y is hydrogen or a nitrogen blocking group selected from the group consisting of tertiary alkoxycarbonyl, benzyloxycarbonyl, cycloalkoxycarbonyl and vinyloxycarbonyl, R.sub.c is hydrogen, halogen or benzyloxy and R.sub.d is hydrogen, or R.sub.c and R.sub.d are benzyloxy; or an individual diastereomer thereof. Said compounds having use as intermediates in the production of enkephalin derivatives which in turn are used as analgesic and antipsychotic agents.
    Type: Grant
    Filed: July 19, 1982
    Date of Patent: March 6, 1984
    Assignee: Richardson Merrell Inc.
    Inventors: Albert A. Carr, Robert A. Farr, John M. Kane
  • Trityl picolinic acid derivatives and their use as anti-acne agents
    Patent number: 4044140
    Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
    Type: Grant
    Filed: November 28, 1975
    Date of Patent: August 23, 1977
    Assignee: Schering Corporation
    Inventor: Margaret H. Sherlock