Patents Represented by Attorney R. E. Carnahan
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Patent number: 4072670Abstract: Soy protein isolate having a greatly reduced content of phytic acid and phytate complexes and high nutritional quality is prepared by aqueous extraction of defatted soy flakes at a pH in excess of the isoelectric value of the protein, basification of the extract to a pH in excess of pH 10.5, and removal of insolubles. The soy protein is then precipitated from the clarified extract by acidification within the isoelectric range.Type: GrantFiled: October 26, 1976Date of Patent: February 7, 1978Assignee: Mead Johnson & CompanyInventors: Kenneth C. Goodnight, Jr., Grant H. Hartman, Jr., Robert F. Marquardt
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Patent number: 4067904Abstract: A new class of phenoxypropanolamine alkylsulfonyl derivatives and methods for their preparation are described. The new compounds possess antiarrhythmic and/or cardioselective .beta.-adrenergic blocking properties and are useful in the treatment of hypertension. Representative embodiments of the invention are 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol and 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(1-phenoxy-2-propylamino)-2-propanol, the latter compound is particularly outstanding as an antihypertensive.Type: GrantFiled: September 10, 1976Date of Patent: January 10, 1978Assignee: Mead Johnson & CompanyInventors: William T. Comer, William E. Kreighbaum
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Patent number: 4055658Abstract: Preparation of cyanomethylphenethanolamines useful as adrenergic stimulants is described. Preferred compounds such as 2-hydroxy-5-[1-hydroxy-2-[(1,1-dimethyl-2-phenylethyl)amino]ethyl]-benzene acetonitrile are selective beta-adrenergic stimulants having relatively greater potency on respiratory smooth muscle than on cardiac muscle. Such compounds are particularly valuable in the treatment of bronchial conditions.Type: GrantFiled: May 17, 1976Date of Patent: October 25, 1977Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William L. Matier, Herbert R. Roth
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Patent number: 4054656Abstract: 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammmals are N-[3(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxyl ate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.Type: GrantFiled: September 10, 1975Date of Patent: October 18, 1977Assignee: Mead Johnson & CompanyInventor: Davis L. Temple, Jr.
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Patent number: 4052455Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.Type: GrantFiled: August 4, 1975Date of Patent: October 4, 1977Assignee: Mead Johnson & CompanyInventors: William L. Matier, William T. Comer
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Patent number: 4046874Abstract: A unique shaving cream containing no soap, fat or oil which functions without pre-wetting the skin is formed from an aqueous foam containing 0.5 to 7.5% by weight of a polyglycerol ester and from 2 to 10% by weight of a water insoluble pulverulent bodying agent to provide the desired texture.Type: GrantFiled: November 17, 1975Date of Patent: September 6, 1977Assignee: Mead Johnson & CompanyInventors: John Lester Gabby, Dennis Dale Corbin, Jack Bruner Lowe
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Patent number: 4046891Abstract: Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.Type: GrantFiled: March 26, 1976Date of Patent: September 6, 1977Assignee: Mead Johnson & CompanyInventors: Yao Hua Wu, Walter G. Lobeck, Jr.
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Patent number: 4039696Abstract: A process is described by means of which whole soybeans are converted into a milk-like product which is bland in flavor, has functionality characteristics similar to cow's milk, and which has a substantially reduced proportion of soybean carbohydrate. The process involves a combination of blanching, wet grinding, homogenizing, centrifuging, and heat treating steps.Type: GrantFiled: April 2, 1976Date of Patent: August 2, 1977Assignee: Mead Johnson & CompanyInventors: Robert F. Marquardt, Grant H. Hartman, Jr., Kenneth C. Goodnight, Jr.
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Patent number: 4038145Abstract: The mixed lymphocyte reaction in tissue culture is used to detect the tumor induced autoimmune reaction which has been found to be characteristic of lymphoid malignancies. Lymphocytes from blood, spleen, and lymph nodes are employed in combinations of two. A mixed lymphocyte reaction from any one of the three possible combinations is indicative of the presence of a lymphoid malignancy.Type: GrantFiled: July 8, 1974Date of Patent: July 26, 1977Assignee: Mead Johnson & CompanyInventor: Richard G. Devlin
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Patent number: 4021562Abstract: A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]-oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxide is a representative embodiment of the invention.Type: GrantFiled: December 8, 1975Date of Patent: May 3, 1977Assignee: Mead Johnson & CompanyInventors: John E. Lawson, Ronald D. Dennis
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Patent number: 4006240Abstract: A biochemical explanation for preferential alcohol consumption is proposed involving excessive cholinergic activity in brain tissue. A process by which alcohol aversion can be induced involving treatment with a choline acetylase inhibitor is provided.Type: GrantFiled: March 19, 1975Date of Patent: February 1, 1977Inventors: Andrew K. S. Ho, Benjamin Kissin
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Patent number: 4005222Abstract: A mucolytic process is disclosed which comprises contacting N-(2-hydroxyethyl)mercaptoacetamidobenzamides or mercaptoacylamidobenzoic acids, mercaptoacetylsulfanilic acids and alkanoylthio derivatives thereof with mucus. Illustrative of compounds useful in the mucolytic process of the present invention are 4-(2-mercaptoacetamido)benzoic acid and N-(2-mercaptoacetyl)sulfanilic acid.Type: GrantFiled: May 21, 1975Date of Patent: January 25, 1977Assignee: Mead Johnson & CompanyInventors: Tellis Alexander Martin, William Timmey Comer
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Patent number: 4001229Abstract: Triphenylethylenes having an N-(dialkylaminoalkyl)alkanesulfonamide substituent in the one of the phenyl rings may be prepared from similarly substituted benzophenones by reaction thereof with a benzyl Grignard reagent followed by dehydration of the resulting triphenylethanol intermediate and if desired chlorination or nitration of the resulting product. The triphenylethylenes have estrogenic and post-coital antifertility action and are useful as intermediates for the preparation of other triphenylethylene compounds.Type: GrantFiled: April 4, 1974Date of Patent: January 4, 1977Assignee: Mead Johnson & CompanyInventor: William E. Kreighbaum
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Patent number: 4000304Abstract: 2-(2- or 3-Indolyl)indolines, unsubstituted and carbon substituted, condense with N-mono substituted carboxamides or with lactams under the influence of phosphorus oxychloride to produce 1-(N-substituted iminoalkyl)-2-(2- or 3-indolyl)indolines. The 2-(3-indolyl)-1-[2-(1-pyrrolinyl)]indolines rearrange to produce benzodiazepine derivatives. These products have diuretic, antituromobogenic, and antiarrhythmic activity on oral administration.Type: GrantFiled: March 24, 1975Date of Patent: December 28, 1976Assignee: Mead Johnson & CompanyInventors: Yao Hua Wu, Arthur Jacob Mueller
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Patent number: 3993776Abstract: 2'-Hydroxy-5'-[1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl]methanesu lfonanilide is a potent anorexigenic agent and orally active bronchodilator.Type: GrantFiled: October 21, 1975Date of Patent: November 23, 1976Assignee: Mead Johnson & CompanyInventors: William T. Comer, Herbert R. Roth
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Patent number: 3990597Abstract: The present invention provides a container with a removable adapter cap for use in nasogastric tube feeding. The adapter cap and container include cooperating elements which provide vent means to secure steady flow during delivery of the liquid dietary contents of the container.Type: GrantFiled: September 9, 1975Date of Patent: November 9, 1976Assignee: Mead Johnson & CompanyInventor: Raymond W. Barton
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Patent number: 3985897Abstract: Dextrorotatory stereoisomers of beta-adrenergic stimulatory phenethanolamines such as isoproterenol, soterenol, salbutamol, carbuterol, terbutaline, and metaproterenol lower normal or elevated intraocular pressure when topically administered to the eye. Reduction in intraocular pressure is of particular importance in the treatment of glaucoma, a disease marked by ocular hypertension. The dextrorotatory phenethanolamine compounds employed in the process of the present invention are notable for the low order of adrenergic activity in contrast to levorotatory and racemic stereoisomeric forms which are very potent beta-adrenergic stimulatory agents. Consequently, those side effects generally associated with adrenergic activation such as tachycardia, mydriasis, hypertension and hypotension are absent.Type: GrantFiled: November 14, 1974Date of Patent: October 12, 1976Assignee: Mead Johnson & CompanyInventors: Richard J. Seidehamel, Kendrick W. Dungan
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Patent number: 3976776Abstract: The present invention concerns the class of heterocyclic carbon compounds comprised of N-(heteroarcyclic)piperazinylalkyl derivatives of azaspiroalkanediones which have potent and specific tranquilizing action and anti-emetic properties. Typical embodiments of this invention are 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dio ne and 8-[4-[4-(2-pyridyl)-1-piperazinyl]-butyl]-8-azaspiro[4.5]decane-7,9-dione.Type: GrantFiled: July 14, 1975Date of Patent: August 24, 1976Assignee: Mead Johnson & CompanyInventors: Yao Hua Wu, James W. Rayburn
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Patent number: 3946004Abstract: Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]-pheno thiazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.Type: GrantFiled: November 6, 1974Date of Patent: March 23, 1976Assignee: Mead Johnson & CompanyInventors: Yao Hua Wu, Walter G. Lobeck, Jr.
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Patent number: RE29359Abstract: .Iadd.Palatable liquid pharmaceutical compositions containing theophylline and guaiacol or other water soluble form thereof such as glyceryl guaiacolate. The latter have a solubilizing effect on theophylline making possible concentrations of theophylline in solution in excess of the saturated solution value in the absence of said solubilizing agents. .Iaddend.Type: GrantFiled: July 28, 1976Date of Patent: August 16, 1977Assignee: Mead Johnson & CompanyInventors: Neil H. Mercer, Robert J. Bequette