Patents Represented by Attorney R. G. Jackson
-
Patent number: 4680325Abstract: Isocyanurate esters of thioalkanoamidophenols useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by reacting an appropriate isocyanurate trithiol, which is a selected tris-mercapto alkanoic acid ester of tris-(2-hydroxyethyl) isocyanurate with an appropriate alkenyl compound, which is a selected N-alkenyl[4-amino-(mono- or dialkyl)phenol] or, where the alkano moiety is a sole methylene group, by reaction of tris-(2-hydroxyethyl) isocyanurate with an appropriate [mercapto-N-(mono- or di-alkyl]-4-hydroxyphenylalkanamide alkenoic] acid. In a preferred embodiment, the ester is 1,3,5-tris{2-hydroxy ethyl-[3-mercapto-(3',5'-di-tert-butyl-4'-hydroxypropionanilide)]propionat e}isocyanurate.Type: GrantFiled: February 10, 1986Date of Patent: July 14, 1987Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi, Henry J. Buehler
-
Patent number: 4663480Abstract: Disclosed is a process for inhibiting polymerization of polymerizable ethylenically unsaturated monomers such as hydrocarbons, acids and esters, wherein manganese nitrite, i.e. Mn(NO.sub.2).sub.2, is employed as an inhibitor. A composition including a polymerizable ethylenically unsaturated monomer and Mn(NO.sub.2).sub.2 is also disclosed. In two preferred embodiments, acrylic acid and styrene, respectively, are the monomers.Type: GrantFiled: June 5, 1985Date of Patent: May 5, 1987Assignee: Mallinckrodt, Inc.Inventors: Ervin B. Inskip, Douglas C. Caskey, William E. Dummitt
-
Patent number: 4654299Abstract: A procedure for the immobilization of proteins on polystyrene surfaces which includes a pre-treatment of the polystyrene surface with a bis-diazonium compound of the general formula I where ##STR1## R1 stands for a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or a nitro group and whereR2 stands for a hydrogen atom, a halogen atom or an alkyl group and where X stands for an anion and the subsequent adsorption of the protein on the surface pretreated.Proteins immobilized by its procedure may be used in immunoassays.Type: GrantFiled: March 21, 1984Date of Patent: March 31, 1987Assignee: Mallinckrodt Diagnostica (Germany) GmbHInventor: Dierck Lentfer
-
Patent number: 4642399Abstract: A method is disclosed for producing fluoronitrobenzene compounds by reacting chloronitrobenzene compounds with a fluoride salt in the presence of a tetramethylammonium salt phase-transfer catalyst. This catalyst allows the use of elevated reaction temperatures with substantial freedom from catalyst inactivation, resulting in yields and reaction rates which are improved over those of previously known methods using higher molecular weight quaternary ammonium salt phase transfer catalysts having more total carbon atoms in their ammonium cations.Type: GrantFiled: November 29, 1984Date of Patent: February 10, 1987Assignee: Mallinckrodt, Inc.Inventor: Carl R. White
-
Patent number: 4642398Abstract: An improved process is disclosed for preparing fluoronitrobenzene compounds wherein chloronitrobenzene compounds are reacted with potassium fluoride in a solvent dispersion thereof prepared from a mixture including the solvent, the fluoride, methanol and an aromatic compound.Type: GrantFiled: January 6, 1986Date of Patent: February 10, 1987Assignee: Mallinckrodt, Inc.Inventor: Gary L. Cantrell
-
Patent number: 4639520Abstract: N-ethoxycarbonyl-14-hydroxynorcodeinone is prepared by contacting N-ethoxycarbonyl-norcodeinone enol acetate with an aromatic or aliphatic mono-basic or poly-basic peroxy-acid under reaction conditions effective for substituting an --OH group in the 14-position of the norcodeinone enol acetate.In a preferred embodiment the reaction conditions include effecting the contacting in the presence of (A) a moderately strong acid having a pK.sub.a of from about 0.3 to about 3.5, (B) an inert organic solvent, and (C) in the substantial absence of water.Codeine is converted to noroxymorphone by an improved process employing the above method for introducing the 14-hydroxy group into the codeine derivative.Type: GrantFiled: March 27, 1984Date of Patent: January 27, 1987Assignee: Mallinckrodt, Inc.Inventor: Frank Kavka
-
Patent number: 4638079Abstract: Disclosed is a process for inhibiting polymerization of polymerizable ethylenically unsaturated monomers such as hydrocarbons, acids and esters, wherein a cobalt (III), nickel (II) or manganese (II) complex of N-nitrosophenylhydroxylamine is employed. A composition including a polymerizable ethylenically unsaturated monomer and the complex is also disclosed. In a preferred embodiment, polymerization of an acrylic acid or an acrylate ester is inhibited.Type: GrantFiled: January 17, 1985Date of Patent: January 20, 1987Assignee: Mallinckrodt, Inc.Inventors: Ervin B. Inskip, Joseph M. Patane
-
Patent number: 4634728Abstract: Polyol carboxyalkylthioalkanoamidophenol compounds useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by (A) reaction of an appropriate polythiol, which is a selected tetra-(mercapto alkanoic acid) ester of pentaerythritol or a selected tri-(mercapto alkanoic acid) ester of a selected 1,1,1-trimethylolalkane, with an appropriate alkenyl compound, which is a selected N-alkenoyl[4-amino(mono- or dialkyl)phenol] or (B), where the alkanol moiety is a sole methylene group, by reaction of pentaerythritol or an appropriate 1,1,1-trimethylolalkane with an appropriate mercapto-N(mono- or di-alkyl-4-hydroxyphenylalkamide) alkanoic acid. In a preferred embodiment, the compound is pentaerythritol tetrakis[3-mercapto-N-(3',5'-di-ti-butyl-4'-hydroxyphenyl propanamide) propionate].Type: GrantFiled: August 20, 1985Date of Patent: January 6, 1987Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi, Henry J. Buehler
-
Patent number: 4631284Abstract: Disclosed are an acetaminophen composition containing a minor amount of a pheniramine maleate, a spray-drying method for preparing the composition and orally administerable analgesic antihistaminic tablets formed from the composition.Type: GrantFiled: July 16, 1985Date of Patent: December 23, 1986Assignee: Mallinckrodt, Inc.Inventors: Anil M. Salpekar, John Johnson
-
Patent number: 4600579Abstract: An N-acetyl-p-aminophenol composition capable of being directly formed into a tablet having high hardness, short disintegration time and short dissolution time is disclosed. The composition includes N-acetyl-p-aminophenol, a pharmaceutically acceptable partially gelatinized starch, a pharmaceutically acceptable lubricant, water and optionally an auxiliary binder, an auxiliary disintegrant or both of these optional components. Also disclosed is a method for preparing the essential components (and optional components if desired) and spray drying the slurry.Type: GrantFiled: June 7, 1983Date of Patent: July 15, 1986Assignee: Mallinckrodt, Inc.Inventors: Anil M. Salpekar, Steven R. Freebersyser, Douglas A. Robinson
-
Patent number: 4551551Abstract: Bis(aminophenyl) ethers are prepared by effecting condensation reaction of an (N-acetyl)aminophenol or the corresponding sodium or potassium (N-acetyl)aminophenate with a halonitrobenzene under condensation reaction conditions to form an (N-acetyl)aminophenylnitrophenyl ether and hydrogenating the nitro group thereof under nitro- group hydrogenation conditions to form an (N-acetyl)bis(aminophenyl) ether. The latter compound is hydrolyzed with aqueous mineral acid under acid hydrolysis conditions to form an acidic aqueous dispersion of the bis(aminophenyl) ether product, which can readily be recovered from the disperson. Final bis(aminophenyl) ether products thus prepared are typically of high purity and excellent color properties, i.e., substantially colorless.Type: GrantFiled: September 27, 1982Date of Patent: November 5, 1985Assignee: Mallinckrodt, Inc.Inventor: Ervin B. Inskip
-
Patent number: 4539428Abstract: Diaminodiphenyl ethers (DADPE's) are prepared by refluxing sodium or potassium aminophenate with chloronitrobenzene in dimethylformamide. The reaction mixture is hydrogenated directly without isolating the resulting intermediate product, aminophenyl-nitrophenyl ether, to form the corresponding DADPE, e.g., oxydianiline (ODA). The DADPE is crystallized from the hydrogenated reaction mixture in the presence of an aliphatic alcohol, which may be added to the reaction mixture prior to, during, or after hydrogenation. The resulting crystallized DADPE is typically of high purity and excellent color.Type: GrantFiled: May 10, 1982Date of Patent: September 3, 1985Assignee: Mallinckrodt, Inc.Inventors: Philip H. Merrell, Michael F. Ellis
-
Patent number: 4501920Abstract: A salt of 3,4,5-trimethoxybenzoic acid is prepared by initially reacting hydrolyzable tannin with a methylation agent in an alkaline medium under methylation conditions to form methylated tannin and thereafter hydrolyzing the methylated tannin by reaction thereof with a hydrolysis agent under alkaline hydrolysis conditions. The resulting salt can be neutralized to form 3,4,5-trimethoxybenzoic acid, which can readily be recovered.Type: GrantFiled: September 29, 1982Date of Patent: February 26, 1985Assignee: Mallinckrodt, Inc.Inventor: Muthunadar P. Periasamy
-
Patent number: 4098800Abstract: Disclosed is a process for preparing oligomeric polyetheramide-acid by reacting an aromatic dianhydride component including an aromatic bis(ether anhydride) with an organic diamine in an inert organic liquid selected from methylene chloride, chloroform, 1,2-dichloroethane, and mixtures thereof with acetone. The oligomeric polyetheramide-acid is substantially insoluble in the inert organic liquid, in which the oligomer typically appears as a precipitate which may be recovered in powder or finely divided particulate form without need for grinding.Type: GrantFiled: April 18, 1977Date of Patent: July 4, 1978Assignee: General Electric CompanyInventors: Eugene G. Banucci, Martin A. Byrne