Patents Represented by Attorney R. H. Uloth
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Patent number: 4282265Abstract: Vegetable oil mixtures are prepared containing from 20-50% by weight of palm oil and quantities of lauric acid oils, oleic acid oils, and linoleic acid oils needed to provide proportions of oleic, palmitic, and linoleic triglycerides similar to proportions in human milk. The mixtures are readily absorbed by normal full-term infants and are well suited as fat ingredients for infant formulas.Type: GrantFiled: January 14, 1980Date of Patent: August 4, 1981Assignee: Bristol-Myers CompanyInventor: Richard C. Theuer
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Patent number: 4258027Abstract: The invention disclosed provides a multi-fractionable tablet structure initially configurated in a unitary dosage while having readily severable sub-dosage units as components thereof. Score markings are positioned variously about the tablet such as along the top and bottom surfaces thereof. Additionally, score markings may appear along opposite vertical side surfaces of the tablet. Special placement of the score markings readily permits alternatively an accurate equal bisectional or trisectional fracture of the tablet as may be desired for patient consumption.Type: GrantFiled: February 14, 1980Date of Patent: March 24, 1981Assignee: Mead Johnson & CompanyInventors: Michael K. Ullman, Stephen T. David, Claude E. Gallian
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Patent number: 4254124Abstract: 2-[3-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]propyl]-1,2,4-triazolo[4, 3-a]pyridin-3(2H)-one and its pharmaceutically acceptable acid addition salts are antidepressant agents.Type: GrantFiled: September 24, 1979Date of Patent: March 3, 1981Assignee: Mead Johnson & CompanyInventor: Duane F. Morrow
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Patent number: 4252815Abstract: 1-Secondary-amino-3-(1-phenyl and substituted phenyl-5-tetrazolyloxy)-2-propanols are new compounds which are useful as cardiovascular agents having vasodilator, antiarrhythmic and .beta.-adrenergic blocking actions.Type: GrantFiled: August 15, 1979Date of Patent: February 24, 1981Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William T. Comer
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Patent number: 4252806Abstract: 2-[3-[4-Arylpiperazin-1-yl]propyl]-1,2,4-triazolo[4,3-a]-quinolin-3(2H)-one s are antidepressant agents.Type: GrantFiled: September 24, 1979Date of Patent: February 24, 1981Assignee: Mead Johnson & CompanyInventor: Duane F. Morrow
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Patent number: 4223031Abstract: 6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxy-methylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.Type: GrantFiled: May 5, 1978Date of Patent: September 16, 1980Assignee: Mead Johnson & CompanyInventors: Robert R. Covington, Davis L. Temple, Jr., Joseph P. Yevich
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Patent number: 4215104Abstract: The invention disclosed provides a multi-fractionable tablet structure initially configurated in a unitary dosage while having readily severable sub-dosage units as components thereof. Score markings are positioned variously about the tablet both along the top and bottom surfaces of an approximately rectangular configuration whereas in preferred embodiments thereof, score markings additionally appear along opposite vertical side surfaces of the tablet. Special placement of the score markings readily permit at least either an accurate bisectional fracture or accurate trisectional fracture of the tablet as may be desired for patient consumption.Type: GrantFiled: March 26, 1979Date of Patent: July 29, 1980Assignee: Mead Johnson & CompanyInventors: Michael K. Ullman, Stephen T. David, Claude E. Gallian
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Patent number: 4186131Abstract: 1-Secondary-amino-3-(1-phenyl and substituted phenyl-5-tetrazolyloxy)-2-propanols are new compounds which are useful as cardiovascular agents having antiarrhythmic and .beta.-adrenergic blocking actions.Type: GrantFiled: March 24, 1978Date of Patent: January 29, 1980Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William T. Comer
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Patent number: 4182763Abstract: Buspirone hydrochloride is an effective anti-anxiety agent for the palliative treatment of neurotic patients in which symptoms of anxiety are predominant at doses which are without observable effect in either normal individuals or psychotic patients.Type: GrantFiled: May 22, 1978Date of Patent: January 8, 1980Assignee: Mead Johnson & CompanyInventors: George P. Casten, Gordon R. McKinney, Roger E. Newton, E. Crosby Tompkins, John H. Weikel, Jr.
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Patent number: 4160863Abstract: A novel crystalline monohydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-methyl-3-caphem-4 -carboxylic acid is prepared and found to be a stable useful form of the cephalosporin antibiotic especially advantageous for pharmaceutical formulations.Type: GrantFiled: February 2, 1978Date of Patent: July 10, 1979Assignee: Bristol-Myers CompanyInventors: Daniel Bouzard, Abraham Weber, Jacques Stemer
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Patent number: 4159377Abstract: 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4-oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.Type: GrantFiled: August 22, 1977Date of Patent: June 26, 1979Assignee: Mead Johnson & CompanyInventor: Davis L. Temple, Jr.
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Patent number: 4140756Abstract: A tablet for controlled release of a water soluble medicament or dietary supplement is comprised of a water insoluble wax-like matrix core containing the water soluble medicament and coated with a permeable erosion resistant polymeric film. The core constitutes 95% or more of the tablet weight.Type: GrantFiled: October 18, 1977Date of Patent: February 20, 1979Assignee: Mead Johnson & CompanyInventor: Claude E. Gallian
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Patent number: 4091120Abstract: Superior soy protein beverages are prepared by formulation of carbohydrate, fat, or other nutritional ingredients with the liquid retentate of a soy protein ultrafiltration purification process without first recovering the soy protein by precipitation or drying of the retentate. Short-time high-temperature heat treatment of soy protein solution purified by ultrafiltration improves functional and nutritional qualities thereof.Type: GrantFiled: November 15, 1976Date of Patent: May 23, 1978Assignee: Mead Johnson & CompanyInventors: Kenneth C. Goodnight, Jr., Grant H. Hartman, Jr., Robert F. Marquardt
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Patent number: 4088795Abstract: An oilseed lipid-protein product adapted for food use is prepared by aqueous extraction of fat containing oilseed materials including the ground raw oilseed or full-fat oilseed flour or flake at a pH in excess of the isoelectric range of the protein for the purpose of solubilizing the protein. Insoluble material is removed by centrifugation or filtration, and soluble carbohydrate is removed from the resulting lipid-protein emulsion by membrane filtration.Type: GrantFiled: November 19, 1976Date of Patent: May 9, 1978Assignee: Mead Johnson & CompanyInventors: Kenneth C. Goodnight, Jr., Grant H. Hartman, Jr.
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Patent number: 4075344Abstract: New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action. Representative embodiments of this invention are 6,7-dimethoxy-2-methyl-1-veratryl-3(2H)-isoquinolone hydrochloride, 2-allyl-6,7-dimethoxy-2-veratryl-3(2H)-isoquinolone hydrochloride, 2-cyclopropyl-6,7-dimethoxy-1-3(2H)-isoquinolone hydrochloride, 2-amino-6,7-dimethoxy-1-veratryl-3(2H)-isoquinolone hydrochloride and 3-ethoxy-6,7-dimethoxy-1-veratrylisoquinoline.Type: GrantFiled: December 22, 1976Date of Patent: February 21, 1978Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William T. Comer
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Patent number: 4072670Abstract: Soy protein isolate having a greatly reduced content of phytic acid and phytate complexes and high nutritional quality is prepared by aqueous extraction of defatted soy flakes at a pH in excess of the isoelectric value of the protein, basification of the extract to a pH in excess of pH 10.5, and removal of insolubles. The soy protein is then precipitated from the clarified extract by acidification within the isoelectric range.Type: GrantFiled: October 26, 1976Date of Patent: February 7, 1978Assignee: Mead Johnson & CompanyInventors: Kenneth C. Goodnight, Jr., Grant H. Hartman, Jr., Robert F. Marquardt
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Patent number: 4067904Abstract: A new class of phenoxypropanolamine alkylsulfonyl derivatives and methods for their preparation are described. The new compounds possess antiarrhythmic and/or cardioselective .beta.-adrenergic blocking properties and are useful in the treatment of hypertension. Representative embodiments of the invention are 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol and 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(1-phenoxy-2-propylamino)-2-propanol, the latter compound is particularly outstanding as an antihypertensive.Type: GrantFiled: September 10, 1976Date of Patent: January 10, 1978Assignee: Mead Johnson & CompanyInventors: William T. Comer, William E. Kreighbaum
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Patent number: 4058531Abstract: N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.Type: GrantFiled: March 23, 1976Date of Patent: November 15, 1977Assignee: Bristol-Myers CompanyInventors: Ivo Monkovic, Carol Bachand, Henry Wong
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Patent number: 4055658Abstract: Preparation of cyanomethylphenethanolamines useful as adrenergic stimulants is described. Preferred compounds such as 2-hydroxy-5-[1-hydroxy-2-[(1,1-dimethyl-2-phenylethyl)amino]ethyl]-benzene acetonitrile are selective beta-adrenergic stimulants having relatively greater potency on respiratory smooth muscle than on cardiac muscle. Such compounds are particularly valuable in the treatment of bronchial conditions.Type: GrantFiled: May 17, 1976Date of Patent: October 25, 1977Assignee: Mead Johnson & CompanyInventors: William E. Kreighbaum, William L. Matier, Herbert R. Roth
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Patent number: 4054656Abstract: 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammmals are N-[3(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxyl ate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.Type: GrantFiled: September 10, 1975Date of Patent: October 18, 1977Assignee: Mead Johnson & CompanyInventor: Davis L. Temple, Jr.