Abstract: Air is separated in a vessel housing gas separation membranes. A flow control valve controls the passage of air to an inlet header of the vessel. The setting of the valve is adjusted in accordance with the level of oxygen impurity in product nitrogen leaving the vessel for an outlet header. A second flow control valve is provided and is of a kind whereby product nitrogen is able to be delivered at a constant flow rate over a range of different pressures upstream thereof. Accordingly, the apparatus is able to deliver nitrogen at a desired purity and flow rate.

Abstract: This invention pertains to novel substituted pyrazolyl compounds useful as intravenous anesthetics represented by the Formula: ##STR1## including geometric and optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:one of Y and Z is nitrogen, and the other is CH;R.sub.1 is hydrogen or lower-alkyl;R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, --CHO, lower-alkylcarbonyl, lower-alkoxy carbonyl, lower-alkylaminocarbonyl, lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkenyl, lower-alkylcarbonyloxymethyl, substituted and unsubstituted heterocyclic rings, and substituted or unsubstituted aryl groups, wherein the symbol * represents a carbon atom which may be asymmetric and at least one of R.sub.2 and R.sub.3 is other than hydrogen.

Abstract: This invention pertains to polypeptides having gastrointestinal motor inhibitory activity represented by the formula: ##STR1## including optically active isomeric forms and the pharmaceutically acceptable acid addition salts thereof wherein A is the L-stereoisomer of a lipophilic aliphatic or alicyclic amino acid; B is selected from the group consisting of L and D aromatic, heteroaromatic, lipophilic aliphatic, and alicyclic amino acids; D is the L-stereoisomer of a lipophilic aliphatic or alicyclic amino acid; E is the L-stereoisomer of an aromatic, aliphatic, or alicyclic amino acid; F is the L-stereoisomer of an aromatic or heteroaromatic amino acid; G is glycine or D-alanine; H is L-glutamic acid or L-glutamine; I is L-glutamine, L-glutamic acid, or L-alanine; J is a direct bond between I and group --NH-- or is selected from the group consisting of Z, Z-Leu, Z-Leu-Gln, Z-Leu-Gln-Glu (SEQ ID NO:2), Z-Leu-Gln-Glu-Lys (SEQ ID NO:3), Zleu-Gln-Glu-Lys-Glu (SEQ ID NO:4), Z-Leu-Gln-Glu-Lys-Glu-Arg (SEQ ID NO:5),

Abstract: An apparatus for dispensing a cryogenic liquid includes means for focusing a beam of energy, eg. laser energy from a source onto the liquid cryogen as it passes through an outlet from a cryogenic liquid container.

Abstract: A cooling apparatus comprises a cooling chamber (2), means (4) for introducing liquefied gas or its cold vapor thereinto, an exhaust passage (16) having flow inducing means associated therewith and a heat transfer means (46) associated with said exhaust passage (16) in which the heat transfer means operates to transfer heat from a heat source to the exhaust gas.

Abstract: A method and apparatus for treating a freshly metallized substrate in which a metal substrate is passed through a bath of molten metal for the purpose of applying a coating thereto while a treating gas containing a reducing gas, a non-oxidizing gas or combination thereof is provided at the region where the metallized substrate exits the molten metal bath to thereby at least reduce oxidation of the metallized substrate and the surface of the molten metal bath.

Abstract: A fault current limiter for use in alternating current transmission utilizes a (high temperature) superconductor body. If the current density through the body exceeds a critical value, the superconductor becomes a resistor; the fault current limiter makes use of this principle. In order to enable the critical current density to be selected from within a range of different values, the superconductor is immersed in a volume of cryogenic liquid, e.g. liquid nitrogen, in a vessel provided with a closure having an outlet communicating with a duct in which is disposed a manually adjustable back pressure regulator. The back pressure regulator enables the pressure in the ullage space of the vessel to be set at a chosen value, usually below atmospheric pressure. The liquid nitrogen is stored in the vessel at its boiling point which depends on the pressure in the ullage space. Accordingly, the temperature of the liquid nitrogen can be set by the regulator.

Abstract: A method and apparatus (1) for the control of biological treatment of waste water in which waste water is fed to a substantially air tight supported growth biological filter unit (2) that includes an exhaust gas vent (5). Dissolved oxygen is supplied to the filter unit and the oxygen consumption rate across the filter is measured by comparing the flow rate of oxygen into the filter (2) to the flow rate of oxygen exiting the filter through the gas vent (5). The feed rate of waste water is adjusted to maintain a predetermined oxygen consumption, thereby controlling the effluent quality.

Abstract: An apparatus for freezing particulate bodies, comprising a rotary member having a generally horizontal freezing surface, means for dispensing said bodies onto said surface, means for cooling the surface to a freezing temperature and means for collecting said bodies in at least peripherally frozen state from said surface. The particulate bodies may comprise food stuffs, such as prawns or cream, a pharmaceutical, a microbiological culture, or a puree. Liquified carbon dioxide and nitrogen are preferred for cooling.

Abstract: Apparatus and process for cooling harvested edible and non-edible plants and plant products with a cryogenic fluid wherein the plants and plant products are delivered to an on-site freezer which receives the cryogenic fluid and the cooled plants and plant products and at least a portion of the cryogenic fluid is sent to a transportation vehicle.

Abstract: This invention pertains to polypeptides, other than motilin, having gastrointestinal motor stimulating activity and represented by the formula: ##STR1## wherein A and D are lipophilic aliphatic or alicyclic amino acids; B is L-proline or L-alanine; E is an aromatic, lipophilic aliphatic, or alicyclic amino acid; F is an aromatic or heteroaromatic amino acid; G is glycine or D-alanine; H is L-glutamic acid or L-glutamine; I is L-glutamine, L-glutamic acid, or L-alanine; J is a direct bond or is selected from, inter alia Z, Z-Leu, Z-Leu-Gln, Z-Leu-Gln-Glu (SEQ ID NO:2) or Z-Leu-Gln-Glu-Lys (SEQ ID NO:3), wherein Z is, inter alia, arginine, D-arginine, D-homoarginine, or D-lysine, and further wherein the amino acids represented by A, D, E and F are L-stereoisomers; R.sub.1 is lower-alkyl or allyl; R.sub.2 is hydrogen, lower-alkyl, propargyl, or allyl; R.sub.3 is hydrogen, lower-alkyl, and allyl; R.sub.

Abstract: An improved process for the production of isoflurane is disclosed. Isoflurane is formed by the exhaustive chlorination of 2,2,2-trifluoroethyl difluoromethyl ether with chlorine gas. The reaction mixture, preferably without purification or refining, is treated with UV light in the presence of isopropanol to reduce 1,1-dichloro-2,2,2-trifluoroethyl difluoromethyl ether, the other major component thereof, to isoflurane. Isoflurane is thereby obtained in yields of at least 80%.

Abstract: Polypeptides corresponding to mature human serum albumin residues 1 to n, where n is between 369 and 419 inclusive, are useful as substitutes for albumin in the treatment of burns and shock in humans, the clearance of undesirable compounds, (such as bilirubin) from human blood, in laboratory growth media and in HSA assays. The polypeptides may be produced by recombinant DNA techniques, especially in yeast.

Abstract: Secretory leader sequences, for use in secreting heterologous polypeptides in yeast, are formed by fusing part of the human serum albumin pre-sequence or part of the Kluyveromyces lactis killer toxin pre-sequence to the Saccharomyces cerevisiae mating factor alpha-1 KEX2 cleavage recognition site. The resulting fusion leader sequences are:(a) H.sub.2 N-Met-Lys-Trp-Val-Ser-Phe-Ile-Ser-Leu-Leu-Phe-Leu-Phe-Ser-Ser-Ala-Tyr-Ser- Arg-Ser-Leu-Asp-Lys-Arg-COOH or(b) H.sub.2 N-Met-Asn-Ile-Phe-Tyr-Ile-Phe-Leu-Phe-Leu-Leu-Ser-Phe-Val-Gln-Gly-Ser-Leu- Asp-Lys-Arg-COOHConservative variations are also encompassed.

Abstract: A feed gas stream containing at least 60% by volume of hydrogen sulphide is burnt in a first combustion region to form water vapor and sulphur dioxide. Oxygen is employed to support combustion is the region. Thermal reaction then takes place in a thermal reaction region between hydrogen sulphide and sulphur dioxide to form sulphur vapor and water vapor. The resulting gas mixture is then cooled and sulphur vapor is extracted in a condenser. The gas mixture then passes into a second combustion region in which a further portion of the hydrogen sulphide is burnt in the presence of oxygen to form further sulphur dioxide and to adjust the mole ratio of hydrogen sulphide to sulphur dioxide to about 2:1. Further reaction between hydrogen sulphide and sulphur dioxide may be conducted in a further thermal reaction region and in catalytic reactors with further sulphur extraction in further condensers.

Abstract: A process for the preparation of highly purified optical isomers of desflurane, i.e. 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, is described wherein the highly purified opposite optical isomer of iso-flurane is reacted with bromine trifluoride in the cold, preferably in the presence of a solvent. A preferred solvent is bromine. The highly purified positive isomer of desflurane is advantageous over the negative isomer or the racemate.

Abstract: The present invention is directed to a fiber optic sensor for analyzing pH which comprises (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric matrix in contact with the sensor, wherein the fluorescent dye is seminaphthorhodaflor-1-isothiocyanate, the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the dye is chemically bonded to the polymer.

Abstract: This invention pertains to a method for treating a condition of nausea and vomiting in a mammal which comprises administering a therapeutically effective amount of a 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinyl-6-carboxylic acid derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or lower-alkyl; R.sub.3 is selected from the group consisting of hydrogen, lower-alkyl, nitro, amino, cyano, and alkylmercapto; R.sub.4 and R.sub.5 are selected from the group consisting of hydrogen, lower-alkyl, aryl, and aryl lower-alkyl, or R.sub.4 and R.sub.5 together with the carbon atom to which they are attached form a 5- or 6-member saturated hydrocarbon ring; R.sub.6 is selected from the group consisting of hydrogen, lower-alkyl, aryl lower-alkyl, formyl, lower-alkyl carbonyl, and aryl carbonyl; R.sub.7 is selected from the group consisting of phenyl, thienyl, indolyl, indazolyl, benzo[b]furanyl, benzo[b]thiophenyl, and R.sub.8 R.sub.9 --N--; R.sub.

Abstract: The recoverable yield of recombinant human albumin in the fermentation of genetically engineered yeast that expresses the albumin and secretes it into the culture medium is increased by the addition of a stabilizing agent comprising a polyoxyalkylene compound, for example, polypropylene glycol or a polyoxypropylene/polyoxyethylene copolymer. The presence of these compounds in concentrations of from about 0.5 to 10 g per liter, preferably 1 to 5 g per liter, of fermentation broth prevents the degradation of the rHA produced under intensive fermentation conditions thereby raising the effective yield.

Abstract: The universal pulse oximeter probe [of the present invention] utilizes an inexpensive sensor connector configuration to enable the cable section of the probe to be used numerous times. The [sensor connector is mechanically simple and electrically reliable to interconnect the sensor elements with the cable that connects the pulse oximeter system to the sensor elements. This sensor connector enables the user to obtain significant benefits due to the fact that the expensive cable segment of the probe is a separable element from the housing that contains the sensor elements. In particular, the] cable segment of the probe consists of a connector that is compatible with the pulse oximeter system and which functions to interconnect the pulse oximeter system with a plurality of conductors, the far end of which are terminated in the sensor connector [of the present invention].