Abstract: Aminomethylene phosphonates, which give excellent inhibition of the formation, deposition and adherence of scale-forming salts, especially calcium carbonate, in aqueous systems, are degraded by the oxidizing biocides bromine and chlorine used to control microbial growth in such aqueous systems. It has been found that organic sulfonamides provide excellent protection against such degradation when they are added to the aqueous system along with the aminomethylene phosphonate scale inhibitors.
Abstract: 3-Phosphonate carbapenems of the Formula: wherein R.sup.1 is hydrogen, alkyl, amino, --NHCO-alkyl, hydroxy, alkoxy, halo, hydroxyalkyl, carboxyl or trifluoromethyl; R.sup.2 is alkyl, substituted alkyl, heterocyclic or substituted heterocyclic; R.sup.3 is hydrogen, alkyl or substituted alkyl; and M is a metal cation of H.sup.+ are disclosed. The compounds are useful as antibiotics.
Type:
Grant
Filed:
September 6, 1983
Date of Patent:
January 21, 1986
Assignee:
Merck & Co., Inc.
Inventors:
W. Alexander Andrus, Burton G. Christensen, James V. Heck