Patents Represented by Attorney R. Neil Siebel

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  • L-.beta.-dioxolane uridine analog administration for treating Epstein-Barr virus infection
    Patent number: 5792773
    Abstract: The present invention relates to the discovery that certain .beta.-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV infections in humans.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: August 11, 1998
    Assignees: Yale University, University of Georgia Research Foundation
    Inventors: Chung K. Chu, Yung-Chi Cheng, Fucheng Qu