Patents Represented by Attorney, Agent or Law Firm R. R. Barrett
  • Preparation of N1-(2?-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
    Patent number: 6784294
    Abstract: A process for making an N1-(2′-pyridyl)-1,2-alkanediamine sulfamic acid of formula II by reacting a compound of formula I with NH2R′ wherein R and R′ are as defined in the specification. The invention also includes the compound of formula II, and optical isomers thereof. The compound of formula II is an intermediate useful for making chiral piperazine derivatives which are active at the 5-HT1A receptor.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: August 31, 2004
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Gregg Brian Feigelson, Joseph Zeldis, Ivo Jirkovsky