Patents Represented by Attorney R. Steve Thomas

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  • N-(5-membered aromatic ring)-amido anti-viral compounds
    Patent number: 7595398
    Abstract: Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: September 29, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Ronald Conrad Griffith, Martin Robert Leivers, Irina Slobodov, Roopa Rai
  • Imidazol-2-one compounds useful in the treatment of various disorders
    Patent number: 7534893
    Abstract: A compound of formula (I) wherein: R is a group selected from: A-B is a bivalent radical of formula (v), (vi) or (vii) —CH?C(R11)—??(v) —C(R10)?CH— or??(vi) —C(R12)(R10)—C(R11)(R13)—??(viii) and all other variables are as defined herein or a pharmaceutically acceptable salt or solvate thereof, process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: May 19, 2009
    Assignee: Glaxo Group Limited
    Inventors: Giuseppe Alvaro, Damiano Ghirlanda
  • Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases
    Patent number: 7482365
    Abstract: The present invention relates to piperidine derivatives of formula (I): wherein R, R1, R2, R3, R4, R5, R6, X, Y, m and n are as defined herein; and pharmaceutically acceptable salts and solvates thereof; the process for their preparation and their use in the treatment of conditions mediated by tachykinins.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: January 27, 2009
    Assignee: Glaxo Group Limited
    Inventors: Giuseppe Alvaro, Alfredo Paio, Alessandro Pontiroli, Simone Spada, Maria Elvira Tranquillini
  • Pyrrolidine-2-ones as Factor Xa inhibitors
    Patent number: 7482374
    Abstract: The invention relates to compounds of formula (I): wherein substituents are as defined.
    Type: Grant
    Filed: July 17, 2004
    Date of Patent: January 27, 2009
    Assignee: Glaxo Group Limited
    Inventors: Alan David Borthwick, Henry Anderson Kelly, Nigel Stephen Watson, Robert John Young
  • (2S,4S)-4-fluoro-1-[4-fluoro-beta-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile -toluenesulfonic acid salt and anhydrous crystalline forms thereof
    Patent number: 7462641
    Abstract: The present invention includes anhydrous crystalline forms of (2S,4S)-4-fluoro-1-[4-fluoro-?-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt.
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: December 9, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: David H Igo, Paul R Johnson, Daniel E Patterson, Amarjit Sab Randhawa
  • Phenyl compounds
    Patent number: 7446222
    Abstract: Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 4, 2008
    Assignee: Glaxo Group Limited
    Inventors: Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Neil Derek Miller, Tiziana Scoccitti
  • Pyrrolidine derivatives as factor Xa inhibitors
    Patent number: 7429587
    Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: September 30, 2008
    Assignee: Glaxo Group Limited
    Inventors: Chuen Chan, Julie Nicole Hamblin, Henry Anderson Kelly, Nigel Paul King, Andrew McMurtrie Mason, Vipulkumar Kantibhai Patel, Stefan Senger, Gita Punjabhai Shah, Nigel Stephen Watson, Helen Elisabeth Weston, Caroline Whitworth, Robert John Young
  • Process for preparing substituted benzimidazole compounds
    Patent number: 7375235
    Abstract: The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: May 20, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Stephen Freeman
  • Crystal form
    Patent number: 7112670
    Abstract: The present invention involves a novel crystal form of 17?-hydroxy-7?-(5?-methyl-2?-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, ?-lactone, having the formula which is an intermediate useful in preparation of an important pharmaceutical, eplerenone.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: September 26, 2006
    Assignee: Pharmacia Corporation
    Inventors: Bruce Allen Pearlman, Frederick J. Antosz