Patents Represented by Attorney Rachel A. Polster
-
Patent number: 7807802Abstract: Polynucleotides useful for detecting Neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same.Type: GrantFiled: November 12, 2002Date of Patent: October 5, 2010Inventors: Edward K. Pabich, Ronald L. Marshall, Hong Yu
-
Patent number: 7462724Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).Type: GrantFiled: November 15, 2006Date of Patent: December 9, 2008Assignee: Abbott LaboratoriesInventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent L. Giranda, Viraj B. Gandhi
-
Patent number: 6900232Abstract: The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.Type: GrantFiled: June 15, 2001Date of Patent: May 31, 2005Assignee: Pharmacia CorporationInventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu
-
Patent number: 6833366Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.Type: GrantFiled: September 9, 2003Date of Patent: December 21, 2004Assignee: Pharmacia CorporationInventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan
-
Patent number: 6831199Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, wherein A is pharmaceutical compositions thereof and methods of using such compounds and compositions as &agr;v&bgr;3 antagonists.Type: GrantFiled: December 18, 1998Date of Patent: December 14, 2004Assignee: G. D. Searle & Co.Inventors: Peter Gerrard Ruminski, Michael Clare, Paul Waddell Collins, Bipinchandra Nanubhai Desai, Richard John Lindmark, Joseph Gerace Rico, Thomas Edward Rogers, Mark Andrew Russell
-
Patent number: 6794385Abstract: The present invention relates to a class of compounds represented by the formula (I) or a pharmaceutical acceptable salt, prodrug or ester thereof, pharmaceutical compositions comprising compounds of the formula (I), and methods of selectively inhibiting or antagonizing &agr;v&bgr;3 integrin.Type: GrantFiled: August 8, 2001Date of Patent: September 21, 2004Assignee: Pharmacia & Upjohn, S.p.A.Inventors: Paola Vianello, Tiziano Bandiera, Mario Varasi
-
Patent number: 6750215Abstract: The present invention relates to a class of compounds represented by the formula (I) or a pharmaceutical acceptable salt, prodrug or ester thereof, pharmaceutical compositions comprising compounds of the formula (I), and methods of selectively inhibiting or antagonizing &agr;v&bgr;3 integrin.Type: GrantFiled: August 8, 2001Date of Patent: June 15, 2004Assignee: Pharmacia & Upjohn, S.p.A.Inventors: Paola Vianello, Tiziano Bandiera
-
Patent number: 6720315Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.Type: GrantFiled: June 15, 2001Date of Patent: April 13, 2004Assignee: Pharmacia CorporationInventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan, Heather Stenmark
-
Patent number: 6720327Abstract: The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.Type: GrantFiled: September 26, 2001Date of Patent: April 13, 2004Assignee: Pharmacia CorporationInventors: Peter Ruminski, Thomas D. Penning, Lan Jiang, Balekudru Devadas, Thomas Rogers, Jennifer VanCamp, Chester Yuan
-
Patent number: 6689787Abstract: The present invention provides methods to treat neoplasia disorders in a mammal using a combination of radiation and an integrin antagonist.Type: GrantFiled: October 5, 2001Date of Patent: February 10, 2004Assignee: G. D. Searle & Co.Inventors: John P. McKearn, Gary Gordon, James J. Cunningham, Stephen T. Gately, Alane T. Koki, Jaime L. Masferrer
-
Patent number: 6689754Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the &agr;v&bgr;3 integrin.Type: GrantFiled: April 8, 1999Date of Patent: February 10, 2004Assignee: G. D. Searle & Co.Inventors: Nizal Samuel Chandrakumar, Bipinchandra Nanubhai Desai, Balekudru Devadas, Alan Frank Gasiecki, Renee Huff, Ish K. Khanna, James W. Malecha, Julie M. Miyashiro, Shashidhar N. Rao, Joseph Gerace Rico, Thomas Edward Rogers, Peter Gerrard Ruminski, Mark Andrew Russell, Yi Yu
-
Patent number: 6682727Abstract: The present invention relates to site-specific conjugation of synthetic particles to proteins.Type: GrantFiled: October 18, 2001Date of Patent: January 27, 2004Assignee: G. D. Searle & Co.Inventors: Stephen C. Lee, Ranjani V. Parthasarathy
-
Patent number: 6677308Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.Type: GrantFiled: August 28, 1998Date of Patent: January 13, 2004Assignee: G. D. Searle & Co.Inventors: Nizal Chandrakumar, Michael Clare, Wendell Doubleday, Alan F. Gasiecki, Mark A. Russell
-
Patent number: 6673784Abstract: A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II wherein each of R1, R2, and R3 is independently selected from hydrido, halo, and nitro; wherein R8 is selected from haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted arylalkoxy and optionally substituted aryloxyalkyl; where Y is selected from fluoroalkyl, and wherein R9 alkylamino; or a pharmaceutically-acceptable salt or tautomer thereof.Type: GrantFiled: November 14, 2000Date of Patent: January 6, 2004Assignee: G. D. Searle & Co.Inventors: Daniel L. Flynn, Jeffery Zablocki, Kenneth Williams, Susan L. Hockerman
-
Patent number: 6673788Abstract: A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II: wherein each of R1, R2, and R3 is independently selected from hydrido, halo, and nitro; wherein R8 is selected from haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted arylalkoxy and optionally substituted aryloxyalkyl; wherein Y is selected from fluoroalkyl, and and wherein R9 is alkylamino; or a pharmaceutically-acceptable salt or tautomer thereof.Type: GrantFiled: November 25, 2002Date of Patent: January 6, 2004Assignee: G. D. Searle & Co.Inventors: Daniel L. Flynn, Jeffery Zablocki, Kenneth Williams, Susan L. Hockerman
-
Patent number: 6531494Abstract: The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.Type: GrantFiled: August 29, 2001Date of Patent: March 11, 2003Assignee: Pharmacia CorporationInventors: Ish Kumar Khanna, Yi Yu, Balekudru Devadas, Hwang-Fun Lu, Nizal S Chandrakumar, Renee M. Huff, Bipinchandra N. Desai, Srinivasan Raj Nagarajan, Alan F. Gasiecki, Thomas D. Penning, Mark A. Russell, Mark L. Boys, Lori A. Schretzman, Barbara B. Chen, Thomas Rogers, John Adam Wendt, Albert Khilevich, Yaping Wang
-
Patent number: 6485718Abstract: The present invention relates to site-specific conjugation of synthetic particles to proteins.Type: GrantFiled: April 11, 2000Date of Patent: November 26, 2002Assignee: Pharmacia CorporationInventors: Rajani V. Parthasarathy, Stephen C. Lee
-
Patent number: 6414180Abstract: The invention herein is directed to a process for the preparation of chiral &bgr;-amino acids and esters of the formula wherein X and Y are the same or different halo groups, R2 is H or lower alkyl and isomers and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 2, 1999Date of Patent: July 2, 2002Assignee: G. D. SearleInventors: Pierre-Jean Colson, Alok K. Awasthi, Srinivasan R. Nagarajan
-
Patent number: 6372719Abstract: The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.Type: GrantFiled: March 4, 1999Date of Patent: April 16, 2002Inventors: Jay Cunningham, Gary B. Gordon, G. Allen Nickols, William F. Westlin, Thomas Edward Rogers, Peter Gerrard Ruminski
-
Patent number: 6251944Abstract: The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.Type: GrantFiled: April 8, 1999Date of Patent: June 26, 2001Assignee: G. D. Searle & CompanyInventors: Barbara B. Chen, Helen Y. Chen, Glen J. Gesicki, Richard A. Haack, James W. Malecha, Thomas D. Penning, Joseph G. Rico, Thomas E. Rogers, Peter G. Ruminski, Mark A. Russell, Stella S. Yu