Patents Represented by Law Firm Rae-Venter & Associates
  • DNA sequence-based HLA class I typing method
    Patent number: 5593830
    Abstract: The present invention provides a process for determining genotypes in highly polymorphic systems by polymerase chain reaction amplification of cDNA or genomic DNA and direct sequencing polymerase chain reaction products using oligonucleotide primers. More specifically, Class I HLA genotypes can be unambiguously determined in any subject in 16-24 hours by direct sequencing of HLA-A, HLA-B, and HLA-C transcripts enzymatically amplified and sequenced using a limited number of selected oligonucleotide.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: January 14, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Pedro Santamaria, Michael T. Boyce-Jacino, Jose J. Barbosa, Stephen S. Rich, Anthony J. Faras
  • Use of a pregnancy specific protein as an immunosuppressive
    Patent number: 5559097
    Abstract: Methods and compositions are provided for maintaining pregnancy and preventing rejection of transplanted tissue. A polypeptide characterized as capable of isolation from conceptus tissue and capable of inhibiting mitogen induced lymphocyte blastogenesis is employed which is introduced into the uterus or systemically.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: September 24, 1996
    Assignee: Idaho Research Foundation, Inc.
    Inventor: R. Garth Sasser