Abstract: Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to bone tissue engineering. Preferably, hydroxyapatite ("HA") granules are incorporated into the blends and the resulting blends have desirable mechanical, physical, and biological characteristics. Even more preferably the compositions of the present invention are utilized to form osteoconductive composites that supported bone cell growth on the surface as well as throughout the scaffold.
Type:
Grant
Filed:
November 19, 1998
Date of Patent:
December 26, 2000
Assignees:
Carnegie Mellon University, University of Pittsburgh
Inventors:
Kacey G. Marra, Lee E. Weiss, Jay Wynn Calvert, Prashant N. Kumta
Abstract: A three-dimensional scaffold for tissue generation. Mechanical fasteners allow layered and volumetric scaffold sections, which may be pre-seeded with cells and/or growth factors, to be assembled into a heterogeneous generated tissue for implantation.
Type:
Grant
Filed:
March 26, 1998
Date of Patent:
November 7, 2000
Assignees:
Carnegie Mellon, University of Pittsburgh
Abstract: An ultrasonic surgical liposuction apparatus comprises a piezoelectric cral transducer assembly is connectable with a push rod house within the housing which allows the use of interchangeable operative probe and tip. The probe can be hollow, if aspiration of the fatty tissue is desired, or it can be solid.
Type:
Grant
Filed:
September 18, 1997
Date of Patent:
June 6, 2000
Assignee:
The California Institute of Tissue Engineering and Instrumentation, LLC