Patents Represented by Attorney Raymond McDonald

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  • Aminoacyl derivatives of aminoglycoside antibiotics
    Patent number: 4117221
    Abstract: Disclosed herein are novel 1-N-X-aminoglycoside anti-bacterial agents produced from antibiotics elaborated by species of the genus Micromonospora wherein X is a member selected from the group consisting of S-3-amino-2-hydroxypropionyl and S-4-amino-2-hydroxybutyryl and S-5-amino-2-hydroxypentanoyl. Also disclosed are novel intermediates in the production of the foregoing.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: September 26, 1978
    Assignee: Schering Corporation
    Inventor: Peter J. L. Daniels
  • Process for preparing 2-halogeno nicotinic acids
    Patent number: 4081451
    Abstract: This invention relates to a novel process for preparing 2-halogeno-nicotinic acids. The compounds, especially 2-chloro-nicotinic acid, are intermediates in the preparation of anilino nicotinic acid derivatives. The latter compounds are useful as analgesic anti-diarrheal and anti-inflammatory agents.
    Type: Grant
    Filed: April 4, 1977
    Date of Patent: March 28, 1978
    Assignee: Schering Corporation
    Inventor: Joseph Mayer
  • Rosamicin derivatives and method of using same
    Patent number: 4056616
    Abstract: Rosamicin is an antibiotic elaborated by Micromonospora rosaria. The compounds described herein are antibacterial derivatives of rosamicin. Also described are processes for the preparation of these antibacterial derivatives from rosamicin.
    Type: Grant
    Filed: March 5, 1976
    Date of Patent: November 1, 1977
    Assignee: Schering Corporation
    Inventors: Hans Reimann, Robert S. Jaret, Mohammad Mehdi Nafissi-Varchei
  • Substituted aryl and aralkyl amides
    Patent number: 4053509
    Abstract: Amides having aromatic substituents of the formula: ##STR1## wherein R is an acyl radical derived from a carboxylic acid having from 3 to 20 carbon atoms, X and Y are members selected from the group consisting of hydrogen, fluoro, trifluoromethyl and hydroxy, and n is an integer selected from the group consisting of 0, 1 and 2, exhibit an effect upon the central nervous system.
    Type: Grant
    Filed: March 15, 1973
    Date of Patent: October 11, 1977
    Assignee: Schering Corporation
    Inventors: Hans-Peter Faro, Samson Symchowicz
  • Selective acylation of the C-1 amino group of aminoglycoside antibiotics
    Patent number: 4029882
    Abstract: A novel process for preparing novel 1-N-acyl-4,6-di-(aminoglycosyl)aminocyclitols is disclosed. The compounds are useful as antibacterial agents.
    Type: Grant
    Filed: March 19, 1974
    Date of Patent: June 14, 1977
    Assignee: Schering Corporation
    Inventor: John J. Wright
  • Antibiotic 67-121, a polyene antifungal antibiotic produced by actinoplanes caeruleus
    Patent number: 4027015
    Abstract: A microorganism of the genus Actinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: May 31, 1977
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Novel monoesters of rosamicin
    Patent number: 4017516
    Abstract: Described herein are novel monoesters of rosamicin, also known as Antibiotic 67-694. Also described is a process for the preparation of such esters by the selective solvolysis of diester precursors. The monoesters are broad spectrum antibacterial agents but are generally more effective against gram-positive bacteria.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: April 12, 1977
    Assignee: Schering Corporation
    Inventor: Hans Reimann
  • Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
    Patent number: 4011390
    Abstract: Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: June 5, 1974
    Date of Patent: March 8, 1977
    Assignee: Schering-Plough Corporation
    Inventors: Marvin J. Weinstein, Peter J. L. Daniels, Gerald H. Wagman, Raymond Testa
  • Antibiotic compositions and methods from micromonospora purpurea JI-20
    Patent number: 4009269
    Abstract: A mutant strain of Micromonospora purpurea herein designated M. purpurea JI-20 elaborates an antibiotic complex comprising gentamicin and at least two novel antibiotic substances namely Antibiotic JI-20A and Antibiotic JI-20B. The so-produced antibiotics have an adverse effect upon the growth of gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: February 22, 1977
    Assignee: Schering Corporation
    Inventors: Jan Ilavsky, Aris P. Bayan, William Charney, Hans Reimann