Patents Represented by Attorney Raynard Yuro

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  • Benzimidazolinyl piperidines as CGRP ligands
    Patent number: 6552043
    Abstract: The present invention relates to benzimidazolinylpiperidine derivatives useful as ligands for CGRP (Calcitonin Gene-Related Peptide) receptors, their use in therapy, pharmaceutical compositions comprising them and methods of treatment using them.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: April 22, 2003
    Assignees: Merck Sharpe & Dohme Ltd., Merck & Co, Inc.
    Inventors: Arthur A. Patchett, Raymond George Hill, Lihu Yang
  • Synthesis of ketosulfone esters
    Patent number: 6495713
    Abstract: This invention encompasses a process for making a compound of Formula A These compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammnatory agents.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: December 17, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Cheng Yi Chen, Weirong Chen, Paul O'Shea, Lushi Tan, Richard Tillyer, Feng Xu, Philippe Dagneau
  • Treatment or prevention of prostate cancer with a COX-2 selective inhibiting drug
    Patent number: 6486204
    Abstract: A COX-2 selective inhibiting drug is disclosed as useful in treating or preventing prostate cancer. The compound is used alone or in combination with other drugs.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: November 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Joanne Waldstreicher, Briggs W. Morrison
  • Pyrazinones, compositions containing such compounds and methods of use
    Patent number: 6444811
    Abstract: Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat fin caspase-3 mediated diseases and conditions.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: September 3, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Yongxin Han, Andre Giroux, Robert Zamboni, Daniel J. McKay, Christopher I. Bayly, Erich L. Grimm, John Colucci
  • Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonyphenyl)-6'- methyl-[2,3']bipyridinyl
    Patent number: 6441002
    Abstract: Polymorphic, amorphous and hydrated forms of the title compound having the following structure: are disclosed. The compound is a potent and selective cyclooxygenase-2 (COX-2) inhibitor.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: August 27, 2002
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.
    Inventors: Sophie Dorothee Clas, Louis S. Crocker, James A. McCauley, Ian Davies, Chad Dalton
  • PDE IV inhibiting amides, compositions and methods of treatment
    Patent number: 6436965
    Abstract: Compounds represented by formula I: as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by PDE-IV. Pharmaceutical compositions and methods of treatment are also included.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: August 20, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Marc Labelle, Claudio Sturino, Nicolas Lachance, Dwight Macdonald
  • Phosphate derivatives as immunoregulatory agents
    Patent number: 6437165
    Abstract: Immunoregulatory compounds are disclosed of the formula: as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: August 20, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Suzanne Mandala, James Bergstrom, Richard Hajdu, Hugh Rosen, William Parsons, Deborah J. Card, Malcolm Maccoss, Rupprecht Kathleen
  • Method for treating chronic prostatitis or chronic pelvic pain syndrome
    Patent number: 6403640
    Abstract: The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: June 11, 2002
    Assignees: Merck & Co., Inc., Temple University of the Commonwealth of Higher Ed.
    Inventors: Elizabeth Stoner, Joanne Waldstreicher, Curtis J. Nickel, Michel A. Pontari
  • Method of treating migraines and pharmaceutical compositions
    Patent number: 6384034
    Abstract: A combination of a 5HT1B/1D agonist and a COX-2 selective inhibitor is useful in the treatment and or prevention of migraine.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: May 7, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Kremena Simitchieva, Scott A. Reines, Errol McKinney, Eric J. Sandquiest, Deepak K. Khannna, Richard Hargreaves
  • Hexahydro-5-imino-1,4-1,4-thiazepine derivatives as inhibitors of nitric oxide synthases
    Patent number: 6372733
    Abstract: Disclosed herein are compounds of Formula I and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of gastrointestinal motility and inflammation.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: April 16, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Charles G. Caldwell, Malcolm Maccoss, William K. Hagmann, Shrenik K. Shah, Kothandaraman Shankaran, Karla L. Furman
  • Process for making diaryl pyridines useful as cox-2 inhibitors
    Patent number: 6369275
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: April 9, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Ian W. Davies, Michel Journet, Linda Gerena, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
    Patent number: 6369082
    Abstract: This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 9, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Patrick Lacombe, Marc Labelle, Rejean Ruel
  • Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
    Patent number: 6369084
    Abstract: This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses certain pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases comprising the use of compounds of formula A.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 9, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Patrick Lacombe, Marc Labelle, Rejean Ruel
  • Chromophore containing compounds and their use in determining interleukin-1&bgr; convertase activity
    Patent number: 6348570
    Abstract: Disclosed are novel chromophore containing compounds of Formula I and their use in determining interleukin-1&bgr; convertase (ICE) activity. ICE has been implicated in inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes.
    Type: Grant
    Filed: December 17, 1991
    Date of Patent: February 19, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Kevin T. Chapman, Malcolm Maccoss, Richard A. Mumford, Nancy A. Thornberry, Jeffrey R. Weidner, William K. Hagmann
  • Biphenylene lactams as prostaglandin receptor ligands
    Patent number: 6277839
    Abstract: The present invention relates to biphenylene lactams of Formula II which are ligands at the prostaglandin receptors, as well as a method for treating prostaglandin mediated diseases comprising administration to a patient in need of such a treatment of a non-toxic therapeutically effective amount of compound of Formula II, and the like.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: August 21, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Joseph G. Atkinson, Marc Labelle, Patrick Lacombe, Rejean Ruel
  • Intermediates useful in a process for synthesizing COX-2 inhibitors
    Patent number: 6252116
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 26, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Edward G. Corley, Ian W. Davies, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
    Patent number: 6242493
    Abstract: Compounds of formula I: as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: June 5, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Yves Gareau, Marc LaBelle, Helene Juteau, Michel Gallant, Nicolas LaChance, Michel Belley
  • Synthesis of 4-[(5-substituted phenyl)-3-substituted-1H-pyrazol-1-yl]benzenesulfonamide
    Patent number: 6232472
    Abstract: This invention encompasses a novel process for synthesizing the compound represented by formula I: These compounds are useful as non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: May 15, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Paul O'Shea, Xin Wang, Richard D. Tillyer, Sophie-Dorothee Clas, Chad Dalton
  • Gamma-ketoacid dipeptides as inhibitors of caspase-3
    Patent number: 6225288
    Abstract: Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: May 1, 2001
    Assignee: Merk Frosst Canada & Co.
    Inventors: Yongxin Han, Andre Giroux, Erich Grimm, Renee Aspiotis, Sebastien Francoeur, Robert Zamboni, Petpiboon Prasit, Christopher Bayly, Dan McKay, Cameron Black
  • Diaryl-2-(5H)-furanones as Cox-2 inhibitors
    Patent number: 6222048
    Abstract: The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: April 24, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Cameron Black, Erich Grimm, Serge Leger, Petpiboon Prasit, Zhaoyin Wang