Abstract: The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.
Type:
Grant
Filed:
October 31, 2001
Date of Patent:
December 30, 2003
Assignee:
AGY Therapeutics, Inc.
Inventors:
Mirella Gonzalez-Zulueta, Mehrdad Shamloo, K.C. McFarland, Daniel Chin, Tadeusz Wieloch, Thorsten Melcher
Abstract: The invention relates to a human phospholipase C expressed in the brain (B-PLC) and induced in response to ischemic brain tissue. The inventions provides methods and reagents useful for diagnosis and treatment of hypoxic-ischemic brain insult such as stroke.
Type:
Grant
Filed:
October 13, 2000
Date of Patent:
December 9, 2003
Assignee:
AGY Therapeutics, Inc.
Inventors:
Kalev Kask, Thorsten Melcher, Daniel J. Chin