Abstract: A process and system for continuous assay and removal of toxins from tobacco. Products such as tobacco contaminated with mycotoxins, particularly aflatoxins, and benzpyrene and its precursors, are subjected to treatment, generally in a solvent medium, to decontaminate the tobacco of the toxin. Continuous monitoring of all harmful toxins eluted from the cleaning solvent is performed by immunoantibody ultraviolet fluorescence, for example. A quality-control process ensures removal of harmful toxins from tobacco before further processing. Decontamination of extracted solvent streams and re-additives ensures safe reuse or disposal of the solvents and re-additives.