Patents Represented by Attorney Renèe S. Polizotto

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  • Methods and materials relating to CD84-like polypeptides and polynucleotides
    Patent number: 7425610
    Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polyeptides.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: September 16, 2008
    Assignee: Nuvelo, Inc.
    Inventors: Chiaoyun Kuo, Bryan J. Boyle, Jian-Rui Wang, Y. Tom Tang, Chenghua Liu, Radoje T. Drmanac
  • Methods of therapy and diagnosis using immunotargeting of CD84Hy1-expressing cells
    Patent number: 7378253
    Abstract: Certain cells, including types of cancer cells such as lymphomas, are capable of expressing high levels of CD84Hy1. Immunotargeting using CD84Hy1 polypeptides, nucleic acids encoding for CD84Hy1 polypeptides and anti-CD84Hy1 antibodies provides a method of killing or inhibiting that growth of CD84HY1Protein-expressing cancer cells. Methods of immunotherapy and diagnosis of disorders associated with CD84Hy1 protein-expressing cells are described.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: May 27, 2008
    Assignee: Novelo, Inc.
    Inventors: Douglas Dedera, Jian Rui Wang, Peter Emtage
  • Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides
    Patent number: 7109030
    Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: September 19, 2006
    Assignee: Nuvelo, Inc.
    Inventors: Douglas A. Dedera, Victoria Yamazaki, Vinod Asundi, Chenghua Liu, Y. Tom Tang, Radoje T. Drmanac
  • Methods of therapy and diagnosis using immunotargeting of CD84Hy1-expressing cells
    Patent number: 7029677
    Abstract: Certain cells, including types of cancer cells such as lymphomas, are capable of expressing high levels of CD84Hy1. Immunotargeting using CD84Hy1 polypeptides, nucleic acids encoding for CD84Hy1 polypeptides and anti-CD84Hy1 antibodies provides a method of killing or inhibiting that growth of CD84HY1Protein-expressing cancer cells. Methods of immunotherapy and diagnosis of disorders associated with CD84Hy1protein-expressing cells are described.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: April 18, 2006
    Assignee: Nuvelo, Inc.
    Inventors: Douglas Dedera, Jian-Rui Wang, Peter C. R. Emtage
  • Methods and materials relating to novel CD39-like polypeptides
    Patent number: 6858207
    Abstract: The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a novel human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing novel CD39-like polypeptides, and antibodies specific for such polypeptides.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: February 22, 2005
    Assignee: Nuvelo, Inc.
    Inventors: John Ford, Julio J. Mulero
  • Methods and compositions relating to CD39-like polypeptides and nucleic acids
    Patent number: 6828423
    Abstract: The present invention provides polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: December 7, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Brian Paul Chadwick, Anna-Maria Frischauf
  • Methods and materials relating to semaphorin-like polynucleotides
    Patent number: 6818754
    Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: November 16, 2004
    Assignee: Nuvelo. Inc.
    Inventors: Bryan J. Boyle, George Yeung, Matthew C. Arterburn, Nancy K. Mize, Y. Tom Tang, Chenghua Liu, Radoje T. Drmanac
  • Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
    Patent number: 6808890
    Abstract: The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention are useful for detecting cancers.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: October 26, 2004
    Assignee: Nuvelo, Inc.
    Inventors: John E. Ford, George Yeung, Hua Zhou
  • Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides
    Patent number: 6806254
    Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted alpha-2-macroglobulin-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal brain mRNA (Clontech) (SEQ ID NO: 1) and uterus mRNA (Clontech) (SEQ ID NO: 26). Other aspects of the invention include vectors containing processes for producing novel human secreted alpha-2-macroglobulin-like polypeptides, and antibodies specific for such polypeptides.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: October 19, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Shubhada D. Godbole, Bryan J. Boyle, Nancy K. Mize, Cenhua Deng, Ryle W. Goodrich, Matthew C. Arterburn, Ping Zhou, Y. Tom Tang, Chenghua Liu, George Yeung, Radoje T. Drmanac
  • Method of detecting a cancerous cell expressing an EGF motif polynucleotide
    Patent number: 6800443
    Abstract: The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention are useful for detecting cancers.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: October 5, 2004
    Assignee: Nuvelo, Inc.
    Inventors: John E. Ford, George Yeung, Hua Zhou
  • Methods and compositions relating to CD39-like polypeptides and nucleic acids
    Patent number: 6787328
    Abstract: The present invention provides polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: September 7, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Brian Paul Chadwick, Anna-Maria Frischauf
  • Methods and compositions relating to CD39-like polypeptides and nucleic acids
    Patent number: 6783959
    Abstract: The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: August 31, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Brian Paul Chadwick, Anna-Maria Frischauf
  • Methods and compositions relating to CD39-like polypeptides and nucleic acids
    Patent number: 6780410
    Abstract: The present invention provides polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: August 24, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Brian Paul Chadwick, Anna-Maria Frischauf
  • Methods and compositions relating to CD39-like polypeptides and nucleic acids
    Patent number: 6780977
    Abstract: The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: August 24, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Brian Paul Chadwick, Anna-Maria Frischauf
  • Growth factor antagonist materials and methods
    Patent number: 6706871
    Abstract: The present invention provides nucleic acids encoding Sprouty related human growth factor antagonist proteins (designated FGFAn-Hy), the polypeptides encoded by these nucleic acids and uses of these and related products.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: March 16, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Dennis G. Ballinger, Julie Reeder Montgomery
  • Antibodies specific for semaphorin-like polypeptides
    Patent number: 6635742
    Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: October 21, 2003
    Assignee: Nuvelo, Inc.
    Inventors: Bryan J. Boyle, George Yeung, Matthew C. Arterburn, Nancy K. Mize, Y. Tom Tang, Chenghua Liu, Radoje T. Drmanac