Patents Represented by Attorney, Agent or Law Firm Renee M. Kosslak
  • Tissue collection devices containing biosensors
    Patent number: 6833267
    Abstract: The present disclosure provides tissue collection devices comprising biosensors that can be used for the detection of target analytes, such as nucleic acids and proteins, including antibodies and enzymes.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: December 21, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Protein and peptide sensors using electrical detection methods
    Patent number: 6824669
    Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: November 30, 2004
    Assignee: Motorola, Inc.
    Inventors: Changming Li, Jaymie Robin Sawyer, Vi-En Choong, George Maracas, Peiming Zhang
  • Apparatus and method for automated protein design
    Patent number: 6804611
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 12, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Use of cytokines, cells and mitogens to inhibit graft versus host disease
    Patent number: 6803036
    Abstract: The field of the invention is generally related to pharmaceutical agents useful in treating graft-versus-host disease (GVHD) in patients that have received allogenic bone marrow transplants.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: October 12, 2004
    Assignee: University of Southern California
    Inventor: David A. Horwitz
  • Apparatus and method for automated protein design
    Patent number: 6801861
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: October 5, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Use of cytokines and mitogens to inhibit pathological immune responses
    Patent number: 6797267
    Abstract: The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: September 28, 2004
    Assignee: University of Southern California
    Inventor: David A. Horwitz
  • Apparatus and method for automated protein design
    Patent number: 6792356
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: September 14, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Magnetic resonance imaging agents for the detection of physiological agents
    Patent number: 6770261
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: August 3, 2004
    Assignee: Research Corporation Technologies
    Inventors: Thomas J. Meade, Scott Fraser
  • Printed circuit boards with monolayers and capture ligands
    Patent number: 6761816
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: July 13, 2004
    Assignee: Clinical Micro Systems, Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
  • Method to prevent graft rejection using TGF-beta to induce T suppressor cells
    Patent number: 6759035
    Abstract: The invention relates to compositions and methods useful for preventing graft rejection in a recipient following organ transplantation.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: July 6, 2004
    Assignee: University of Southen California
    Inventor: David A. Horwitz
  • Target analyte detection using asymmetrical self-assembled monolayers
    Patent number: 6753143
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: June 22, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Chunlin Tao, Changjun Yu
  • Proteins with insulin-like activity useful in the treatment of diabetes
    Patent number: 6746853
    Abstract: The invention relates to novel insulin activity (IA) proteins and nucleic acids. The Invention further relates to the use of the IA proteins in the treatment of insulin related disorders such as type 1 diabetes and type 2 diabetes.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 8, 2004
    Assignee: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Andrew G. Morton
  • Method for increasing the permeability of wood
    Patent number: 6742278
    Abstract: The present invention relates to the treatment of wood, and is particularly concerned with a method for increasing the permeability of wood, especially moist wood.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 1, 2004
    Assignee: The University Of Melbourne
    Inventors: Peter Vinden, Francisco Javier Romero, Grigory Torgovnikov
  • Signal detection techniques for the detection of analytes
    Patent number: 6740518
    Abstract: The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: May 25, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Hau H. Duong, Stephen D. O'Connor, Robert H. Terbrueggen, Jon Faiz Kayyem, Gary T. Olsen, Daniel A. Litvack, Javier Gonzalez
  • Magnetic resonance imaging agents for the delivery of therapeutic agents
    Patent number: 6713046
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: March 30, 2004
    Assignee: Research Corporation Technologies
    Inventor: Thomas J. Meade
  • Targeted magnetic resonance imaging agents for the detection of physiological processes
    Patent number: 6713045
    Abstract: The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: March 30, 2004
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Thomas Meade, Scott Fraser, Russell Jacobs
  • Apparatus and method for automated protein design
    Patent number: 6708120
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 16, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Amplification of nucleic acids with electronic detection
    Patent number: 6686150
    Abstract: The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 3, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Bruce D. Irvine, Jon Faiz Kayyem, Edward Lewis Sheldon, III, Robert H. Terbrueggen
  • Thermostable alkaliphilic xylanase
    Patent number: 6682923
    Abstract: The invention relates to novel xylanase activity (XA) proteins and nucleic acids. The invention further relates to the use of the XA proteins in the process of pulp bleaching.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 27, 2004
    Assignee: Xencor
    Inventors: Jörg Bentzien, Bassil I. Dahiyat
  • Macrocyclic magnetic resonance imaging contrast agents
    Patent number: 6656450
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: December 2, 2003
    Assignee: California Institute of Technology, Inc.
    Inventors: Timothy J. Hubin, Thomas J. Meade