Abstract: The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The peptide derivatives, which comprise a dihydropyridine pyridinium salt-type redox targetor moiety, a bulky lipophilic function and an amino acid/dipeptide/tripeptide spacer, are used in the prevention and treatment of diabetic retinopathy.
Type:
Grant
Filed:
June 21, 2002
Date of Patent:
September 13, 2005
Assignee:
University of Florida
Inventors:
Nicholas Stephen Bodor, Maria Bartolomeo Grant