Patents Represented by Attorney Rhea C. Nersesian

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  • Mutant DNA polymerases with improved pyrophosphorolysis activated polymerization (PAP) ability
    Patent number: 8071536
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: December 6, 2011
    Assignee: Roche Molecular System, Inc.
    Inventors: Keith A Bauer, David Harrow Gelfand
  • Reagents and methods for detecting
    Patent number: 8071303
    Abstract: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: December 6, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Diane Kawa, Shi-Da Lu, Peter Dailey
  • Apparatus for emitting and detecting light in a nucleic acid amplification reaction
    Patent number: 7947442
    Abstract: Subject of the present invention is to provide an apparatus, an instrument, and a method particularly useful in multiplex PCR applications permitting short sample measuring times of many samples combined with high sensitivity.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: May 24, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Roger Iten
  • Synthesis and compositions of nucleic acids comprising 2?-terminator nucleotides
    Patent number: 7928207
    Abstract: The invention provides methods of producing blocked oligonucleotides that include 2?-terminator nucleotides. These blocked oligonucleotides are used primers and probes in a variety of nucleic acid technologies. Related kits are also provided.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: April 19, 2011
    Assignee: Roche Molecular Systems, Inc
    Inventors: Veeraiah Bodepudi, Amar P. Gupta, Stephen G. Will
  • Oligonucleotides, reagents and amplification methods for detecting severe acute respiratory syndrome coronavirus
    Patent number: 7527926
    Abstract: This invention provides oligonucleotides, reagents and amplification methods for detecting the severe acute respiratory syndrome coronavirus (SARS CoV). This invention also provides related compositions, kits, systems, and computers.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: May 5, 2009
    Assignee: Genome Institute of Singapore
    Inventors: Ee Chee Ren, Martin L. Hibberd, Lisa Fong Poh Ng
  • Reagents and methods for detecting
    Patent number: 7476736
    Abstract: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: January 13, 2009
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Diane Kawa, Shi Da Lu, Peter Dailey
  • Detectable labeled nucleoside analogs and methods of use thereof
    Patent number: 7452674
    Abstract: The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing such compounds. The invention further relates to kits comprising labeled imidazole-PEG compounds.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: November 18, 2008
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Veeraiah Bodepudi, Amar Gupta, Stephen G. Will
  • Reference device for evaluating the performance of a confocal laser scanning microscope, and a method and system for performing that evaluation
    Patent number: 7053384
    Abstract: A reference device for evaluating the performance of a confocal laser scan microscope. The reference device comprises a substrate (53) and reference fluorescing matter distributed over a surface of the substrate (53). The reference fluorescing matter has a predetermined spatial distribution over the latter surface.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: May 30, 2006
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Karl Anton Josef Schmid, Urban Georg Schnell