Patents Represented by Attorney, Agent or Law Firm Richa K. Nand, Esq.
  • Methods and pharmaceutical compositions for inhibiting tumor cell growth
    Patent number: 6552055
    Abstract: The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: April 22, 2003
    Assignee: Dana-Farber Cancer Institute
    Inventors: Bruce M. Spiegelman, Elisabetta Mueller, Pasha Sarraf, Soner Altiok, Peter Tontonoz, Samuel Singer
  • Targeted delivery of genes encoding interferon
    Patent number: 6331525
    Abstract: A molecular complex comprising a gene encoding interferon releasably linked to a conjugate of a nucleic acid binding agent and a ligand which binds to a component on the surface of a cell. In a preferred embodiment, the gene encodes human IFN-&agr;, IFN-&bgr;, or IFN-&ggr;. The complex can be used to obtain targeted expression of interferon in selected cells either in vivo or in vitro.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: December 18, 2001
    Assignee: The Immune Response Corporation
    Inventors: Henry C. Chiou, Dennis J. Carlo