Abstract: Herpes virus subunit antigens suitable for vaccine use are prepared by (1) treating virus-infected cells with a surfactant and varying concentrations of salt to extract and solubilize viral-directed glycoproteins, (2) fractionating the solubilized material by chromatographic procedures to enrich the viral-directed glycoproteins and to remove unwanted proteins and nucleic acids, and (3) optionally treating the subunit antigens with deoxyribonuclease and formaldehyde to assure safety.
Abstract: Optionally-foamed polyurethanes are produced by reacting polyisocyanates with organic compounds containing at least two isocyanate-reactive hydrogen atoms and having a molecular weight in the range from 400 to 10,000, in the presence of activators corresponding to the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be the same or different and represent C.sub.1 -C.sub.20 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, C.sub.6 -C.sub.14 -aryl or C.sub.7 -C.sub.30 -alkaryl,X.sup.1 and X.sup.2 may be the same or different and represent halogen or a radical of the formula --OR.sup.5, --SR.sup.6 or ##STR2## with the proviso that X.sup.1 and X.sup.2 cannot both represent a halogen atom,R.sup.5, R.sup.6 and R.sup.7 may be the same or different and represent a C.sub.1 -C.sub.20 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, C.sub.6 -C.sub.14 -aryl or C.sub.7 -C.sub.30 -alkaryl and 1.ltoreq.x.ltoreq.
Type:
Grant
Filed:
October 7, 1982
Date of Patent:
November 29, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Werner Rasshofer, Richard Kopp, Reiner Paul
Abstract: The present invention relates to an apparatus for the production of a solid-forming or a foam-forming reaction mixture from at least two flowable components, the apparatus comprising a mixing head, at the outlet opening of which is connected at an angle a filling tube in which an ejection piston which is designed as a piston head and having a piston rod of a smaller diameter is positioned, the rear neutral position of the piston head being located upstream of the outlet opening of the mixing chamber, characterized in that an introduction slit is provided in the filling tube between the rear neutral position of the piston head of the ejection piston and the outlet opening of the mixing chamber and a delivery device for cleaning platelets is associated with the introduction slit.
Abstract: A new process for the production of very pure 4,4'-diisocyanatodiphenylmethane is disclosed, in which diisocyanatodiphenylmethane isomers which are obtained by distillation from the phosgenation products of aniline/formaldehyde condensates are initially freed from 2,2'- and 2,4'-isomers under certain distillation conditions and are then further worked-up by distillation, in that in a first final stage, from 50 to 90%, by weight of the diisocyanate freed from 2,2'- and 2,4'-isomers is isolated as the head product in the form of pure 4,4'-diisocyanatodiphenylmethane and in a second final stage, another quantity of pure 4,4'-diisocyanatodiphenylmethane is separated as the head product from the distillation of the sump of the first final stage.
Type:
Grant
Filed:
October 25, 1982
Date of Patent:
November 8, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Gunther Ellendt, Gunter Gleitsmann, Max Scheidel
Abstract: This invention relates to new emulsifiers for aqueous isocyanate emulsions and to their use as binders in the production of molded articles, in particular plates, e.g., from materials containing lignocellulose.
Abstract: A process for the preparation of 1,4-3,6-dianhydro-hexitols from hexitols by elimination of water is described, characterized in that gaseous hydrogen halide is used as the acid dehydrating agent optionally with carboxylic acids, carboxylic acid halides and/or carboxylic acid anhydrides in quantities of up to 600 mol percent, based on the hexitols, as cocatalysts. The reaction is carried out in the absence of water and organic solvents, preferably using gaseous hydrogen chloride, temperatures of up to 300.degree. C. and pressures of up to 250 bar. Very high yields are obtained after working up of the product by distillation or extraction.
Type:
Grant
Filed:
March 11, 1982
Date of Patent:
October 4, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Herbert Salzburg, Holger Meyborg, Heinz Ziemann
Abstract: The instant invention is directed to a process for the production of fiber-reinforced molded products, comprising:(1) mixing at a temperature of from 10.degree. to 50.degree. C.,(a) 7 to 35% by weight of a polyisocyanate having a melting point above 100.degree. C.
Type:
Grant
Filed:
September 30, 1980
Date of Patent:
September 20, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus Recker, Gerd Reinecke, Albert Awater, Gerhard Grogler, Karl J. Kraft
Abstract: The present invention relates to a process for the preparation of polyurethane foams capable of being flame laminated and high frequency welded, comprising reacting:(a) polyisocyanate,(b) a compound having a molecular weight of from 400 to 10,000 containing at least two isocyanate-reactive hydrogen atoms and(c) a dialkoxy-phosphonyl-N-alkyl-formic acid amide of the formula: ##STR1## wherein m represents an integer of from 1 to 3,n represents an integer of from 0 to 8,X represents halogen, hydrogen, C.sub.1 to C.sub.6 alkyl, -OR, or ##STR2## R represents C.sub.1 to C.sub.6 alkyl, R.sub.1 represents hydrogen, C.sub.1 to C.sub.10 alkyl, C.sub.1 to C.sub.10 alkylene, C.sub.6 to C.sub.10 aryl or C.sub.6 to C.sub.10 arylene, andR.sub.2 and R.sub.3, which may be the same or different, represent C.sub.1 to C.sub.10 alkyl in the presence of water and/or blowing agent.The present invention also relates to dialkoxy-phosphonyl-N-formic acid amides.
Type:
Grant
Filed:
January 25, 1982
Date of Patent:
August 23, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Peter Haas, Heinz Muller, Peter Seifert, Kuno Wagner, Kurt Findeisen, Klaus Konig
Abstract: The invention relates to a method and a device for producing a reaction mixture from flowable foam-forming or solid-forming components (preferably polyurethane forming components) which are conveyed continuously and are mixed together or are circulated. The quantity to be conveyed is preselected. The injection pressure is preselected and the circulatory pressure is measured for each component. The predetermined quantity and pressure to be conveyed as well as the measured value are preferably fed into a control computer during the circulation and the mixing process and are compared with actual values. Cavities are filled out with the reaction mixture produced and, in particular, molded articles are produced in molds.
Type:
Grant
Filed:
September 2, 1980
Date of Patent:
August 16, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Rolf Coblenz, Klaus Schulte, Wilfried Ebeling, Dieter Evertz
Abstract: The present invention relates to low-halogen-content, thermoplastically-processible polyurethane elastomers (TPU), to which are added antimony trioxide, chlorinated and/or brominated aromatic compounds having a specified halogen content, aluminum hydroxide having a specified particle size, phosphoric acid tris-ester, and, optionally, quaternary tetra-alkyl ammonium salts. These additives impart an unexpectedly favorable combination of electrical surface properties, flameproof behavior and abrasion resistance.
Type:
Grant
Filed:
March 29, 1982
Date of Patent:
August 9, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wilhelm Goyert, Wolfgang Fleige, Hans-Georg Hoppe, Hans Wagner
Abstract: The present invention relates to new azulmic acids stabilized by condensation with carbonyl compounds, several processes for their preparation and their use for various purposes.
Abstract: The present invention relates to an improved process for the catalytic hydrogenation of di(4-aminophenyl) methane to a liquid di(4-aminocyclohexyl) methane mixture containing from 15 to 40% by weight of the trans, trans isomer. The invention resides in the use of a ruthenium-on-alumina catalyst, the use of an aliphatic alcohol during hydrogenation and the use of ammonia during hydrogenation, with the hydrogenation being conducted under specific process conditions. The hydrogenation reaction is conducted for no more than about sixty minutes at a temperature of from 150.degree. to 217.degree. C. and at a hydrogen pressure of at least 500 psi.
Abstract: The present invention relates to an improved process for the catalytic hydrogenation of di(4-amino-phenyl)methane to a liquid di(4-aminocyclohexyl)methane mixture containing from 15 to 40% by weight and preferably from 18.5 to 23.5% by weight, of the trans, trans isomer. The invention resides in the use of an unsupported ruthenium dioxide catalyst under specific process conditions. During the hydrogenation reaction, a pressure of at least 2500 psi and a temperature of from 150.degree. to 210.degree. C. must be maintained.
Abstract: This invention relates to a process for the production of polyurethanes, particularly polyurethane foam moldings having a compact skin and a cellular core, using special tin activators.
Type:
Grant
Filed:
January 25, 1982
Date of Patent:
June 28, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Werner Rasshofer, Geza Avar, Hans-Albrecht Freitag, Gerhard Grogler, Richard Kopp
Abstract: Hydraulically coupled injection nozzles (5,28) and return nozzles (15,38) are used in an apparatus for producing a reaction mixture of fluid components forming foam or a solid material. These nozzles (5,15,28,38) comprise control pins (11,20,34,43) which are designed to be inserted into the openings (6,17,29,40) of the nozzles (5,15,28,38). The ratio between the distances which the control pins (11,20,34,43) travel outside and inside the orifices (6,17,29,40) is adjusted in such a way that, when the nozzles (5,15,28,38) are switched from "mixing" to "circulation" or vice versa, there is a time interval during which all the nozzles (5,15,28,38) are closed.
Type:
Grant
Filed:
May 11, 1981
Date of Patent:
June 21, 1983
Assignee:
Maschinenfabrik Hennecke GmbH
Inventors:
Ferdinand Proksa, Hans-Michael Sulzbach, Reiner Raffel, Ferdinand Althausen
Abstract: The invention is directed to new sulfur-containing diisocyanates in which a mercapto, sulfoxo or sulfone group joins two aromatic nuclei together or joins an aromatic nucleus to an aliphatic group and in which at least one of the aromatically bound isocyanate groups is in the ortho-position to the sulfur atom. The invention is also directed to a process for the preparation of these new sulfur-containing diisocyanates and to their use in the isocyanate polyaddition process for the production of polyurethanes.
Type:
Grant
Filed:
April 2, 1980
Date of Patent:
June 7, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jurgen Schwindt, Gerhard Grogler, Otto Ganster, Johannes Koster
Abstract: A process for the preparation of homogeneous and cellular polyurethane plastics by the reaction of(a) organic polyisocyanates;(b) compounds containing at least 2 Zerewitinoff-active hydrogen atoms and having molecular weights of from 400 to 10,000;(c) chain extenders, and, optionally, additional(d) short-chained compounds containing at least 2 Zerewitinoff-active hydrogen atoms and having a molar mass of from 32 to 400, as well as, optionally,(e) catalysts, blowing agents and other known additives,is described, which is characterized in that 1,4-3,6-dianhydro-hexites, preferably 1,4-3,6-dianhydro-D-sorbitol and/or 1,4-3,6-dianhydro-D-mannitol, optionally mixed with lower molecular weight compounds, preferably with polyols having a molecular weight of from 62 to 400, particularly preferably butane diol-1,4 are used as the chain extenders. The new chain extenders produce high quality elastomers and foams.
Type:
Grant
Filed:
March 11, 1982
Date of Patent:
May 10, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Holger Meyborg, Kuno Wagner, James M. Barnes, Herbert Salzburg
Abstract: The present invention is directed to a process for the production of N,O-disubstituted urethanes comprising reacting N-mono- or N,N'-disubstituted ureas or linear polyureas with aliphatic carbonic esters.
Type:
Grant
Filed:
September 28, 1981
Date of Patent:
April 26, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Hans-Josef Buysch, Heinrich Krimm, Wolfgang Richter
Abstract: Optionally-foamed intumescent compositions obtained by reacting(a) polyisocyanates with(b) phosphorus-containing condensation products having at least 2 hydroxyl groups and obtained by condensing primary or secondary monoamines and/or polyamines optionally containing OH-groups, carbonyl compounds and dialkyl phosphites, optionally followed by alkoxylation, and(c) more than bifunctional polyethers having an average OH-number of from 150 to 500 which have been obtained by the addition of alkylene oxides, of which from 50 to 100% by weight consist of ethylene oxide, with low molecular weight starters, and(d) cyanuric acid and/or cyanuric acid derivatives, and(e) optionally water and(f) optionally other organic compounds containing isocyanate-reactive hydrogen atoms,are used, for example, as cavity-filling, gap-sealing or coating materials.
Abstract: The invention relates to a process for the preparation of foamed or unfoamed polyurethanes by the reaction of compounds with molecular weights of 400 to 10,000 having at least two isocyanate-reactive hydrogen atoms with polyisocyanates in the presence of catalysts containing tertiary amino groups and optionally in the presence of chain-lengthening agents of molecular weight 32 to 400, foam stabilizers, water and/or organic blowing agents and optionally other auxiliary agents and additives, characterized in that the catalysts are morpholine derivatives of the general formula ##STR1## wherein X is an integer from 3 to 6 andR.sup.1 and R.sup.2 are identical or different and(a) represent a C.sub.1 -C.sub.6 -alkyl or C.sub.6 -C.sub.10 -cycloalkyl group or(b) form a heterocyclic ring containing 4-7 C-atoms, which heterocyclic ring may contain hetero groups in addition to the N-atom and wherein the additional hetero groups may be substituted by a C.sub.1 -C.sub.