Patents Represented by Attorney Richard A. Gaither

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  • Novel cyano compounds
    Patent number: 4079076
    Abstract: A novel conjugated diene bisfunctionalization process wherein a nitro group and a hydroxyl group in the form of an ester are introduced into the conjugated diene molecule by treatment of conjugated dienes with nitric acid in the presence of an acid anhydride. The novel compounds produced by this process and transformation products thereof, are useful as bactericides and fungicides and valuable organic synthesis intermediates, A novel procedure for the production of nitriles and .gamma.-acetoxytiglic aldehyde is disclosed.
    Type: Grant
    Filed: March 17, 1976
    Date of Patent: March 14, 1978
    Assignee: Hoffmann-La Roche, Inc.
    Inventor: Pius Anton Wehrli
  • Synthesis of biotin
    Patent number: 4062868
    Abstract: A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.
    Type: Grant
    Filed: February 23, 1977
    Date of Patent: December 13, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale Nicholas Confalone, Elizabeth Dianne Lollar, Giacomo Pizzolato, Milan Radoje Uskokovic
  • Hydroxybiotin
    Patent number: 4054740
    Abstract: This invention relates to a synthesis of biotin by the reduction of dehydrobiotin. The dehydrobiotin is prepared from 6-hydroxy-7-nitro-heptanoic acid methyl ester. Novel intermediates are also obtained by this synthesis.
    Type: Grant
    Filed: September 5, 1975
    Date of Patent: October 18, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: George Francis Field
  • Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters
    Patent number: 4054589
    Abstract: Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives useful as anti-tumor agents.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: October 18, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Bollag, Rudolf Ruegg, Gottlieb Ryser
  • Alkynyloxy-phenyl derivatives
    Patent number: 4051319
    Abstract: Alkynyl, benzyl or phenyl, ethers and esters which are ring substituted with an oxy or a thio aliphatic chain. These ethers and esters are useful in killing and preventing the proliferation of insects by upsetting their hormonal balance.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: September 27, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Madhukar Subraya Chodnekar, Albert Pfiffner, Norbert Rigassi, Ulrich Schwieter, Milos Suchy
  • 9[2-(1-Al koxy-ethyl)-5,5-dimethyl-cyclopent-1-en-1-yl]-3,7-dimethyl-nona-2,4,6,8-t etraen acid compounds
    Patent number: 4044051
    Abstract: 9-[2-(1-alkoxy-ethyl)-5,5-dimethyl-cyclopent-1-en-1-yl]-3,7-dimethyl-nona-2 ,4,6,8-tetraen acid compounds are disclosed which are useful for the topical or systemic treatment of dermatological disorders.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: August 23, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Bollag, Norbert Rigassi, Ulrich Schwieter
  • Synthesis of biotin
    Patent number: 4029647
    Abstract: Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and thiophene intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1976
    Date of Patent: June 14, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale Nicholas Confalone, Milan Radoje Uskokovic, Giacomo Pizzolato
  • Conversion of 4-lower alkyloxazole-5-carboxamide to 4-lower alkyl-5-cyanooxazoles
    Patent number: 4026901
    Abstract: A process is disclosed whereby 4-lower alkyl-5-cyanooxazoles, are obtained by vapor phase catalytic dehydration of 4-lower alkyloxazole-5-carboxamides.
    Type: Grant
    Filed: April 30, 1975
    Date of Patent: May 31, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David Llewellyn Coffen
  • Photochemical isomerization of vitamin A compounds
    Patent number: 4026778
    Abstract: A novel procedure for photochemical isomerization of vitamin A compounds or derivatives thereof in the absence of sensitizers is disclosed.
    Type: Grant
    Filed: November 3, 1975
    Date of Patent: May 31, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michel Lalonde, Hansjorg Stoller
  • Oxidation process using nickel peroxide oxidizing agents
    Patent number: 4026910
    Abstract: Preparation of a nickel peroxide oxidizing agent from nickel hydroxide and its use in oxidizing .alpha.,.beta.-unsaturated alcohols to the corresponding carbonyl compounds.
    Type: Grant
    Filed: July 23, 1975
    Date of Patent: May 31, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Roman Marbet
  • Antioxidant chroman compounds
    Patent number: 4026907
    Abstract: The (6-hydroxy-chroman-2-yl) acetic or carboxylic acid derivatives useful as antioxidants and a method for preparing these derivatives from hydroquinones and intermediates in this synthesis as well as the use of these derivatives as intermediates in the preparation of optically active alpha-tocopherol.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: May 31, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John William Scott, David Richard Parrish, Gabriel Saucy
  • 4-Benzyloxymethyl-5-[(1-pyrrolidinyl-carbonyl)-methyl]-1,3-cyclopent ylene-diacetate compounds
    Patent number: 4021446
    Abstract: A process for preparing (3,4,5,6)-4-benzyloxymethyl-hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-on e, a known intermediate for producing prostaglandins from 5,6-dimethylbicyclo[2.2.1]hept-5-en-2-endo-3-endo-dicarboxylic acid anhydride and intermediates in this process.
    Type: Grant
    Filed: October 9, 1975
    Date of Patent: May 3, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Albert Eduard Fischli, Michael Josef Klaus, Hans Johann Mayer, Alexander Eduard Wick
  • N-alkanoyl oxazole-carboxamide compounds
    Patent number: 4011234
    Abstract: 5-Cyano-4-methyl-oxazole-1,3 is prepared by pyrolyzing the reaction product of 5-carbamoyl-4-methyloxazole-1,3 and a lower alkanecarboxylic acid anhydride.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: March 8, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Hans Hoffmann-Paquotte
  • Preparation and use of magnesium acetylene complex
    Patent number: 4011271
    Abstract: Preparation of magnesium acetylene complex and its use in preparing ethynyl carbinols by reaction of said complex, alone or mixed with sodium acetylide, with an alpha, beta-unsaturated aldehyde or ketone.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: March 8, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: John Nicholson Gardner
  • 2,3,3A,6,7,7A-Hexahydro-thieno[3,2-b]pyridin-(4H)5-ones
    Patent number: 4009172
    Abstract: A novel procedure for the preparation of biotin, using cysteine as the starting material is disclosed. This process results in the obtention of pure d-biotin thus obviating the need for a chemical resolution. Novel intermediates are also disclosed.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: February 22, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico Baggiolini, Pasquale Nicholas Confalone, Giacomo Pizzolato, Milan Radoje Uskokovic
  • Nickel peroxide oxidizing agent
    Patent number: 4005031
    Abstract: Nickel peroxide on a fine, free-flowing carrier, which is formed by treating nickel oxide, deposited on the carrier, with an alkali hypohalite or alkali persulfate in an aqueous alkaline medium, and its use for selectively oxidizing an unsaturated alcohol to the corresponding carbonyl compound.
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: January 25, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Joseph Donald Surmatis
  • Intermediate compounds for the preparation of polyene aldehydes
    Patent number: 3997529
    Abstract: A novel process for the preparation of polyene aldehydes which employs as starting materials, substituted 2H pyrans. Novel substituted 2H pyrans and polyene intermediates are also disclosed.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: December 14, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Gary Lee Olson
  • Isomerizing cis-carotenoids to all-trans-carotenoids
    Patent number: 3989757
    Abstract: Cis-isomers of a carotenoid are isomerized to an all-trans-isomer of the carotenoid by heating the cis-isomers in water at above about 50.degree. C.
    Type: Grant
    Filed: April 29, 1974
    Date of Patent: November 2, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Joseph Donald Surmatis
  • Monoacetals of unsaturated aliphatic dialdehydes
    Patent number: 3989758
    Abstract: Mono acetals of unsaturated aliphatic dialdehydes having from 7 to 10 carbon atoms which are intermediates in the preparation of carotenoids.
    Type: Grant
    Filed: October 14, 1971
    Date of Patent: November 2, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rudolf Ruegg, Ulrich Schwieter
  • Synthesis of 2-methyl-3-buten-2-ol
    Patent number: 3988382
    Abstract: A process for producing 2-methyl-3-buten-2-ol by reacting isoprene with a hydrohalide and then with an aqueous base and then distilling the aqueous mixture in the presence of excess base to maintain the reaction mixture during distillation at a pH of at least 4.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: October 26, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Pius Anton Wehrli