Abstract: This invention relates to assays for an analyte in a liquid sample such as a body fluid. More particularly, the invention relates to a method and apparatus for the detection of a ligand in a body fluid such as urine or blood, which includes an immobilization zone for interfering agents in a sample.

Abstract: A pistol-shaped powder delivery device consolidates propellant pulse creation, powder storage, powder aerosolization and aerolsolized powdered delivery in a single device while providing dose, pattern and coverage control of the output spray. The single-hand-held, single-hand-operated device includes a housing having a handle portion that is selectively collapsed to generate a propellant pulse that is conveyed into and through powder stored in a reservoir mounted at an upward angle to the horizontal in a receptacle provided in the housing. Powder in the reservoir is caused to be aerosolized by the propellant pulse whereupon aerosolized powder exits the reservoir through an open end of, and elongate slots provided in the sidewall of, an elongate hollow member extending from an outlet in the receptacle through the stored powdered material into a head space in the reservoir. The outlet is connected a barrel portion for output of the aerosolized powder spray.

Abstract: A device for application of material to a surface, for example, biocompatible material to a tissue surface in a medical or clinical setting, is adapted to receive one or more biocompatible materials and one or more sources of pressurized medical gas, and to deliver these biocompatible materials via the medical gas(es) to a tissue surface or other surface. A regulation system controls flow of medical gas at a variety of pressures, and flow of biocompatible agent or agents, allowing agents to be sprayed or otherwise deployed onto a tissue surface. Switching apparatus operably connected to the regulation system directs a set of preset treatment positions allowing sequential application of biocompatible materials under various conditions in conjunction with an overall treatment protocol. The device can be used to apply a photoinitiating primer and polymeric sealant to a tissue surface, followed by light activation to form a polymer coating on the surface.

Abstract: An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practiced in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

Abstract: The present invention provides a novel apparatus for delivering a liquid or gel-like surgical material to a target site within a body cavity. The apparatus is characterized in part by an elongated structural member adapted for engagement with a conventional syringe and cannula assembly. In preferred embodiments of the present invention, devices of the invention further comprise a highly flexible applicator tip which permits application of the surgical material at variable delivery angles and even against gravity. Methods also are disclosed for applying the surgical material to the target site using. devices of the present invention.

Abstract: The present invention relates to surgical retractors and devices for stabilizing a predetermined area of the body during a surgical procedure, more particularly to surgical retractors and stabilizing devices used in connection with minimally invasive coronary artery bypass grafting surgical procedures, and more specifically to surgical retractors and stabilizing devices especially configured for use with each other for such surgical procedures wherein the retractor includes an external rail system which enables the surgeon to position a stabilization arm having first and second shaft segments on either of the arms or the rack segment of the retractor and also includes a connector which is spaced apart from the sled member and stabilization device to releasably control the movement and rotation of the stabilization device with respect to the stabilization arm and the rotation of the stabilization arm with respect to the retractor actuation of a single knob or actuator.

Abstract: An anastomosis device is provided for making connections between various conduits in the body of a patient. The device includes a first assembly that is threaded through the target conduit of the patient to a desired location. The device then pierces the wall of the target conduit and is then attached to an external assembly that is withdrawn through the wall of the target conduit to draw the desired connector and a graft conduit into the desired position along the wall of the target conduit. Thereafter, the first assembly is separated from the connector and graft conduit. In this invention, the connector may be a stent like device, staples or similar components to secure the graft conduit to the desired location along the wall of the target conduit.

Abstract: A fiber optic cable to be used with surgical instruments is provided wherein the cable is temporarily attached to the surgical instrument with which it is used, and mounted in an open design to allow illumination to a wider portion of the targeted area such that an entire surgical pocket may be illuminated, and the cables provided can be disposable without requiring permanent attachment to an instrument or development of surgical instruments permanently incorporating a light source by providing a plurality of guide members on the surgical instrument so the cable may be threaded through the guides and preferably engaged by at least one of the guides.

Abstract: An illuminated deep pelvic surgical retractor for illuminating a surgical site and retracting tissue adjacent thereto, the illuminated surgical retractor having a handle member interconnected at an obtuse angle to a first elongate section and a second elongate section that is releasably connected to the first elongate section and a portion of the second elongate section defining an illumination input end portion which is optically coupled to a light source so that the second elongate section is substantially illuminated, and, a shield member is positioned adjacent to the distal end portion of the first elongate section to aid in directing light selectively from the second elongate section to the desired tissue or organ.

Abstract: An apparatus for stabilizing a predetermined area on a heart or other organ of a patient to enable a surgical procedure, the apparatus comprising a bifurcated member having two elongated prongs and an elongated handle segment pivotably attached to the bifurcated member. The handle segment can be movably attached to a rib retractor or other surgical device so that a person is not required to hold the handle segment. The apparatus may further comprise an attachment or inlay to prevent lateral movement thereof when being used in the surgical procedure.

Abstract: The present invention relates to a low profile stabilizer that immobilizes tissue at a surgical site wherein the device includes a stabilizer having a base portion with elongate extending members that surround the sides of an aperture area and a removable end portion which is removable from the base portion and which surrounds the remaining side of the aperture area and wherein the stabilizer is preferably used in combination with a pair of flexible connectors that are threaded through the tissue adjacent to the aperture area to draw the tissue into contact with the aperture area of stabilizer and into contact with a pair of tab members extending from the bottom surface of the stabilizer such that the flow of blood through a blood vessel is occluded by tab members when the flexible connectors are releasably attached to the stabilizer.

Abstract: The present invention relates to surgical retractors having improved blades for use, on the retractor and devices for stabilizing a predetermined area of the body during a surgical procedure, more particularly to surgical retractors and stabilizing devices used in connection with minimally invasive coronary artery bypass grafting surgical procedures, and more specifically to surgical retractors and stabilizing devices especially configured for use with each other for such surgical procedures wherein the retractor includes a plurality of grooves on the bottom surface thereof and a plurality of blades having a member that is releasably received in the grooves and which also allows for the pivotal movement of the blades relative to the arms of the retractor and further including nesting blades having a third section which is generally linear and second sections which are preferably curved about 180 degrees to allow for the simplified insertion of the blades into the chest incision and the providing for the secur

Abstract: An illuminated retractor for creating a working space for dissecting instruments in support of a surgical procedure such as rectal examination or for the removal of polyps or hemorrhoids or other types of procedures which require the illumination and access to tissue in the rectal area of a patient, the illuminated retractor having a handle member pivotally connected at an obtuse angle to a first cylindrical and elongate section and a second elongate section that is releasably connected to the first elongate section and a portion of the second elongate section defining an illumination input end portion which is optically coupled to a light source so that the second elongate section is substantially illuminated, and, an operating channel extends along the lengthwise dimension of the first elongate section and the operating channel is illuminated by the second elongate section in use.

Abstract: A illuminated surgical retractor for illuminating a subcutaneous surgical field in the space between a vessel, such as the saphenous vein, and the subcutaneous tissue when the illuminated retractor is used to retract the subcutaneous tissue away from the superior surface of the vessel, the illuminated surgical retractor having a handle connected at an acute angle to a distal end of a first blade section, a second blade section that is connected, and substantially co-planer, to the first blade section, a distal end of the second blade section defining an illumination input end, a connector coupled to the illumination input end so that a source of illumination can be optically coupled, via the connector, to the illumination input end so that the second blade section is substantially illuminated, and, alternatively, a bent tip extending from the proximal end of the first blade section to aid in the required dissection of the intervening tissue.

Abstract: The present invention relates to a stabilizer that immobilizes tissue at a surgical site wherein the device includes a stabilizer having a base portion with elongate extending members that surround the sides of an aperture area and an end portion which is removable from the base portion and which surrounds the remaining side of the aperture area and wherein the stabilizer is preferably used in combination with a pair of flexible connectors that are threaded through the tissue adjacent to the aperture area to draw the tissue into contact with the aperture area of stabilizer and into contact with a pair of tab members extending from the bottom surface of the stabilizer such that the flow of blood through a blood vessel is occluded by tab members when the flexible connectors are releasably attached to the stabilizer.

Abstract: The present invention provides a novel apparatus for delivering a surgical material to a target site within a body cavity. The apparatus is characterized in part by a rod-like member to which a support carrier and a separator layer are attached at a distal end thereof for securing the surgical material therebetween, and an introducer tube for insertion into the body cavity. In certain preferred embodiments of the present invention, the rod-like member is configured for axial flexibility at a distal end thereof. Methods also are disclosed for applying the surgical material to the target site using the apparatus of the present invention.

Abstract: The present invention relates to surgical retractors and devices for stabilizing a predetermined area of the body during a surgical procedure, more particularly to surgical retractors and stabilizing devices used in connection with minimally invasive coronary artery bypass grafting surgical procedures, and more specifically to surgical retractors and stabilizing devices especially configured for use with each other for such surgical procedures wherein the retractor includes an external rail system which enables the surgeon to position a curved stabilization arm on either of the arms or the rack segment of the retractor and also includes a connector which releasably controls the rotation of the connector with respect to the retractor and the rotation of the stabilization arm with respect to the retractor as well as the rotational and sliding movement of a curved stabilization arm with respect to the connector upon actuation of a single knob or actuator.

Abstract: A illuminated surgical retractor for illuminating a subcutaneous surgical field in the space between a vessel, such as the saphenous vein, and the subcutaneous tissue when the illuminated retractor is used to retract the subcutaneous tissue away from the superior surface of the vessel, the illuminated surgical retractor having a handle connected at an acute angle to a distal end of a first blade section, a second blade section that is connected, and substantially co-planer, to the first blade section, a distal end of the second blade section defining an illumination input end, a connector coupled to the illumination input end so that a source of illumination can be optically coupled, via the connector, to the illumination input end so that the second blade section is substantially illuminated, and, alternatively, a bent tip extending from the proximal end of the first blade section to aid in the required dissection of the intervening tissue.

Abstract: The present invention relates to suture organizing device for use with surgical retractors and devices for stabilizing a predetermined area of the body during a surgical procedure, more particularly to a suture organizing device that is attachable to surgical retractors used in connection with minimally invasive coronary artery bypass grafting surgical procedures and heart valve procedures, and more specifically to a suture organizing device having a plurality of suture slots thereon for the releasable attachment of sutures thereto during a surgical procedure to enable the surgeon to retract tissue from the surgical field and wherein the suture organizing device is oriented to extend laterally of the outer surface of the arms of the surgical retractor.

Abstract: Featured is a pressure control regulator including a housing, a sealing member disposed within the housing, a flexible member and a biasing mechanism. The housing includes at least one inlet aperture and at least one outlet aperture, each inlet aperture being fluidly coupled to a first pressure source and each outlet aperture being fluidly coupled to a second pressure source, the first and second pressure sources being at different pressures. The flexible member extends between the sealing member outside surface and the housing inner surface so as to form a pressure boundary therebetween and to divide the housing interior into first and second compartments. The biasing mechanism, being responsive to pressure within the second compartment, acts on the sealing member so the sealing member is in one of an open position, when the second compartment is greater than a predetermined pressure value, or a closed position, when the second compartment pressure is at or below the predetermined pressure value.