Abstract: The present invention discloses methods of modulating the activity of Group I mGluRs using a defined class of benzamide compounds. In one embodiment, methods of modulating the activity of mGluR1 are provided. In another embodiment, methods of modulating the activity of mGluR5 are provided. In still another embodiment, methods of simultaneously modulating the activities of both mGluR1 and mGluR5 are provided. The present invention also provides methods of treating diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of benzamide compounds. The present invention further provides methods of preventing diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of compounds.

Abstract: Disclosed are scanning devices which measure and quantify optical properties within an object such as the absorption of light, refractive index, light scattering, fluorescence, and phosphorescence. Through the use of two rotating plane mirrors and two paraboloid mirrors, a laser light beam is made to traverse the object to be scanned wherein the beam is always parallel to the optical axis. The invention provides an improvement over previously reported scanning devices by virtue of increased speed and resolution. Two-dimensional projections gleaned by each scan of the object are reconstructed into a three-dimensional image through the use of various computer techniques.