Abstract: Aliphatic Nitrate esters having a sulfur or phosphorus atom .beta. or .gamma. to a nitrate group having efficacy as vasodilators are described. Preferred nitrate esters may be synthesized by nitration of a 3-bromo-1,2-propanediol, and subsequent reaction to yield the desired mono, di or tetra nitrate ester.
Type:
Grant
Filed:
June 4, 1996
Date of Patent:
September 15, 1998
Assignee:
Queen's University at Kingston
Inventors:
Gregory R. J. Thatcher, Brian M. Bennett