Patents Represented by Attorney Richard S. Parr

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  • Fibrinogen receptor antagonists
    Patent number: 5559127
    Abstract: Fibrinogen receptor antagonists of the formula: ##STR1## wherein A,B,D,E,Y are as defined in the specification, are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 24, 1996
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, John D. Prugh, Melissa S. Egbertson, Mark E. Duggan, William Hoffman, Wasyl Halezenko, Ben Askew
  • Fibrinogen receptor antagonists
    Patent number: 5525617
    Abstract: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: June 11, 1996
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Melissa S. Egbertson, Laura Birchenough, Laura Vassallo
  • Pyrrolidine thrombin inhibitors
    Patent number: 5510369
    Abstract: Compounds of the invention have the following structure: ##STR1## for example ##STR2## These compounds inhibit thrombin and associated thrombosis.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 23, 1996
    Assignee: Merck & Co., Inc.
    Inventors: William C. Lumma, Roger M. Freidinger, Stephen F. Brady, Philip E. Sanderson, Dong-Mei Feng, Terry A. Lyle, Kenneth J. Stauffer, Thomas J. Tucker, Joseph P. Vacca
  • Fibrinogen receptor antagonists
    Patent number: 5494921
    Abstract: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: February 27, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Melissa S. Egbertson, George D. Hartman, Laura A. Birchenough
  • Thrombin receptor radioligands
    Patent number: 5457177
    Abstract: The radioligands are six amino acid peptides having iodinated tyrosine at amino acid position six, including Ala-pFPhe-hArg-Cha-hArg-Tyr(I)-NH.sub.2, which mimic the activated form of the thrombin receptor protein. Thrombin receptor radioligands of the present invention are useful for screening for thrombin receptor antagonists.
    Type: Grant
    Filed: June 16, 1993
    Date of Patent: October 10, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Ruth F. Nutt, Dong-mei Feng, Robert J. Gould, Thomas M. Connolly
  • Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets
    Patent number: 5455243
    Abstract: Fibrinogen receptor antagonists of the formula: ##STR1## such as ##STR2## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: October 3, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Duggan, Melissa S. Egbertson, Nathan Ihle, George D. Hartman, Laura M. Turchi, William F. Hoffman
  • Fibrinogen receptor antagonists
    Patent number: 5451578
    Abstract: Compounds of the invention have the formula: ##STR1## which have fibrinogen receptor antagonist activity, including, for example, ##STR2##
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: September 19, 1995
    Assignee: Merck & Co., Inc.
    Inventors: David A. Claremon, Nigel Liverton, John J. Baldwin
  • Fibrinogen receptor antagonists
    Patent number: 5441952
    Abstract: Fibrinogen receptor antagonists of the ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets, for example ##STR2##
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: August 15, 1995
    Assignee: Merck & Co., Inc.
    Inventors: David A. Claremon, Nigel Liverton
  • Fibrinogen receptor antagonists
    Patent number: 5416099
    Abstract: Fibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the aggregation of blood platelets.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: May 16, 1995
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Melissa Egbertson, Laura M. Vassallo, Laura A. Birchenough
  • Fibrinogen receptor antagonists
    Patent number: 5397791
    Abstract: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: March 14, 1995
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, John D. Prugh, Wasyl Halczenko, Melissa Egbertson, Nathan Ihle
  • Fibrinogen receptor antagonists
    Patent number: 5389631
    Abstract: Fibrinogen receptor antagonists of the ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets wherein G is: ##STR2## for example, ##STR3##
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: February 14, 1995
    Assignee: Merck & Co., Inc.
    Inventors: David A. Claremon, Nigel Liverton
  • Beverage stabilizing system and process thereof
    Patent number: 5376396
    Abstract: A beverage stabilizing system which is a blend of gellan gum and carboxymethylcellulose. The blend provides a weak, stabilizing gel structure suitable for beverage products.
    Type: Grant
    Filed: April 27, 1993
    Date of Patent: December 27, 1994
    Assignee: Merck & Co., Inc.
    Inventor: Ross C. Clark
  • Fibrinogen receptor antagonists
    Patent number: 5374622
    Abstract: A fibrinogen receptor antagonist of the formulaAc-Cys-Asn-Pro-(L-AMF)-Gly-Asp-Cys-OHorAc-Cys-Asn-(DiMeTzl)-(L-AMF)-Gly-Asp-Cys-OH.
    Type: Grant
    Filed: January 28, 1993
    Date of Patent: December 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Ruth F. Nutt, Stephen F. Brady, Daniel F. Veber, Mark E. Duggan
  • Process for preparing low-fat fried food
    Patent number: 5372829
    Abstract: The present invention is a procedure for preparing cooked foods which involve the use of a gellan gum batter to coat a food substrate to impart qualities which are typically associated with fried foods, including crispness and juiciness. The coated food is then fried and frozen. Food products resulting from the procedure of the present invention contain low levels of fat and yet have the desirable qualities of fried foods.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: December 13, 1994
    Assignee: Merck & Co., Inc.
    Inventors: William F. Chalupa, George R. Sanderson
  • Sustained release tablets containing alginate
    Patent number: 5368862
    Abstract: Sustained release tablet comprising a microbially produced alginate-type polysaccharide and an active ingredient to be delivered in controlled fashion.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: November 29, 1994
    Assignee: Merck & Co., Inc.
    Inventor: George Colegrove
  • Carrier fluid for the suspension and delivery of water soluble polymers
    Patent number: 5362312
    Abstract: A liquid carrier fluid that is used as a carrier system to suspend and deliver water soluble polymers which act to adjust the rheological properties of the aqueous systems to which they are added.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Bryan Skaggs, Mike O'Brien, James M. Seheult, John M. Swazey
  • Fibrinogen receptor antagonists
    Patent number: 5358956
    Abstract: Novel fibrinogen receptor antagonists of the formula: ##STR1## are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: October 25, 1994
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Wasyl Halczenko
  • Composition and process for gelatin-free soft capsules
    Patent number: 5342626
    Abstract: The present invention relates to a polymer composition comprised of gellan, carrageenan and mannan gums and a process for producing flexible films for encapsulation comprising the gellan, carrageenan and mannan gum composition. The mannan gums include the galactomannans and the glucomannans. Advantageously, soft capsules of the above composition are produced using the novel process. The composition comprises a blend of a gellan gum: (carrageenan/mannan gum) wherein the gellan gum concentration ranges from about 0.1 to 50 weight percent and the ratio of carrageenan/locust bean gum ranges from 3:1 to 1:3. Additional reagents are added to this gum blend to form a film-forming polymer composition useful in the production of gelatin-free capsules or microcapsules.
    Type: Grant
    Filed: April 27, 1993
    Date of Patent: August 30, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Philip E. Winston, Jr., Frank J. Miskiel, Raymond C. Valli
  • Fibrinogen receptor antagonists
    Patent number: 5340798
    Abstract: The present invention comprises fibrinogen receptor antagonist compounds, compositions containing them and methods for using them to inhibit fibrinogen binding to blood platelets. Compounds of the invention have the following formula ##STR1## wherein Z is ##STR2## X is COOH, CH.sub.2 SH or SH; R.sup.1 is Y--R.sup.3, wherein R.sup.3 is alkyl and Y is amino, pyridinyl, pyrimidinyl or piperidinyl;R.sup.2 is H, alkyl, aryl, or arylalkyl; andR.sup.4 is alkyl, heteroalkyl, aryl or heteroaryl, wherein the aryl or heteroaryl group can be mono- or bi-cyclic.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: August 23, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Ruth F. Nutt, Daniel F. Veber
  • Protein for inhibiting collagen-stimulated platelet aggregation
    Patent number: 5340726
    Abstract: A protein which inhibits collagen-stimulated platelet aggregation. The protein has a molecular weight of approximately 17,000. A method of isolating the protein from Ornithodoros moubata and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
    Type: Grant
    Filed: August 16, 1993
    Date of Patent: August 23, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. Connolly, Paul M. Keller, Lloyd H. Waxman