Abstract: A device for delivering or withdrawing a substance from a patient includes a support member, a skin penetrating device and an advancing assembly for advancing the skin penetrating device to an operating position. The advancing assembly includes a supply spool for supporting a web having the skin penetrating devices attached thereon and a take up spool for receiving the web with the spent skin penetrating devices. The support has a bottom wall with at least one opening for exposing the skin penetrating device for penetrating the skin of a patient. In one embodiment the skin penetrating devices are micro needles having a length of about 50-2000 microns.

Abstract: The alignment-free solid laser of the invention is characterized in that, an orientation prism having three inner surfaces perpendicular to one another, a bottom of equilateral triangle or circle shape, a corner apex located on the axis of the active material is located in front of one end of the active material and is used as a total reflective mirror of the resonant cavity, the other end of the active material is coated with a transitive-reflective film and is used as an output mirror, such that a laser resonant cavity is formed. This alignment-free solid laser has a simple structure, strong ability of misalignment-resistance, high stability, improved beam quality and reduced damage. Besides, it is easy to be operated and is easy to be standardized and modularized. It can be extensively used in military, industrial processing, medical and scientific research fields.