Patents Represented by Attorney, Agent or Law Firm Richard T. Knauer.
  • Patent number: 6682704
    Abstract: The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite to one another into which the test elements are inserted in such a way that they lie directly adjacent to one another and the edges of adjacent supports abut one another. A further subject matter of the invention is a system which comprises a slide (14, 31) in addition to the magazine according to the invention which is used to push a layer of test elements along the guide grooves towards the opposite end of the layer to remove test elements from the magazine.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 27, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Gunter Bottwein, Reinhard Bär, Hans List, Friedrich Heid
  • Patent number: 6679852
    Abstract: System for withdrawing body fluid from a body part in particular the finger pad, comprising a compression unit that can be deformed when the body part is pressed against it and increases the internal pressure in a region of the body part, and a withdrawal device. Deformation of the compression unit partially converts the primary pressing movement into a secondary movement which leads to an increase in the internal pressure in a region of the body part. The invention also comprises a system for stimulating the outflow of body fluid using a deformable compression unit.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: January 20, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Guenther Schmelzeisen-Redeker, Frank Deck, Richard Forster, Thomas Weiss
  • Patent number: 6669910
    Abstract: System and process for isolating purified biological materials with a collecting unit which has collecting vessels that are accessible from above with a matrix unit in which matrix vessels are arranged in a holder as well as a closure unit which can be placed on the collecting unit to close the collecting vessel. In addition the invention also concerns a system having a collecting unit, a matrix unit, and a closure unit as well as a lysis unit and a waste unit. Moreover a new closure arrangement is disclosed which is suitable for closing vessels in which there is excess pressure.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: December 30, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Thomas Walter
  • Patent number: 6662439
    Abstract: A method of making a patterned laminate includes ablating through a portion of a metallic layer with a laser, to form a pattern in the metallic layer, where the metallic layer is on and in contact with an insulating substrate. The patterned laminate may be patterned to form electrodes, and can be formed into an electrochemical sensor strip.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: December 16, 2003
    Assignee: Roche Diagnostics Corporation
    Inventor: Raghbir Singh Bhullar
  • Patent number: 6613570
    Abstract: An aqueous control liquid is provided that contains glucose at a known concentration and cyclodextrin. A method is also provided that binds a wetting agent from a region of a test element that comes into contact with a sample. The method includes contacting the region with a control liquid that has a substance selected from the group of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m2/g to over 1000 m2/g. A method for controlling the function of a measuring system having test strips and a measuring instrument for the determination of glucose in liquid samples is provided that includes contacting the test strip with a control liquid containing glucose at a known concentration and at least one substance selected from the group consisting of cyclodextrins and cyclodextrin derivatives and detecting a signal caused by the glucose contained in the control liquid.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 2, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Wolfgang-Reinhold Knappe, Otto Gaa, Volker Zimmer, Joachim Hoenes, Bernd Hiller, Franz Wittmann, Beate Koschorreck
  • Patent number: 6602268
    Abstract: Blood lancet system for blood withdrawal for diagnostic purposes with a housing, a lancet holder movable in the housing for holding an exchangeable lancet, and a lancet drive for driving the pricking movement of the lancet holder with the lancet contained herein. The housing has a cap at the front end in pricking direction which can be removed in order to remove a used lancet from the lancet holder. The lancet and the housing cap are coupled, during the attachment of the housing cap, by a coupling mechanism comprising coupling elements matched to each other and enabling the extraction of the lancet from the lancet holder simultaneously with removing the housing cap.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: August 5, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Hans-Jurgen Kuhr, Richard Forster
  • Patent number: 6589260
    Abstract: System for withdrawing body fluid from a body part in particular the finger pad, comprising a compression unit that is deformed when the body part is pressed against it and increases the internal pressure in a region of the body part, and a withdrawal device. Deformation of the compression unit partially converts the primary pressing movement into a secondary movement which leads to an increase in the internal pressure in a region of the body part. The invention also comprises a system for stimulating the outflow of body fluid using a deformable compression unit.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: July 8, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Guenther Schmelzeisen-Redeker, Thomas Weiss, Frank Deck, Klaus Peter Ebert
  • Patent number: 6591126
    Abstract: The invention concerns a microdialysis system comprising a microdialysis probe (12) that can be inserted into organic tissue (10) and has a dialysis membrane (28) to separate a probe channel (18) filled with perfusion fluid from the tissue (10), a sensor cell (14) to determine the concentration of components and especially glucose in the perfusion fluid that is conveyed from the microdialysis probe (12) and a transport device (16) to convey the perfusion fluid through the probe channel (18) of the microdialysis probe (12) to the sensor cell (14).
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: July 8, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Josef Roeper, Michael Schoemaker, Christian Hoerauf
  • Patent number: 6537496
    Abstract: A flat-shaped functional overlay for at least one region of a flat-shaped flexible object which does not form a fold when the sandwich composed of the flexible object and overlay is bent towards the side on which the overlay is located is described. The overlay is composed of one or several flat-shaped overlays which are attached to the flexible object in such a way that a part of their surface can move freely relative to the surface of the object covered by this part in the direction of curvature produced when the object is bent. In addition diagnostic test strips are described which have such an overlay.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: March 25, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Wolfgang-Reinhold Knappe, Helmut Leininger, Ralf Steinbrueck, Franz Wittmann
  • Patent number: 6534017
    Abstract: The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite to one another into which the test elements are inserted in such a way that they lie directly adjacent to one another and the edges of adjacent supports abut one another. A further subject matter of the invention is a system which comprises a slide (14, 31) in addition to the magazine according to the invention which is used to push a layer of test elements along the guide grooves towards the opposite end of the layer to remove test elements from the magazine.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: March 18, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Gunter Bottwein, Reinhard Bär, Hans List, Friedrich Heid
  • Patent number: 6506575
    Abstract: The invention concerns an analytical element for determining the amount of an analyte in a liquid containing a sample application zone (1) and a detection zone (2) which are in liquid-transferring contact, the latter containing at least one enzyme and an indicator substance, the enzyme catalysing a reaction in which the analyte or a substance derived from the analyte participates and the indicator substance forming a signal when the analyte is present which signal correlates with the amount of analyte, and containing a liquid-permeable interference-reducing layer (3) in direct contact with the detection zone (2) arranged such that liquid does not reach the detection zone until it has passed through the interference-reducing layer, the interference-reducing layer containing at least one enzyme which participates in a reaction of the analyte to be determined or of a substance derived from the analyte, wherein the analyte or the substance derived from the analyte is converted enzymatically in the interference-re
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: January 14, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Wolfgang Reinhold Knappe, Rudolf Pachl, Otto Gaa
  • Patent number: 6497845
    Abstract: A storage container for holding analytical devices, the storage container being made of a rigid material and containing separate chambers in each of which at most one analytical device can be accommodated, wherein the chambers are in a regular geometric arrangement in relation to one another and each of the chambers has at least two opposite openings each sealed by a foil, wherein at least one of the chambers comprises a means for fixing the position of an analytical device in the chamber. In addition the invention concerns a system for storing analytical devices containing a storage container according to the invention and two or more analytical devices.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: December 24, 2002
    Assignee: Roche Diagnostics GmbH
    Inventor: Klaus-Dieter Sacherer
  • Patent number: 6475436
    Abstract: A method and a device for removing an analytic consumable product, in particular a test element, from a storage container having chambers which are sealed by foils from which the consumable product is pushed out by means of a plunger (7) can be optimized in that the magnitude of the thrusting force exercised by the plunger (7) during its forward motion can be controlled in dependence on the plunger (7) position.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: November 5, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Michael Schabbach, Karl Miltner, Thomas Klemm, Rolf Baumann, Meinrad Dilger
  • Patent number: 6455001
    Abstract: A skeleton-free functional layer of high precision which contains a wetting agent of formula I, II and/or III R1—CO—N(R2)—CH2—COOMe  (I) R1—CO—N(R2)—CH2—CH2—SO3Me  (II) HO2C—CH2—CH2—CH(NH—COR1)—CO2Me  (III) in which R1 is a long-chained aliphatic residue, R2 is an alkyl residue with 1 to 8 C atoms and Me represents hydrogen or a metal atom, a diagnostic test strip having this functional layer as well as processes for the production of these objects are described.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: September 24, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Wolfgang-Reinhold Knappe, Dan Mosoiu
  • Patent number: 6425863
    Abstract: Method for monitoring insulin medication in which blood sugar values are determined before and after a meal. The difference between these measured values is plotted against a quotient calculated from the bread units ingested during the meal and the insulin units used to compensate for these bread units. Displaying many such points on a graph provides criteria for improving the insulin medication.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: July 30, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Karl Werner, Peter Blasberg, Wilfried Muller
  • Patent number: 6419661
    Abstract: Device for withdrawing Blood for Diagnostic Purposes. A lancet holder (8) for holding a lancet (7) and a lancet drive (12) having a loadable elastic drive spring (15) are provided within an elongated housing (2). The relaxing motion of the drive spring (15) is converted into a puncturing motion, after release of a locking device, to move the lancet (7), held by the lancet holder (8), at high speed in the puncturing direction until its tip exists out of an exit opening (5) of the housing (2). An improved handling and simultaneous minimization of pain is achieved by providing a two-sided rotary/translatory transmission (25) in the housing (2), wherein a) the input side (24) of the rotary/translatory transmission (25) transforms the motion of a loading button (17), protruding out of the rear end (16) of the housing.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: July 16, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans Jürgen Kuhr, Richard Forster
  • Patent number: 6409740
    Abstract: Blood lancet for withdrawing blood for diagnostic purposes. It has a housing with an outlet opening for the tip of a lancet, and a lancet drive with a drive rotor driven in a sense of rotation by a drive spring. The drive rotor converts the relaxation movement of the drive spring to a pricking movement, moving the lancet with high speed in pricking direction, until the tip protrudes from the outlet opening. The drive rotor has a pressure surface directed radially outwardly and running around the rotation axis with varying center distance. The pressure surface has a vertex with maximum center distance, and a propelling section, following the vertex against the sense of rotation and having a center distance decreasing against the sense of rotation. The drive spring effects a pressure on the propelling section of the pressure surface, thus driving the drive rotor in sense of rotation, whereas the drive rotor is coupled to the lancet holder.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: June 25, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans-Jurgen Kuhr, Herbert Argauer
  • Patent number: D448294
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: September 25, 2001
    Assignee: Roche Diagnostics Corporation
    Inventors: Hartmut Alscher, Joachim Kohl, Klaus-Dieter Sacherer
  • Patent number: D471280
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Roche Diagnostics Corporation
    Inventor: Thomas Jaeck
  • Patent number: D487594
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: March 16, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Hartmut Alscher, Joachim Kohl, Klaus-Dieter Sacherer