Patents Represented by Attorney Richard W. Bork

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  • Preparation comprising insulin, nicotinamide and an amino acid
    Patent number: 8324157
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: December 4, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Acylated GLP-1 compounds
    Patent number: 8129343
    Abstract: Protracted GLP-1 compounds and therapeutic uses thereof.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: March 6, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Paw Bloch, Thomas Kruse Hansen
  • Derivatives of GLP-1 analogs
    Patent number: 8097698
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: January 17, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Soren Erik Bjorn, Freddy Zimmerdahl Pedersen, Kjeld Madsen
  • Protracted exendin-4 compounds
    Patent number: 8030273
    Abstract: Novel protracted exendin-4 compounds and therapeutic uses thereof.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: October 4, 2011
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Thomas Kruse Hansen
  • Plasma protein affinity tags
    Patent number: 7897560
    Abstract: Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: March 1, 2011
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dorwald, Bernd Peschke
  • Protracted GLP-1 compounds
    Patent number: 7893017
    Abstract: Novel protracted GLP-1 compounds and therapeutic uses thereof.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: February 22, 2011
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Thomas Kruse Hansen
  • Peptide derivatives
    Patent number: 7576059
    Abstract: A pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent peptide hormone or an analogue thereof, said lipophilic substituent having from 8 to 40 carbon atoms, has a protracted profile of action.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: August 18, 2009
    Assignee: Novo Nordisk A/S
    Inventors: Ib Jonassen, Svend Havelund, Per Hertz Hansen, Peter Kurtzhals, John B. Halstrøm
  • Peptide purification by means of metal ion affinity chromatography
    Patent number: 7456276
    Abstract: A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: November 25, 2008
    Assignees: Novo Nordisk A/S, Monash University
    Inventors: Thorkild Christensen, William Milton Thomas Hearn, Leone Spiccia, Wei Jiang, Therese Jane Mooney, Bimbil Graham
  • Methods and preparations for curing clinically ill patients
    Patent number: 7446091
    Abstract: This invention relates to a life saving medicament for critically ill patients and a method of treatment. The composition is a pharmaceutically effective amount of a blood glucose regulator which is used to control the blood glucose level.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: November 4, 2008
    Assignee: Novo Nordisk A/S
    Inventor: Greta Van Den Berghe
  • Formulations of insulin
    Patent number: 7387996
    Abstract: Stable insulin formulations can be prepared by mixing a monomeric insulin and a soluble acylated insulin analog.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: June 17, 2008
    Assignee: Novo Nordisk A/S
    Inventor: Liselotte Langkjaer
  • Method for producing acylated peptides
    Patent number: 7273921
    Abstract: The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: September 25, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Dorte Lunoe Dunweber, Inge Holm Jensen, Louis Brammer Hansen
  • Derivatives of GLP-1 analogs
    Patent number: 7235627
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: June 26, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudson, Per Olaf Huusfeldt, Per Franklin Nielsen
  • Purification process comprising microfiltration at elevated temperatures
    Patent number: 7229554
    Abstract: Process for microfiltration at elevated temperature.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: June 12, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Lars Hojlund Christensen, Torben Kjaersgaard Nielsen
  • Insulin derivatives
    Patent number: 7229964
    Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the ?-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: June 12, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm
  • Extendin derivatives
    Patent number: 7226990
    Abstract: The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid residue, which is not the N-terminal or C-terminal amino acid residue of the derivative.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: June 5, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Kjeld Madsen
  • Synchronization of the cytoplasmatic and the nuclear maturation of oocytes
    Patent number: 7192768
    Abstract: The present invention relates to a method for in vitro maturation of oocytes comprising the steps of: (a) culturing one or more GV oocytes in a culture medium, the culture medium comprising a nuclear maturation inhibiting substance and comprising one or more gonadotropins and/or one or more growth factors, the culturing taking place for a time period sufficient for cytoplasmatic maturation to occur; (b) washing the GV oocytes of step (a) to remove the nuclear maturation inhibiting substance; (c) culturing the washed oocytes of step (b) in a culture medium comprising one or more gonadotropins and/or one or more growth factors and/or MAS for a time period sufficient for nuclear maturation. The invention also relates to an oocyte culture medium comprising a nuclear maturation inhibiting substance and comprising one or more gonadotropins and/or one or more growth factors.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: March 20, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Claus Yding Andersen, Anne Grete Byskov
  • Method for preparing a compound with growth hormone releasing properties
    Patent number: 6784158
    Abstract: A method for preparing a compound of formula I or a salt thereof is disclosed.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: August 31, 2004
    Assignee: Novo Nordisk A/S
    Inventor: Claus Ulrich Jessen
  • Injection needle
    Patent number: 6605067
    Abstract: An injection needle unit for use on a syringe by patient administrated injections, comprising a hub fitting on the syringe which hub carries a needle having a cross section diameter less than 0,320, the needle being made from a super elastic material defined as a material which can obtain recovered elongation of more than 2% without having permanent deformation in the material. The injection needle can be forced away from its original linear shape and the force by which it seeks to return to this linear shape is used for automatic insertion of the needle.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: August 12, 2003
    Assignee: Novo Nordisk A/S
    Inventor: André Larsen