Patents Represented by Attorney Richard W. Winchell
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Patent number: 4230738Abstract: A process is provided for the preparation of a textured protein concentrate which has improved meat-like texture and bland flavor. The basic process utilized includes aqueous solvent extraction of water soluble constituents from protein extrudate containing such constituents, and the present invention provides an improvement in said basic process which comprises utilizing a protein extrudate having a density of between about 85 to 150 grams per liter on a dry weight basis and extraction at pH between about 4.4 and 6.0. Using an aqueous extraction at a pH between about 5.0 and 6.0, the textured protein concentrate has a texture similar to the tender lean portions of beef, pork, poultry or shellfish. Using an aqueous extraction at a pH between about 4.4 and 5.0, the textured protein concentrate has a texture similar to fish.Type: GrantFiled: October 22, 1976Date of Patent: October 28, 1980Assignee: Miles Laboratories, Inc.Inventors: Michael Shemer, Richard E. McDonald, Anthony H. Chen
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Patent number: 4188399Abstract: Heat coagulable viscous protein product is prepared from oleaginous seed materials by forming an aqueous slurry thereof having a pH of about 5.1 to about 5.9, separating the liquid from the solids portion of said slurry, and recovering the protein product from said separated liquid.Type: GrantFiled: December 23, 1974Date of Patent: February 12, 1980Assignee: Miles Laboratories, Inc.Inventor: Michael Shemer
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Patent number: 4181657Abstract: Novel compounds having the structural formula ##STR1## wherein R.sub.1 is hydrogen, i-propyl, phenyl or a substituted phenyl having the structure ##STR2## wherein R.sub.2 is halogen, methoxy, lower alkyl, nitro, trifluoromethyl, acetamido, or sulfonamido and their acid addition salts, are useful for treatment of cardiovascular disorders such as cardiac arrhythmia, hypertension, and angina pectoris. Methods for preparation and use of these compounds are described.Type: GrantFiled: July 14, 1978Date of Patent: January 1, 1980Assignee: Miles Laboratories, Inc.Inventors: Herbert J. Havera, Horacio Vidrio, Richard D. Johnson
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Patent number: 4163025Abstract: A process is provided for preparing benzylamine and dibenzylamine by passing benzonitrile and hydrogen counter-currently through a catalyst bed under suitable conditions of temperature and pressure to hydrogenate the benzonitrile and thereby produce the desired reaction product.Type: GrantFiled: January 16, 1975Date of Patent: July 31, 1979Assignee: Miles Laboratories, Inc.Inventors: Richard A. Plunkett, Jerry L. Neff, Timothy A. Bemish
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Patent number: 4149017Abstract: Useful intermediates in the preparation of bicycloalkyl analogues or derivatives of prostaglandins are represented by the formula ##STR1## wherein: X is an iodo or bromo radical;A is an acid-labile hydroxyl-protecting group;G is an integer having a value of from 0 to 10; andB is selected for the class of bicycloalkyl radicals of the formula: ##STR2## WHERE M AND P ARE INTEGERS HAVING A VALUE OF FROM 1 TO 4; N IS AN INTEGER HAVING A VALUE OF FROM 0 TO 4 SUCH THAT THE SUM OF M, N AND P IS GREATER THAN OR EQUAL TO 3 AND THE POINT OF ATTACHMENT OF THE ALKYL CHAIN (CH.sub.2).sub.g to the bicycloalkyl radical is in the (CH.sub.2).sub.m bridge or in the bridgehead position.Type: GrantFiled: July 25, 1977Date of Patent: April 10, 1979Assignee: Miles Laboratories, Inc.Inventors: Warren D. Woessner, Charles J. Sih, Harold C. Kluender, Henry C. Arndt, William G. Biddlecom
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Patent number: 4141999Abstract: An improved bacon-like meat analog is provided having a novel simulated fatty portion which is intended when fried to ripple or crinkle and have a juicy, fatty mouthfeel similar to the fatty portions of bacon. The analog has alternate layers simulating the lean and fat portions of bacon. The improvement comprises including layers simulating the fat portions produced by cooking a composition mixture consisting essentially of 3 to 7 percent albumen, 25 to 40 percent water, 0 to 6 percent vegetable protein, 52 to 65 percent vegetable oil, 0.05 to 0.60 percent vegetable gums and 4 to 10 percent flavors and seasonings.Type: GrantFiled: October 7, 1977Date of Patent: February 27, 1979Assignee: Miles Laboratories, Inc.Inventor: George M. Lolas
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Patent number: 4133897Abstract: A juicy, self-basting sausage-like food product is prepared by the following steps: (a) forming a protein binder slurry containing 20 to 32% water, 3 to 8% albumen, 0.5 to 4% caseinate and 0 to 2.5% vegetable protein isolate; (b) adding 3 to 15% vegetable oil to the slurry; (c) vigorously agitating the oil-containing slurry to form a protein-oil emulsion; (d) forming a textured protein mixture containing 30 to 40% cooked gluten, 1 to 14% textured vegetable protein and 0 to 4% water; (e) blending the protein-oil emulsion and the textured protein mixture together; (f) blending 3 to 15% vegetable oil with the combined mixture; (g) shaping the resulting mixture to a desired form; and (h) heating the shaped mixture to set the protein in a stable, physical form, said percents being weight percent based on the total weight of the product.Type: GrantFiled: October 28, 1977Date of Patent: January 9, 1979Assignee: Miles Laboratories, Inc.Inventors: John R. Flanyak, Herbie R. Norton
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Patent number: 4115438Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.Type: GrantFiled: July 21, 1977Date of Patent: September 19, 1978Assignee: Miles Laboratories, Inc.Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
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Patent number: 4115453Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.Type: GrantFiled: July 22, 1977Date of Patent: September 19, 1978Assignee: Miles Laboratories, Inc.Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
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Patent number: 4108847Abstract: A bland, protein enriched product is produced by forming an aqueous slurry of a crude grain gluten which contains oil and water soluble constituents at a pH between about 6.5 and 10.0, agitating the slurry to form an oil-water emulsion, separating the gluten solids from the emulsion which contains oil and water-soluble constituents; and drying the separated gluten product.Type: GrantFiled: September 9, 1977Date of Patent: August 22, 1978Assignee: Miles Laboratories, Inc.Inventors: Howard Lee Creinin, Michael Shemer
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Patent number: 4108892Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E, and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.Type: GrantFiled: July 22, 1977Date of Patent: August 22, 1978Assignee: Miles Laboratories, Inc.Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
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Patent number: 4098823Abstract: Novel monospiroalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacalogical properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.Type: GrantFiled: January 10, 1977Date of Patent: July 4, 1978Assignee: Miles Laboratories, Inc.Inventors: Henry Clifford Arndt, William Gerard Biddlecom, Warren Dexter Woessner
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Patent number: 4097479Abstract: Synthesis of 5-substituted tetrazoles via reaction of an organic nitrile with azide anion is improved by performing the reaction in an amine as solvent and in the presence of an acid-addition salt of the amine as catalyst.Type: GrantFiled: March 11, 1977Date of Patent: June 27, 1978Assignee: Miles Laboratories, Inc.Inventor: Theodore J. Leipzig
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Patent number: 4074063Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.Type: GrantFiled: February 11, 1976Date of Patent: February 14, 1978Assignee: Miles Laboratories, Inc.Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
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Patent number: 4066834Abstract: Analogues of prostaglandins A, E, and F in which the C.sub.13 -C.sub.20 chain of the natural prostaglandins is replaced by a cycloalkenyl or a hydroxycycloalkenyl moiety such that vinylene radical and the hydroxyl group of the ring respectively retain their natural sequential positions at C.sub.13 -C.sub.14 and C.sub.15, inhibit aggregation of platelets in vitro and exhibit useful cardiovascular activity in vivo.Type: GrantFiled: October 20, 1975Date of Patent: January 3, 1978Assignee: Miles Laboratories, Inc.Inventors: Warren Dexter Woessner, William Gerard Biddlecom, Henry Clifford Arndt, George Peter Peruzzotti, Charles John Sih
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Patent number: 4061760Abstract: Compounds having the generic structure, ##STR1## and their nontoxic, pharmacologically acceptable salts are useful in the chemotherapy of arrhythmias in individuals for whom such therapy is indicated. In the preceding structural formula: R.sup.1 is a 2-pyridyl, 3-pyridyl, or 4-pyridyl radical; n is an integer of the set 1-3; and R.sup.2 is a hydrogen atom, a hydroxyl, or an equivalent alkoxyl group having from 1 to 3 carbon atoms.Type: GrantFiled: October 4, 1976Date of Patent: December 6, 1977Assignee: Miles Laboratories, Inc.Inventors: Herbert John Havera, Wallace Glenn Strycker
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Patent number: 4015462Abstract: Devices and methods are provided for determining specific gravity or osmolality of liquids. The preferred devices comprise a carrier matrix incorporated with microcapsules having osmotically fragile, semipermeable polymeric membrane walls encapsulating therein a solute and a coloring substance. In use, the test device is contacted with the liquid to be tested, and color change on the carrier matrix is observed as a measure of the specific gravity or osmolality of the liquid.Type: GrantFiled: January 8, 1976Date of Patent: April 5, 1977Assignee: Miles Laboratories, Inc.Inventors: Jerome Greyson, Sisto Nicholas Stiso
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Patent number: 3986833Abstract: Improved test compositions, devices and methods are provided for detecting peroxidatively active substances in body fluids, excreta and the like. In the type of test compositions including an indicator capable of being oxidized in the presence of a peroxidatively active substance to provide a color change, an oxidizing agent effective to oxidize said indicator, and a potentiating agent, the improvement comprises the use as said potentiating agent of an acid salt or adduct of a compound selected from the class of compounds of the general formula ##SPC1##Wherein R.sub.1 is hydrogen, lower alkyl, hydroxy or thiophenyl; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, carboxy, lower alkyl or lower alkoxy; and R.sub.5 is hydrogen or lower alkyl.Type: GrantFiled: September 8, 1975Date of Patent: October 19, 1976Assignee: Miles Laboratories, Inc.Inventors: Raymond L. Mast, Charles Tak Wai Lam
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Patent number: 3974134Abstract: Protein can be isolated and purified from polycarboxylic acid-protein precipitates, obtained by mixing an aqueous cheese whey solution with a polycarboxylic acid selected from the class consisting of polyacrylic acid, hydrolyzed ethylene maleic anhydride copolymers and hydrolyzed methyl vinyl ether-maleic anhydride copolymers, by forming an aqueous solution of said precipitate having a pH between about 6 to about 9, adding to said solution a substance selected from the class consisting of calcium salts, magnesium salts, barium salts and aluminum salts to form a precipitate with the polycarboxylic acid present and separating the purified protein solution from the resulting precipitate.Type: GrantFiled: January 13, 1975Date of Patent: August 10, 1976Assignee: Miles Laboratories, Inc.Inventor: Moshe Sternberg
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Patent number: 3956514Abstract: Wet spun proteinaceous filaments are prepared from pulverized, functional defatted leguminous materials having a protein content of about 45 to about 55 percent, by forming an aqueous slurry thereof to extract proteins and carbohydrates, precipitating the protein onto and into the insoluble portion of the leguminous material, separating the solids from the liquid portion of the slurry, forming an aqueous alkaline spinning dope with the separated solids and forcing the spinning dope through a spinneret into an acid and salt coagulating bath to form proteinaceous filaments.Type: GrantFiled: September 25, 1974Date of Patent: May 11, 1976Assignee: Miles Laboratories, Inc.Inventors: Moshe M. Sternberg, Chong Yol Kim