Abstract: A prosthetic part for use as an orthopaedic implant has a cast metal base member and a tissue ingrowth surface spaced outwardly therefrom. The tissue ingrowth surface is in the form of a cast metal lattice element which covers at least a part of the outer surface of the base member. The cast metal lattice element is cast simultaneously and integrally with the base member from the same metal. This metal may be any well known castable material for orthopaedic implants such as Vitallium or titanium. The lattice element is in the form of a grid-like mesh which includes spaced members cast integrally with the wire mesh and the base member to space the lattice element a predetermined distance above the prosthesis surface. An investment casting technique wherein a meltable material is coated with a ceramic casting shell is utilized to produce the integrally cast orthopaedic implant and tissue ingrowth surface.

Abstract: Hypoglycemic thiazolidine-2,4-derivatives ##STR1## wherein the dotted line represents a bond or no bond; V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N-- or S;W is CH.sub.2, CHOH, CO, C.dbd.NOR or --CH.dbd.CH--;X is S, O, NR.sup.1, --CH.dbd.N-- or --N.dbd.CH--;Y is CH or N;Z is hydrogen, (C.sub.1 -C.sub.7)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, phenyl, naphtyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C.sub.1 -C.sub.3)alkyl, trifluoromethyl, (C.sub.1 -C.sub.3)alkoxy, fluoro, chloro or bromo;Z.sup.1 is hydrogen or (C.sub.1 -C.sub.3)alkyl;R is hydrogen or methyl; andn is 1, 2 or 3;a pharamceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains basic nitrogen.