Abstract: The disclosure herein provides a compound of formula 1. The disclosure also provides a method of synthesizing the compound of formula 1. The compound of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof may be formulated as pharmaceutical composition. The pharmaceutical composition of compound of formula 1 or the final compound may be formulated for non-invasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications. The compound may also be offered as a kit.

Abstract: An eco friendly radiation cross-linked composition is described that demonstrates excellent resistance to fire and high temperature along with good mechanical properties. The composition which is based on a blend of EVA with a LLDPE, is free of monomer such as vinyl co-agent for radiation cross-linking. The halogen free flame retardant composition is a mixture of 20 to 90% by weight of magnesium hydroxide (powder A) and 90% to 20% of powder B. Preferably the powder B is a double salt of magnesium carbonate and calcium carbonate and the magnesium hydroxide has a specific surface treatment. In addition, 0.5 to 5 parts of flame retardancy agents are selected from talc, zinc borate or molybdate derivative. The chemicals used here reduce toxicity in the environment and do not release toxic chemicals to air and soil during fire. The flame retardant cross-linked polyolefin composition is particularly useful for insulating wires and cables.

Abstract: A simple, room-temperature method of producing zinc oxide nanoparticles was established by reacting zinc nitrate hexahydrate and cyclohexylamine (CHA) in either aqueous or EtOHic medium. Particles of polyhedra morphology were obtained for zinc oxide, prepared in EtOH (ZnOE), while an irregular spherical morphology, mixed with some chunky particles forzinc oxide prepared in water (ZnOW). The results indicate that there are significant morphological differences between ZnOE and ZnOW. ZnOE showed a regular polyhedral shape, while spherical and chunky particles were observed for ZnOW. The morphology was crucial in enhancing the cyanide ion photocatalytic degradation efficiency of ZnOE by a factor of 1.5 in comparison to the efficiency of ZnOW at equivalent loading of 0.02 ZnO nanoparticles wt %. Increasing the loading wt % of ZnOE from 0.01 to 0.07 led to an increase in the photocatalytic degradation efficiency from 67% to 90% after 45 minutes and a doubling of the first-order rate constant (k).

Abstract: A self-closing resealable can end for a beverage container that opens the top of the beverage container through downward pressure that causes a gate to move downward relative to the top panel. The gate is retained by a resilient member and when the downward pressure ceases, the gate is moved into proximity with the top panel. Pressure from the carbonation presses the gate against a lip and the gate bends to form an enhanced seal. Other variations are disclosed.

Abstract: An adsorbent composition and method of cleaning the industrial waste water using the composite is described. The method for removing heavy metals from contaminated water is done by mixing contaminated water having a concentration of one or more heavy metals with an adsorbent composite comprising granules of a mixture of 50.363 wt % kaolin clay, a 4.477 wt % roasted date pits powder, a 5.54 wt % silica powder a 14.99 wt % magnesite powder and a 24.623 wt % water. After reacting the contaminated water and adsorbent composite together for a specific time the water is filtered and was found to contain reduced amount of heavy metals. The cleaned water can further be used for industrial cooling systems or watering gardens.

Abstract: The present disclosure describes using the naturally present dissolved chemicals as precipitants from local water sources to form an adsorbent and a process of purifying the water using natural resources. The adsorbent may be processed at the right pH and temperature to purify and remove heavy metals from waste water. Once the heavy metals are removed the concentration of the heavy metals are estimated in the reusable water. The local authority acceptable level heavy metal containing reusable water is reclaimed for non-human consumption. This disclosure enables to conserve water and provide a cheap and an effective method to decontaminate industrial waste water.

Abstract: Sea water is not suitable for human consumption. Naturally present dissolved chemicals in sea water make it inconsumable. The precipitants and dissolved chemicals need to be separated from water to make it consumable. A combination of aeration system, filtration system, crystallizer, hydrophobic membrane carrying filter and pressure retarded osmosis system are used in various combination to desalinate the sea water. Pressure retarded osmosis process is also used to produce pressurized diluted brine which is further decompressed to by the turbine and used by the generators to produce electricity. Various heat exchange apparatus are used for energy conservation and efficient processing of water in a feasible way. The disclosure enables to purify water and provide an economical means for producing electricity.

Abstract: Water from underground and other sources is brackish and not suitable for human consumption. Naturally present dissolved chemicals in water make it brackish. The precipitants and dissolved chemicals need to be separated from water to make it consumable. A combination of aeration systems, filtration systems, crystallizers and hydrophobic membrane carrying filter are used to desalinate the brackish water. Pressure retarded osmosis process using an apparatus is also used to further purify water. Various heat exchange apparatus are used for energy conservation and efficient processing of water in a feasible way. The disclosure enables to purify water and provide a useful technology to eradicate water scarcity.

Abstract: The present disclosure describes using the naturally present dissolved chemicals as precipitants from local water sources to form an adsorbent. The adsorbent may be collected and used at the right pH and temperature to purify and remove heavy metals from waste water. Once the heavy metals are removed the concentration of the heavy metals are estimated in the reusable water. The local authority acceptable level heavy metal containing reusable water is reclaimed for non-human consumption. This disclosure enables to conserve water and provide a cheap and an effective method to decontaminate industrial waste water.

Abstract: An adsorbent composition and method of using the adsorbent composite is described. The method for removing heavy metals from contaminated water is done by mixing contaminated water having a concentration of one or more heavy metals with an adsorbent composite comprising granules of a mixture of 50.363 wt % kaolin clay, a 4.477 wt % roasted date pits powder, a 5.54 wt % silica powder a 14.99 wt % magnesite powder and a 24.623 wt % water. After reacting the contaminated water and adsorbent composite together for a specific time the water is filtered and was found to contain reduced amount of heavy metals. The cleaned water can further be used for industrial cooling systems or watering gardens.

Abstract: Water from underground and other sources of water are brackish and not suitable for human consumption. Naturally present dissolved chemicals in water make it brackish. The precipitants and dissolved chemicals need to be separated from water to make it consumable. A combination of aeration systems, filtration systems, crystallizers and hydrophobic membrane carrying filter are used to desalinate the brackish water. Solar energy and ceramic filters are used as add on to existing technology. Various heat exchange apparatus are used for energy conservation and efficient processing of water in a feasible way. The disclosure enables to purify water and provide a useful technology to eradicate water scarcity.

Abstract: Ruthenium/activated charcoal (Ru/AC) treated with synthesized nano-ZnO (n-ZnO) is used for the first time as a novel composite catalyst in one-step self-condensation of acetone (DMK) to methyl isobutyl ketone in the gas phase. The DMK self-condensation was performed under atmospheric pressure, in a tubular glass fixed-bed microreactor, under DMK and H2 continuous flow at temperature in the range of 523 to 648 K. Addition of n-ZnO to Ru/AC resulted in a pronounced increase in the degree of dispersion of Ru and in the acidic/basic sites concentration ratio. For the one-step synthesis of MIBK at 623 K, the composite catalyst with 2.5 wt % Ru loading was an active and selective bi-functional composite catalyst with balanced acid/base and hydrogenation properties. At 523 K, isopropyl alcohol, product of DMK-direct hydrogenation, was produced in high selectivity for instantly investigated composite catalyst.

Abstract: A low-pressure one-step gas-phase process for the production and recovery of methyl isobutyl ketone (MIBK) is disclosed. One-step gas-phase synthesis of MIBK from acetone and hydrogen over nano-Pd/nano-ZnCr2O4 catalyst at atmospheric pressure is used as an example. The said process is designed to recover the additional heat associated with the reactor effluent via heating acetone feed and recycle (mixed acetone) before entering the reactor. A compressor is introduced to the gas-phase process to increase slightly the reactor effluent pressure before this effluent is cooled and fed to a flash drum. The compressed reactor effluent is used to preheat hydrogen feed and recycle (mixed hydrogen) before entering the reactor. The separation scheme of low-pressure one-step gas-phase process comprises of several distillation columns used for MIBK separation and purification.

Abstract: The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used for diagnostic and treatment purposes of various diseases. In particular, the diseases may involve the mechanism of degradation of extracellular matrix by MMP's during cell proliferation cycle. Suppression of MMP activity seems to arrest tumor growth during cancer progression. MMP oligopeptides were used as vaccines to treat mice having murine melanoma B16FO induced tumor. There was a significant drop in tumor weight and size for the group of mice that were immunized with MMP oligopeptide.

Abstract: The present invention relates to synthetic oligopeptides that exhibit inhibitory activity towards cancer invasion and metastasis. The peptides of the invention comprise PRKPKWDK (SEQ ID:2) peptide corresponding to amino acids of 85 to 92 of the matrix metalloproteinase (MMP-2), and fragments, analogs and homologs. The invention also relates to the uses of such peptides as inhibitory of human cancer invasion and metastasis and further to their therapeutic use in preventing and treating other pathological conditions related to the degradation of extracellular matrix by MMPs.

Abstract: The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used for diagnostic and treatment purposes of various diseases. In particular, the diseases may involve the mechanism of degradation of extracellular matrix by MMP's during cell proliferation cycle. Suppression of MMP activity seems to arrest tumor growth during cancer progression. MMP oligopeptides were used as vaccines to treat mice having murine melanoma B16FO induced tumor. There was a significant drop in tumor weight and size for the group of mice that were immunized with MMP oligopeptide.

Abstract: Several metal-supported catalyst compositions based on nano-crystalline zinc oxide were synthesized and characterized by X-ray powder diffraction (XRD), Carbon dioxide temperature programmed desorption (CO2 TPD), and nitrogen adsorption at ?196° C. The Pd-supported nano-ZnO mixed with different oxides such as Cr2O3, CrO3, MgO, and ?-Al2O3 showed high catalytic activity in acetone condensation in gas-phase process under hydrogen flow. This reaction involves the base-acid coupling of acetone to form mesityl oxide, followed by its hydrogenation to methyl isobutyl ketone (MIBK). The novel catalyst 1% wt. n-Pd/n-ZnCr2O4 was utilized during gas-phase reaction during production of MIBK. MIBK selectivity was 70-72% at 66-77% acetone conversion at 300-350° C. Diisobutyl ketone (DIBK) was the main by-product, with a total MIBK+DIBK selectivity up to 88%. The prepared catalysts showed stable activity and may be used repeatedly and for a longer period of time.