Abstract: In an injection molding apparatus comprising a clamp plate, a heated manifold and a mold, a system for mounting an actuator to the manifold and the clamp plate, the system comprising: a mount comprised of a thermally conductive material having first and second heat conductive surfaces; the first conductive surface being in heat conductive communication with the actuator, the second conductive surface being in heat conductive communication with the clamp plate; the actuator being mounted in thermal communication with the manifold; the mount being adjustably mounted to the actuator such that the second conductive surface can be adjusted in position toward and away from the actuator.

Abstract: Methods and systems are provided for tracking object instances stored on a plurality of network nodes, which tracking enables a global determination of when an object has no references across the networked nodes and can be safely de-allocated. According to one aspect of the invention, each node has a local object store for tracking and optionally storing objects on the node, and the local object stores collectively share the locally stored instances of the objects across the network. One or more applications, e.g., a file system and/or a storage system, use the local object stores for storing all persistent data of the application as objects.

Abstract: Apparatus for heating a fluid being injected in an injection molding system, the apparatus comprising a mold having a cavity, a fluid flow distribution manifold, a fluid flow channel body, a coiled heater tube comprised of a thermally conductive wall, a heater device disposed within the coiled tube; the coiled tube having an upstream, downstream and intermediate coiled portions, the upstream and downstream coiled portions of the coiled tube being selectively movable away from each other along the coil axis to cause the intermediate coiled portion of the coiled tube to stretch or extend in coil axial length.

Abstract: Film structure characterized in that it includes at least five layers, two outer layers (2) made of a polyolefin on which is each time provided, on the opposite sides, a layer (4) forming a gas barrier and whereby, between both above-mentioned gas barriers (4), is provided a layer (3) made of a foamed synthetic material, whereby the outer layers (2) consist of a mixture of a polyolefin and a binder, which makes it possible to bond this polyolefin with the layer (4) forming the gas barrier.

Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.

Abstract: Disclosed are procedures and methods for diagnosing latent and active cancers in a subject. The described methods include the use of sandwich ELISA assays containing antibodies specific for certain epitopes on the A-protein. This enables the assay to discriminate between the monomelic and homopolymeric forms of A-protein.

Abstract: Oxygen-scavenging polymers and packaging for holding oxygen-sensitive products. A heat treatment process has been found to significantly increase the oxygen-scavenging performance of the polymer. The enhanced scavenging polymer can be effectively incorporated into various packaging, including transparent multilayer containers for beer and juice. In one embodiment, a multilayer package made from the scavenger provides an actual reduction in oxygen content of a contents of the package, over a long period of time (e.g., 24 weeks). The package can be stored unfilled for an extended period (without significant loss of scavenging capability) and will scavenge substantially immediately upon filling with a liquid product. The package may incorporate a relatively low weight percentage of the scavenger, thus providing enhanced scavenging in a cost-effective manner.

Abstract: Apparatus for measuring the temperature of a nozzle having fluid material injected from an injection molding machine through a flow channel in a heated manifold that is coupled to a nozzle that is coupled to the cavity of a mold, the apparatus comprising: a heating device comprising a controllably heatable thermally conductive heating element; the heating element of the heating device being mounted on or around the outer surface of the tube of the nozzle at an end point; a temperature monitor comprising a temperature sensor mounted on or around the nozzle at a selected position along the axis of the bore of the nozzle; and, a thermal insulator disposed along the axis of the nozzle separating the end point of the heating element and the temperature sensor.

Abstract: An injection molding system comprising an actuator, a mounting plate, a mold and a manifold mounted between the mounting plate and the mold, the mounting plate being removably coupled to the mold, a valve pin comprising a pin stem and a pin connector; the actuator housing being mounted on or within the mounting plate for radial movement upon decoupling of the actuator housing from the mounting plate.

Abstract: An apparatus for heating at least one plastic preform for manufacturing containers may include a reflection body, a source of energy for emitting thermal radiation for heating the plastic preform, and a holding member for holding the plastic preform. The holding member may be moved relative to the reflection body, wherein the reflection body has a first surface allocated to the plastic preform and the source of energy is disposed in such a way that the radiation thereof reaches the reflection body. The reflection body may be constructed of at least two components, wherein a first component has the first surface which is at least partially transparent to the radiation emitted by the source of energy and which has a second structured surface on the side facing away from the first surface. At least a portion of the second component is capable of reflecting the radiation, and this second component abuts against the first component at least in sections.

Abstract: A blow molding apparatus for expanding plastic preforms into plastic containers may include a blow piston extending in a longitudinal direction and a blow nozzle extending from the blow piston in the longitudinal direction. The blow nozzle may be configured to apply a gaseous medium to a preform for the expansion thereof. A connection device may be structured and arranged to supply the gaseous medium to the blow molding apparatus via at least two connection lines, and a control block may be arranged between the connection device and the blow piston. The control block may be configured to control the supply of the gaseous medium during the expansion process using at least partially varying pressure levels and may have a plurality of channels for guiding the gaseous medium. The plurality of channels may be separated from each other at least in sections and may be distributed in a circumferential direction of the control block. At least two valves may be on an outer circumference of the control block.

Abstract: Package housing for an elongate object (8), including a base element (2) having a housing wall (6) defining a receptacle (4) for the object (8), wherein the receptacle (4) has a longitudinal axis (L) which runs substantially coaxially to the longitudinal axis of the object (8) in the packed state. The base element (2) comprises a head part (10) and a holding part (12) arranged in the direction of the longitudinal axis (L) next to the head part (10), which holding part is connected to the head part (10) by a weakening zone (30) and including at least one holding portion (34), which is intended to hold the object (8) in the holding part (12). According to the invention, the weakening zone (30) is a predetermined breaking point (32).

Abstract: A medical device delivery system provides for a two-stage withdrawal of a deflated balloon portion of a catheter and the remains of a ruptured sheath. The deflated balloon portion is withdrawn from within an expanded medical device a predetermined distance before the remains of the ruptured sheath begins being removed from between the expanded device and a vessel wall. Initiating removal of the deflated balloon portion before the sheath reduces a total amount of drag that is exerted against a self-expanding medical device that has been deployed in a vessel.

Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.

Abstract: The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1 ”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.

Abstract: Implant (1) with a base body having at least one bone contact surface (K) and at least one soft tissue contact surface (W), characterized in that the soft tissue contact surface (W) and/or a transition area (U) from bone contact surface (K) to soft tissue contact surface (W) have/has at least partially a ceramic coating (2), and in that the bone contact surface (K) has areas not provided with a ceramic coating (2).

Abstract: Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where crysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Abstract: An apparatus for moulding plastic preforms into plastic containers may include at least one blow mould and a plurality of closure elements cooperating with one another in order to transfer the blow mould between an open condition and a closed condition, in which the blow mould forms a cavity, within which the plastic preforms may be expanded into plastic containers. The closure elements include at least one first mould section and one second mould section. The first mould section and the second mould section may be moved between the closed position and the open position in relation to one another. In a closed condition, the first and second mould sections are locked together. The closure elements may further include a bottom section which may be moved relative to the first and second mould sections in order to close the cavity in one direction.